Acute aerobic exercise leads to increased plasma levels of R- and S-β-aminoisobutyric acid in humans
Open accessAbstract
Recently, it was suggested that β-aminoisobutyric acid (BAIBA) is a myokine involved in browning of fat. However, there is no evidence for an acute effect of exercise supporting this statement and the metabolic distinct enantiomers of BAIBA were not taken into account. Concerning these enantiomers, there is at this point no consensus about resting concentrations of plasma R- and S-BAIBA. Additionally, a polymorphism of the AGXT2 gene (rs37369) is known to have a high impact on baseline levels of total BAIBA, but the effect on the enantiomers is unknown. Fifteen healthy recreationally active subjects, with different genotypes of rs37369, participated in a randomized crossover trial where they exercised for 1h at 40% of Ppeak or remained at rest. Plasma samples were analyzed for R- and S-BAIBA using dual column HPLC-fluorescence. The plasma concentration of baseline R-BAIBA was 67 times higher compared to S-BAIBA (1734±821 vs 29.3±7.8nM). Exercise induced a 13% and 20% increase in R-BAIBA and S-BAIBA, respectively. The AGXT2 rs37369 genotype strongly affected baseline levels of R-BAIBA, but did not have an impact on baseline S-BAIBA. We demonstrate that BAIBA should not be treated as one molecule, given 1) the markedly uneven distribution of its enantiomers in human plasma favoring R-BAIBA, and 2) their different metabolic source, as evidenced by the AGXT2 polymorphism only affecting R-BAIBA. The proposed function in organ cross talk is supported by the current data and may apply to both enantiomers, but the tissue of origin remains unclear.
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Two studies have reported increased circulating levels of BAIBA following aerobic exercise, e.g., cycling for 1 h at 40% maximal power output or after 20 weeks of 30-50 min cycling sessions at 55-75% VO2 max in healthy young men.
“two studies have reported increased circulating levels of BAIBA following aerobic exercise, e.g., cycling for 1 h at 40% maximal power output [106] or after 20 weeks of 30–50 min cycling sessions at 55–75% VO2 max [104] in healthy young men.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [106]
The Results (Effect of Exercise; page not provided) report increased circulating R-BAIBA after one hour at 40% of maximal power output. But the Subjects section describes 12 men and 3 women, so the characterization of this study as being in healthy young men is not fully accurate. The 20-week intervention is attached to a different citation. (LLM, conf=0.88)
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- Authors
- Stautemas, J., Van Kuilenburg, A. B. P., Stroomer, L., Vaz, F., Blancquaert, L., Lefevere, F. B. D., Everaert, I., & Derave, W.
- Affiliations
- Ghent University (BE)
- Amsterdam University Medical Centers (NL)
- Corresponding author
- Derave, Wim
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2019-09-25
- Volume
- 10
- Pages
- 1240-1240
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC6773837
- OpenAlex
- W2976893143
- Cited by
- 66
- References
- 44
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 7 · 2023: 15 · 2022: 17 · 2021: 9 · 2020: 8 · 2019: 1
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- Griffith Research Online (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- beta-aminoisobutyric acid, enantiomers, acute aerobic exercise, myokines, fat browning, organ crosstalk
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