Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Heart-Lung Transplantation

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

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Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

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Mitochondrial Membrane Potential in Living Cells

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Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

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Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 497

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

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Metabolic control of epigenetics in cancer

Kinnaird, A. S., Zhao, S., Wellen, K. E., & Michelakis, E. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.82 · Cited by 429

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

D’Onofrio, N., Servillo, L., & Balestrieri, M. L. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7178 · Cited by 396

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

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The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

Carrico, C., Meyer, J. G., He, W., Gibson, B. W., & Verdin, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.016 · Cited by 331

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

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DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

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Function of the SIRT 3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

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SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction

Lai, Y.-C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St. Croix, C. M., Garcia-Ocaña, A., Goncharova, E. A., Tofovic, S. P., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.018935 · Cited by 270

Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease

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Sirtuins, Cell Senescence, and Vascular Aging

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Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis

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Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

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Hypoxia-inducible factor signaling in pulmonary hypertension

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The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure

Boucherat, O., Agrawal, V., Lawrie, A., & Bonnet, S. (2022) · Circulation Research · doi:10.1161/circresaha.121.319971 · Cited by 210

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Pillai, V. B., Kanwal, A., Fang, Y. H., Sharp, W. W., Samant, S. A., Arbiser, J. L., & Gupta, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.16133 · Cited by 194

The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis

Sosnowska, B., Mazidi, M., Penson, P. E., Gluba-Brzózka, A., Rysz, J., & Banach, M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.027 · Cited by 188

Sirt3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

Kim, T. S., Jin, Y. B., Kim, Y. S., Kim, S., Kim, J. K., Lee, H.-M., Suh, H.-W., Choe, J. H., Kim, Y. J., Koo, B.-S., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1582743 · Cited by 172

The role of mitochondrial sirtuins in health and disease

Osborne, B., Bentley, N. L., Montgomery, M. K., & Turner, N. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.197 · Cited by 183

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

Culley, M. K., & Chan, S. Y. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120847 · Cited by 178

SIRT3: A New Regulator of Cardiovascular Diseases

Sun, W., Liu, C., Chen, Q., Liu, N., Yan, Y., & Liu, B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7293861 · Cited by 172

Current and future treatments of pulmonary arterial hypertension

Sommer, N., Ghofrani, H. A., Pak, O., Bonnet, S., Provencher, S., Sitbon, O., Rosenkranz, S., Hoeper, M. M., & Kiely, D. G. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15016 · Cited by 165

Cellular Metabolism in Lung Health and Disease

Liu, G., & Summer, R. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114640 · Cited by 157

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 150

Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension

Bonnet, S., Provencher, S., Guignabert, C., Perros, F., Boucherat, O., SCHERMULY, R. T., Hassoun, P. M., Rabinovitch, M., Nicolls, M. R., & Humbert, M. J. C. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201607-1515pp · Cited by 138

BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension

Cuthbertson, I., Morrell, N. W., & Caruso, P. L. (2023) · Circulation Research · doi:10.1161/circresaha.122.321554 · Cited by 129

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

Kim, S.-J., Cheresh, P., Jablonski, R. P., Williams, D. B., & Kamp, D. W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921486 · Cited by 125

Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension

Lewis, G. D., Ngo, D., Hemnes, A. R., Farrell, L. A., Domos, C., Pappagianopoulos, P. P., Dhakal, B. P., Souza, A., Shi, X. D., Pugh, M. E., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.072 · Cited by 123

Diagnosis, Treatment, and Clinical Management of Pulmonary Arterial Hypertension in the Contemporary Era

Maron, B. A., & Galiè, N. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.4471 · Cited by 127

Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease

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Mechanisms and treatment of pulmonary arterial hypertension

Ghofrani, H. A., Gomberg‐Maitland, M., Zhao, L., & Grimminger, F. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01064-4 · Cited by 134

Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy

Chelladurai, P., Boucherat, O., Stenmark, K. R., Kracht, M., Seeger, W., Bauer, U., Bonnet, S., & Pullamsetti, S. S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14932 · Cited by 117

Mitochondria Related Cell Death Modalities and Disease

Tian, C., Liu, Y., Li, Z., Zhu, P., & Zhao, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.832356 · Cited by 113

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

D’Alessandro, A., Kasmi, K. C. E., Plecitá‐Hlavatá, L., Ježek, P., Li, M., Zhang, H., Gupte, S. A., & Stenmark, K. R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7217 · Cited by 111

Sirtuins in vascular diseases: Emerging roles and therapeutic potential

D’Onofrio, N., Vitiello, M., Casale, R., Servillo, L., Giovane, A., & Balestrieri, M. L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.001 · Cited by 106

DNA Damage and Pulmonary Hypertension

Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 111

Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice

Chan, S. Y., & Rubin, L. J. (2017) · European Respiratory Review · doi:10.1183/16000617.0094-2017 · Cited by 97

Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension

Kikuchi, N., Satoh, K., Kurosawa, R., Yaoita, N., Al-Mamun, M. E., Siddique, M. A. H., Omura, J., Satoh, T., Nogi, M., Sunamura, S., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.033113 · Cited by 95

The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis

Murtha, L. A., Morten, M., Schuliga, M. J., Mabotuwana, N. S., Hardy, S. A., Waters, D. W., Burgess, J. K., Ngo, D. T. M., Sverdlov, A. L., Knight, D. A., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0601 · Cited by 98

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

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Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation

Mistriotis, P., & Andreadis, S. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.006 · Cited by 89

Mitochondrial Sirtuins in cardiometabolic diseases

Tang, X., Chen, X., Chen, H., & Liu, D. (2017) · Clinical Science · doi:10.1042/cs20160685 · Cited by 87

Suppression of Endothelial-to-Mesenchymal Transition by SIRT (Sirtuin) 3 Alleviated the Development of Hypertensive Renal Injury

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A systematic review of genetic mutations in pulmonary arterial hypertension

García‐Rivas, G., Carlos Jerjes-Sánchez, D., Rodríguez, D., Garcia‐Pelaez, J., & Treviño, V. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0440-5 · Cited by 86

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice

Zhang, Y., Wang, X., Li, X.-K., Lv, S., Wang, H., Liu, Y., Zhou, J., Gong, H., Chen, X.-F., Ren, S., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad381 · Cited by 84

Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again

Prins, K. W., Thenappan, T., Weir, Ε. K., Kalra, R., PRITZKER, M. R., & Archer, S. L. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.011343 · Cited by 80

Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling

Balistrieri, A., Makino, A., & Yuan, J. X. ‐. (2022) · Physiological Reviews · doi:10.1152/physrev.00030.2021 · Cited by 77

Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension

Malenfant, S., Potus, F., Fournier, F., Breuils‐Bonnet, S., Pflieger, A., Bourassa, S., Tremblay, È., Nehmé, B., Droit, A., Bonnet, S., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1244-0 · Cited by 74

Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Jiang, J., Liang, S., Zhang, J., Du, Z., Xu, Q., Duan, J., & Sun, Z. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12686 · Cited by 71

Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss

Xia, L., Sun, C., Zhu, H., Zhai, M., Zhang, L., Jiang, L., Hou, P., Li, J., Li, K., Liu, Z., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12661 · Cited by 72

Using mitochondrial sirtuins as drug targets: disease implications and available compounds

Gertz, M., & Steegborn, C. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2180-7 · Cited by 73

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

Chen, Y., Qing, W., Sun, M., Lv, L., Guo, D., & Jiang, Y. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1067806 · Cited by 71

Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3

Xu, H., Hertzel, A. V., Steen, K. A., & Bernlohr, D. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1301 · Cited by 71

Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension

Vilarinho, S., Sarı, S., Yılmaz, G., Stiegler, A. L., Boggon, T. J., Jain, D., Akyol, G., Dalgıç, B., Günel, M., & Lifton, R. P. (2016) · Hepatology · doi:10.1002/hep.28499 · Cited by 69

Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation

Zurlo, G., Piquereau, J., Moulin, M., Silva, J. P. D., Gressette, M., Ranchoux, B., Garnier, A., Ventura‐Clapier, R., Fadel, É., Humbert, M. J. C., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001676 · Cited by 69

Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics

Ding, Y.-N., Wang, H.-Y., Chen, X.-F., Tang, X., & Chen, H. (2025) · Circulation Research · doi:10.1161/circresaha.124.325440 · Cited by 67

Animal models of scleroderma: recent progress

Marangoni, R. G., Varga, J., & Tourtellotte, W. G. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000331 · Cited by 61

An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease

Suratt, B. T., Ubags, N. D. J., Rastogi, D., Tantisira, K. G., Marsland, B. J., Petrache, I., Allen, J. B., Bates, J. H. T., Holguín, F., McCormack, M. C., et al. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201703-263ws · Cited by 58

Sirtuin 3: Emerging therapeutic target for cardiovascular diseases

Cao, M., Zhao, Q., Sun, X., Qian, H., Lyu, S., Chen, R., Xia, H., & Yuan, W. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.005 · Cited by 59

The emerging role of epigenetics in pulmonary hypertension

Gamen, E., Seeger, W., & Pullamsetti, S. S. (2016) · European Respiratory Journal · doi:10.1183/13993003.01714-2015 · Cited by 57

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

Harvey, L. D., & Chan, S. Y. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6040043 · Cited by 59

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension

Kurosawa, R., Satoh, K., Kikuchi, N., Kikuchi, H., Saigusa, D., Al-Mamun, M. E., Siddique, M. A. H., Omura, J., Satoh, T., Sunamura, S., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315229 · Cited by 56

Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen‐Sensing, Metabolism, and Dynamics

Dasgupta, A., Wu, D., Tian, L., Xiong, P. Y., Dunham‐Snary, K. J., Chen, K., Alizadeh, E., Motamed, M., Potus, F., Hindmarch, C. C. T., et al. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190027 · Cited by 64

Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension

Nozik‐Grayck, E., Woods, C., Stearman, R. S., Venkataraman, S., Ferguson, B. S., Swain, K. E., Bowler, R. P., Geraci, M. W., Ihida‐Stansbury, K., Stenmark, K. R., et al. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00263.2015 · Cited by 54

Animals in Respiratory Research

Fröhlich, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052903 · Cited by 54

Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension

Harbaum, L., Baaske, K. M., Simon, M., Oqueka, T., Sinning, C., Glatzel, A., Lüneburg, N., Sydow, K., Bokemeyer, C., & Klose, H. F. E. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0407-5 · Cited by 53

SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications

Lü, Y., Wang, Y., Wang, X., Chen, H., Cai, Z., & Xiang, M. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.236 · Cited by 52

Sirtuins Expression and Their Role in Retinal Diseases

Balaiya, S., Abu‐Amero, K. K., Kondkar, A. A., & Chalam, K. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3187594 · Cited by 52

Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy

Gano, L. B., Liang, L.-P., Ryan, K., Michel, C. R., Gomez, J., Vassilopoulos, A., Reisdorph, N. A., Fritz, K. S., & Patel, M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.063 · Cited by 54

SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity

Yang, L., Zhang, J., Xing, W., Zhang, X., Xu, J., Zhang, H., Chen, L., Ning, X., Ji, G., Li, J., et al. (2016) · Scientific Reports · doi:10.1038/srep23366 · Cited by 50

Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress

Feng, H., Wang, J.-Y., Yu, B., Cong, X., Zhang, W., Li, L., Liu, L., Zhou, Y., Zhang, C., Gu, P.-L., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7620 · Cited by 49

Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions

Afzaal, A., Rehman, K., Kamal, S., & Akash, M. S. H. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23047 · Cited by 49

SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension

Yao, Y., Li, H., Da, X., He, Z., Tang, B., Li, Y., Hu, C., Xu, C., Chen, Q., & Wang, Q. K. (2019) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2019.01.007 · Cited by 49

Modulation of mitochondria and NADPH oxidase function by the nitrate-nitrite-NO pathway in metabolic disease with focus on type 2 diabetes

Schiffer, T. A., Lundberg, J. O., Weitzberg, E., & Carlström, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165811 · Cited by 49

Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism

Agrawal, V., Lahm, T., Hansmann, G., & Hemnes, A. R. (2020) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-20-404 · Cited by 50

Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha)

Luo, D., Li, W., Xie, C., Yin, L., Su, X., Chen, J., & Huang, H. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18778 · Cited by 46

SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells

Li, P., Liu, Y., Burns, N., Zhao, K., & Song, R. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2932 · Cited by 46

SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway.

Guo, X., Yan, F., Li, J., Zhang, C., & Bu, P. (2017) · PubMed Central · Cited by 45

Epigenetic Modulation in the Initiation and Progression of Pulmonary Hypertension

Cheng, X., Wang, Y., & Du, L. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13458 · Cited by 43

The Warburg effect: A new story in pulmonary arterial hypertension

Peng, H., Xiao, Y., Deng, X., Luo, J.-F., Hong, C., & Qin, X. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.07.017 · Cited by 41

SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction

He, P., Li, Z., Yue, Z., Gao, H., Feng, G., Wang, P., Huang, Y., Luo, W., Hong, H., Liang, L., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.027 · Cited by 41

Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence

van der Feen, D. E., Berger, R. M. F., & Bartelds, B. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0329tr · Cited by 38

Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells

Qin, H.-L., Bao, J., Tang, J., Xu, D., & Shen, L. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00074.2022 · Cited by 39

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease

Shetty, A. K., Upadhya, R., Madhu, L. N., & Kodali, M. (2019) · Aging and Disease · doi:10.14336/ad.2019.0330 · Cited by 38

Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension

Niihori, M., Eccles, C. A., Kurdyukov, S., Zemskova, M., Varghese, M. V., Степанова, А., Galkin, A. S., Rafikov, R., & Rafikova, O. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0065oc · Cited by 39

Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension

Wang, Y., Yan, L., Zhang, Z., Prado, E., Fu, L., Xu, X., & Du, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00241 · Cited by 38

Recent advances in mouse models for systemic sclerosis

Yue, X., Yu, X., Petersen, F., & Riemekasten, G. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.06.013 · Cited by 38

Metabolic syndrome, neurohumoral modulation, and pulmonary arterial hypertension

Maron, B. A., Leopold, J. A., & Hemnes, A. R. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14968 · Cited by 38

Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events

Anwar, M. A., Saleh, A. I., Olabi, R. A., Shehabi, T. S. A., & Eid, A. H. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.02.002 · Cited by 38

SIRT6 in Vascular Diseases, from Bench to Bedside

Ren, S., Chen, X., Gong, H., Wang, H., Wu, C. F., Li, P., Chen, X., Qu, J.-H., & Tang, X. (2022) · Aging and Disease · doi:10.14336/ad.2021.1204 · Cited by 35

Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension

Lee, M. H., Sanders, L., Kumar, R., Hernández-Saavedra, D., Yun, X., Ford, J. A., Perez, M. J., Mickael, C. S., Gandjeva, A., Koyanagi, D. E., et al. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00039.2022 · Cited by 33

Emerging Therapies and Future Directions in Pulmonary Arterial Hypertension

Gurtu, V., & Michelakis, E. D. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.01.028 · Cited by 33

Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension

Tseng, V., Sutliff, R. L., & Hart, C. M. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7695 · Cited by 34

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders

Gomes, P., Viana, S., Nunes, S., Rolo, A. P., Palmeira, C. M., & Reis, F. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100983 · Cited by 34

New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases

Riou, M., Alfatni, A., Charles, A., Andrès, E., Pistea, C., Charloux, A., & Gény, B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051253 · Cited by 34

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

Winnik, S. H., Gaul, D. S., Siciliani, G., Lohmann, C., Pasterk, L., Calatayud, N., Weber, J., Eriksson, U., Auwerx, J. H., van Tits, L. J., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0552-7 · Cited by 33

Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension

Goncharov, D. A., Goncharova, E. A., Tofovic, S. P., HU, J. L., Baust, J., Pena, A. Z., Ray, A., Rode, A., Vanderpool, R. R., Mora, A. L., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0022le · Cited by 34

Abstract 18830: Mitochondrial Suppression Due to Loss of Sirt3 Deacetylase Activity Causes Pulmonary Arterial Hypertension

Paulin, R., Dromparis, P., Sutendra, G., Provencher, S., Bonnet, S., & Michelakis, E. D. (2013) · Circulation · doi:10.1161/circ.128.suppl_22.a18830

Abstract 17011: Loss-of-function SIRT3 Single Nucleotide Polymorphisms in Patients With Pulmonary Arterial Hypertension (PAH): Insights into the Metabolic Basis of PAH

Gurtu, V., Paulin, R., Webster, L., PATERSON, I. S., Provencher, S., Bonnet, S., & Michelakis, E. D. (2013) · Circulation

Abstract 19386: The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap Syndrome” and a Common Therapy?

Paulin, R., Zang, H., Boukouris, A. E., Gurtu, V., Haromy, A., & Michelakis, E. D. (2015) · Circulation · doi:10.1161/circ.132.suppl_3.19386

Abstract 13575: Lack of Both Mitochondrial Proteins Sirt3 and Ucp2 in Mice Recapitulates Many Critical Features of Human Pulmonary Arterial Hypertension (PAH), Including Inflammatory Plexogenic Lesions, Supporting the Metabolic Theory of PAH

Zhang, Y., Zervopoulos, S. D., Boukouris, A. E., Saleme, B., Liu, Y., Haromy, A., Webster, L., Dakhili, S. A. T., Ussher, J. R., Sutendra, G., et al. (2020) · Circulation · doi:10.1161/circ.142.suppl_3.13575

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Li, M., Plecitá‐Hlavatá, L., Dobrinskikh, E., McKeon, B. A., Gandjeva, A., Riddle, S. R., Laux, A., Prasad, R. R., Kumar, S., Tuder, R. M., et al. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0360oc · Cited by 35