Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Open accessAbstract
Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscillates in a daily manner and is regulated by feeding. We provide biochemical evidence that PARP-1 binds and poly(ADP-ribosyl)ates CLOCK at the beginning of the light phase. The loss of PARP-1 enhances the binding of CLOCK-BMAL1 to DNA and leads to a phase-shift of the interaction of CLOCK-BMAL1 with PER and CRY repressor proteins. As a consequence, CLOCK-BMAL1-dependent gene expression is altered in PARP-1-deficient mice, in particular in response to changes in feeding times. Our results show that Parp-1 knockout mice exhibit impaired food entrainment of peripheral circadian clocks and support a role for PARP-1 in connecting feeding with the mammalian timing system.
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When subjected to daytime feeding, the liver of Parp-1 knockout mice shows a significantly delayed phase inversion of clock gene expression compared with wild type, suggesting PARP-1 activity is implicated in phase entrainment of peripheral oscillators.
“When subjected to daytime feeding the liver of Parp-1 KO mice showed a significantly delayed phase inversion of clock gene expression, when compared with wild type mice, suggesting that PARP-1 activity is indeed implicated in the phase entrainment of peripheral oscillators [48].”
From Circadian control of glucose metabolism (2014) · cites this paper as [48]
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- Authors
- Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Heinrich Heine University Düsseldorf (DE)
- University of Zurich (CH)
- Corresponding author
- Asher, Gad
- Schibler, Ueli
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 6
- Pages
- 943-953
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2126110821
- Cited by
- 340
- References
- 40
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 18 · 2019: 24 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 27 · 2014: 32 · 2013: 32 · 2012: 34
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- PARP1, poly(ADP-ribosyl)ation, circadian clock, feeding-fasting cycle, food entrainment, Clock/BMAL1, liver, PARP-1 knockout mice, NAD+ metabolism, circadian gene expression
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Animals, Biological Clocks, Circadian Rhythm, Feeding Behavior, Liver, Poly(ADP-ribose) Polymerases, Mice, Knockout, Mice, Circadian Rhythm Signaling Peptides and Proteins
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