Come on BAIBA light my fire
Open accessAbstract
The contracting muscle has been shown to act as an endocrine organ, secreting "myokines" that participate in tissue crosstalk. In this issue of Cell Metabolism, Roberts et al. (2014) identify BAIBA as a contraction-induced myokine that results in browning of white adipose tissue and increases fat oxidation in the liver.
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Circulating levels of BAIBA have an important role against cardiometabolic risks.
“Furthermore, it has been shown that circulating levels of BAIBA have an important role against cardiometabolic risks (Kammoun and Febbraio, 2014).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Kammoun and Febbraio, 2014
Cites
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083 · see citing works
Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works
Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works
β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency
Begriche, K., Massart, J., Abbey‐Toby, A., Igoudjil, A., Lettéron, P., & Fromenty, B. (2008) · Obesity · doi:10.1038/oby.2008.337 · Cited by 99 · see citing works
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226 · see citing works
Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works
“Furthermore, it has been shown that circulating levels of BAIBA have an important role against cardiometabolic risks (Kammoun and Febbraio, 2014).”
BackgroundExercise-induced ’browning’ of adipose tissues
Aldiss, P., Betts, J., Sale, C., Pope, M., Budge, H., & Symonds, M. E. (2018) · Metabolism · doi:10.1016/j.metabol.2017.11.009 · Cited by 175 · see citing works
Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives
Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works
Kwon, J. H., Moon, K. M., & Min, K.-W. (2020) · Healthcare · doi:10.3390/healthcare8040378 · Cited by 116 · see citing works
Acute aerobic exercise leads to increased plasma levels of R- and S-β-aminoisobutyric acid in humans
Stautemas, J., Van Kuilenburg, A. B. P., Stroomer, L., Vaz, F., Blancquaert, L., Lefevere, F. B. D., Everaert, I., & Derave, W. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01240 · Cited by 66 · see citing works
Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works
- Authors
- Kammoun, H. L., & Febbraio, M. A.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Febbraio, Mark A.
- ORCID
- Febbraio, Mark A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 1-2
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1973412402
- Cited by
- 53
- References
- 4
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 11 · 2023: 5 · 2022: 2 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 3
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- myokines, muscle contraction, white adipose tissue browning, fat oxidation, hepatic metabolism, tissue crosstalk, skeletal muscle endocrine function
- MeSH terms
- Aminoisobutyric Acids, Animals, Adipose Tissue, Brown, Cardiovascular Diseases, Humans, Liver, Metabolic Diseases, Adipose Tissue, White
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