Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245

Obesity alters gut microbial ecology

Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176

EMSA Eritin Blocks Nuclear Factor-Kappa B in Diabetes Mellitus Mice Model

Sihombing, M. A. L., Sumitro, S. B., & Rifa’i, M. (2015) · The Journal of Experimental Life Sciences · doi:10.21776/ub.jels.2015.005.01.05

The control of lipid-induced inflammation by macrophages

Jaccard, E., & Widmann, C. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000030

MicroRNAs and Long Non-Coding RNAs in Pancreatic Beta Cell Function

WALKER, M. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408134-5.00023-8

The impact of calcium on the interactions between epigallocatechin-3-gallate and B-lactoglobulin and their effects on the metabolic response of mice

Carnovale, V. (2015)

Non-Immune Islet beta cell susceptibility to failure in NODk mice

Hussain, A. H. (2017) · ANU Open Research (Australian National University) · doi:10.25911/5d67b4a4d618c

Population‐based data registries suggest novel insight into malignancy and metabolism

Meydan, C. (2018) · Cancer · doi:10.1002/cncr.31762

Morphogenesis of pancreas under the conditions of glutamate-induced obesity: mechanisms of correction effect of melanin

Belemets, N. I., Falalyeyeva, T. M., Beregova, T. V., Остапченко, Л. І., Kobyliak, N. M., Кuryk, О. G., & Sulaieva, O. (2018) · Bulletin of Taras Shevchenko National University of Kyiv Series “Psychology” · doi:10.17721/1728_2748.2018.76.56-61

Type 2 Diabetes Mellitus in Osteoarthritic Patients: Does Association Between Metabolic Impairments, Joint Destruction, and Pain Exist?

Chetina, E. V., Markova, G. A., & Sharapova, E. P. (2020) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750820020043

Publisher Correction: A BAD portion of glucose can be good for inflamed beta cells

Frezza, C. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0236-3

Oral biosciences: The annual review 2020

Ohshima, H., Mishima, K., & Amizuka, N. (2021) · Journal of Oral Biosciences · doi:10.1016/j.job.2021.02.001

Elucidating the crosstalk between inflammation and DNA damage pathways in the pancreatic beta-cell through the diabetes susceptibility gene, TCF19Preprint

Yang, G. H. Y., Fontaine, D. A., Lodh, S., Blumer, J. T., Roopra, A., & Davis, D. B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.06.438736

Roles of Autophagy in Regulating ER Stress-Mediated Type 2 Diabetes

Islam, M. R. (2021) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2021.13.001853

Review: Obesity Induced Insulin Resistance, Type 2 Diabetes and Emerging Therapeutic Approaches.

(2021) · doi:10.46940/sjdcc.02.1004

Inflammatory Pathways Linked to β Cell Demise in Diabetes

Imai, Y., Morris, M. A., Dobrian, A. D., Taylor, D., & Nadler, J. L. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_30

Urinary interleukin-1ß levels among gynecological patients

Woolery, K. T., Hoffman, M. S., Kraft, J., Nicosia, S. V., Kumar, A., & Kruk, P. A. (2014) · Journal of Ovarian Research · doi:10.1186/preaccept-6004924491339512

Islet Inflammation and Metabolic Homeostasis

Collier, J. J., & Burke, S. J. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-0927-3

Treatment Regimes in Diabetes and Their Impact on Biomarkers

Magalhães, J. P., Hetherington‐Rauth, M., & Sardinha, L. B. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_3-1

Treatment Regimes in Diabetes and Their Impact on Biomarkers

Magalhães, J. P., Hetherington‐Rauth, M., & Sardinha, L. B. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-08014-2_3

UNDERSTANDING THE ROLES OF HETEROGENOUS SWI/SNF COMPLEXES IN REGULATION OF DIFFERENTIAL GENE EXPRESSION

Chakravarty, T. (2022) · doi:10.23860/diss-chakravarty-tomali-2022

The gut microbiota

Scheithauer, T. P. M. (2023) · doi:10.5463/thesis.82

Insulin Secretion and the β-Cell 102 Years After the Discovery of the Hormone

Ortis, F., Rebelato, E., Carpinelli, Â. R., & Abdulkader, F. (2024) · Current Molecular Biology Reports · doi:10.1007/s40610-024-00158-9

Biochemistry and immunology of inflammation-mediated responses in the development of diabetes mellitus

Meur, G., Anindya, R., & Rutter, G. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13195-0.00010-7 · Cited by 2

A bibliometric and visual analysis of neutrophil to lymphocyte ratio from 2004 to 2023Preprint

Jiang, Y., Wu, X., Zhang, T., Li, H., Zhu, Y., & He, L. (2025) · medRxiv · doi:10.1101/2025.08.20.25334135

Les maladies métaboliques sous le prisme de la méta-inflammation

Uzan, B., & Movassat, J. (2025) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2025.11.001

Measuring Adipocytokines in Young Patients With Type 2 Diabetes Presenting to a Tertiary Care Centre in Upper Assam, India

Dutta, A., Saikia, M., Dutta, P. K., Kakati, S., Boruah, A., Bhattacharyya, N., Neog, R., & Nath, R. (2025) · Cureus · doi:10.7759/cureus.98779

THE ROLE OF ATAXIA TELANGIECTASIA MUTATED AND THE CATALYTIC SUBUNIT OF DNA-DEPENDENT PROTEIN KINASE DURING ADIPOGENESIS

Rocourt, C. R. B. (2014) · University Libraries (University of Maryland)

Additional file 1 of The glucose-lowering effect of low-dose diacerein and its responsiveness metabolic markers in uncontrolled diabetes

Jangsiripornpakorn, J., Srisuk, S., Chailurkit, L., Nimitphong, H., Saetung, S., & Ongphiphadhanakul, B. (2022) · Figshare · doi:10.6084/m9.figshare.19311344

In Silico Design of a Multimodal Trimeric Peptide Candidate Predicted to Simultaneously Target Glycemic Control, Autoimmunity, and Pancreatic β-Cell Regeneration in Type 1 DiabetesPreprint

Andrade, L. J. D. O., de Oliveira, G. C. M., & de Oliveira, L. M. (2026) · Research Square · doi:10.21203/rs.3.rs-8951973/v1

Inflammation du tissu adipeux au cours de l'obésité humaine : implication des lymphocytes Th17

Caër, C. (2016) · theses.fr (ABES) · doi:10.70675/65eca5dczaa63z4e9az82dbzb223bfe8ef82 · Cited by 1

Association between Guillain–Barré syndrome and 7 autoimmune diseases: a mendelian randomization study

Zhou, J., Wang, T., Chen, G., Yang, S., Wang, T., & Li, X. (2026) · BMC Neurology · doi:10.1186/s12883-026-04957-8

A transcriptionally distinct population of human adipocytes with end-of-trajectory signature (hEOS) emerges during obesity to drive maladaptive inflammation

Zeng, R., Liang, Z., Cheng, Y., Zhang, H., Li, H., Li, H., Zeng, D., Li, S., & Chen, Y. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108240

Chitosan–Prussian blue nanoparticles for ROS scavenging and diabetes therapy

Chen, Z., Cao, X., Liu, C., Yang, Y., Sun, Y. W., & Li, J. (2026) · Materials Letters · doi:10.1016/j.matlet.2026.140853

Sleeve Gastrectomy Is Associated with Improved Systemic Redox Homeostasis in T2DM Through Ghrelin–GHSR Attenuation, POMC Neuronal Modulation, and CD4 + T Cell Metabolic Reprogramming

Li, X., Zhang, R.-Y., & Liu, W. T. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864261455465

Gut microbiota translocation contributes to early islet apoptosis in streptozotocin-induced diabetes

Wang, Y., Sheng, P., Wang, S., Zhong, X., Cao, H., Li, D., Yan, J., Yang, J. Q., Wang, Y., Peng, J., et al. (2026) · mSystems · doi:10.1128/msystems.00172-26

Current diabetes drugs: Lessons learned and implications for next-generation therapeutics

Liao, J., Cong, Z., Liu, K., Que, H., & Liu, F. (2026) · The Innovation Drug Discovery · doi:10.59717/j.xinn-drugdisc.2026.100008

Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases

Yao, C., Zheng, W., Jin, Y., Sheng, J., Kang, M., Zhong, J., Li, M., Duan, L., & Yuan, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1819389

NOX2-dependent macrophage-β-cell crosstalk exacerbate islet dysfunction in type 2 diabetes

Fang, S., Jiang, M., Liu, D., Gao, D., Gao, L., Jiao, J., Zhao, H., Tang, L., Zhou, Y., & Yuan, H. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168392

Prometheus’s Fire, Part II: The Hydra of Inflammation—Multiorgan Self-Amplifying Inflammatory Loops in Obesity: Molecular Crosstalk Between Adipose Tissue, Liver, Skeletal Muscle, Pancreas and Cardiovascular System

Grudniewska, A., Mrozikiewicz‐Rakowska, B., Wiszniewski, K., Dudek, P., & Kuryłowicz, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209356

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143

The Bidirectional Relationship between Metabolism and Immune Responses

Raval, F. (2013) · Discoveries · doi:10.15190/d.2013.6 · Cited by 27

Immune cells and metabolic dysfunction

Eheim, A. L., Medříková, D., & Herzig, S. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0403-7 · Cited by 27

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551

Immune regulation of islet homeostasis and adaptation

Guo, J., & Fu, W. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa009 · Cited by 29