The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Iron and Copper in Mitochondrial Diseases
Open accessAbstract
Summary Transition metals are frequently used as co-factors for enzymes and oxygen-carrying proteins that take advantage of their propensity to gain and lose single electrons. Metals are particularly important in mitochondria, where they play essential roles in the production of ATP and detoxification of reactive oxygen species. At the same time, transition metals (particularly Fe and Cu) can promote the formation of harmful radicals, necessitating meticulous control of metal concentration and subcellular compartmentalization. We summarize our current understanding of Fe and Cu in mammalian mitochondrial biology, and discuss human diseases associated with aberrations in mitochondrial metal homeostasis.
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Cites
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Self-citationPersister cancer cells: Iron addiction and vulnerability to ferroptosis
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Metadata
- Authors
- Xu, W., Barrientos, T., & Andrews, N. C.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 17
- Issue
- 3
- Pages
- 319-328
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2153287706
- Cited by
- 183
- References
- 15
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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