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Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism
Open accessAbstract
Osteocytes act as mechanosensors to control local bone volume. However, their roles in the homeostasis of remote organs are largely unknown. We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. These effects were reversed when osteocytes were replenished within the bone. In contrast, neither in vivo supply of T cell progenitors and humoral factors via shared circulation with a normal parabiotic partner nor ablation of specific hypothalamic nuclei rescued thymic atrophy and fat loss in OL mice. Furthermore, ablation of the hypothalamus in OL mice led to hepatic steatosis, which was rescued by parabiosis with normal mice. Our results define a role for osteocytes as critical regulators of lymphopoiesis and fat metabolism and suggest that bone acts as a central regulator of multiple organs.
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“Osteocytes also act on the immune system by modifying the microenvironment in primary lymphoid organs and thereby influencing lymphopoiesis [210].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [210]
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Metadata
- Authors
- Sato, M., Asada, N., Kawano, Y., Wakahashi, K., Minagawa, K., Kawano, H., Sada, A., Ikeda, K., Matsui, T., & Katayama, Y.
- Affiliations
- Hokkaido University (JP)
- Kobe University (JP)
- National Center for Geriatrics and Gerontology (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Katayama, Yoshio
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 18
- Issue
- 5
- Pages
- 749-758
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2062462056
- Cited by
- 126
- References
- 33
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 12 · 2018: 8 · 2017: 13 · 2016: 10 · 2015: 12 · 2014: 10
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology (23118517)
- Takeda Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- osteocytes, lymphopenia, lymphoid stroma, bone marrow, thymus, thymic atrophy, fat metabolism, parabiosis, hypothalamus, hepatic steatosis, lymphocyte development, mechanosensing
- MeSH terms
- Animals, Atrophy, Bone Marrow, Lymphoid Tissue, Lymphopenia, Mice, Inbred C57BL, Osteocytes, Stromal Cells, Lymphopoiesis, Lipid Metabolism, Mice, Thymocytes, Cellular Microenvironment
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