Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

Winnik, Stephan; Auwerx, Johan; Sinclair, David A.; Matter, Christian M.

doi:10.1093/eurheartj/ehv290

Cited by 422

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

Winnik, Stephan, Auwerx, Johan, Sinclair, David A., Matter, Christian M.·2015·European Heart Journal

DOI 10.1093/eurheartj/ehv290PMC PMC4685177

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehv290

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Intracellular activation of SIRT1 protects against atherosclerosis.
“Mounting evidence has demonstrated that intracellular activation of SIRT1 protects against atherosclerosis.30–33”
From Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation (2025) · cites this paper as [33]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Self-citation
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Self-citation
ESC/EAS Guidelines for the management of dyslipidaemias
Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Sirtuins as regulators of metabolism and healthspan
Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008
Self-citation
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., et al. (2007) · Nature · doi:10.1038/nature06261 · Cited by 1,707
Self-citation
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687
Oxidative Stress and Vascular Disease
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · cited 1×
“DNA damage, and progressive respiratory chain dysfunction activate several signalling pathways underlying endothelial dysfunction and vascular inflammation in atherogenesis.(33) Sirt3-dependent transcriptional induction of SOD2 and catalase was shown to prevent”
Background
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585
Self-citation
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 1×
“First evidence of a connection between Sirt1 and endothelial cells was that Sirt1 activates endothelial nitric oxide synthase (eNOS).(11) Later on, studies”
Background
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R. S., Griffith, D., Griffor, M., Loulakis, P., Pabst, B., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088682 · Cited by 915
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.013 · Cited by 899
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
Hirschey, M. D., Shimazu, T., Jing, E., Grueter, C. A., Collins, A. M., Aouizerat, B., Stančáková, A., Goetzman, E., Lam, M. M., Schwer, B., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.019 · Cited by 787 · cited 2×
“In this context, Sirt3 deficiency accelerated the development of the metabolic syndrome in mice, a cluster of risk factors for cardiovascular diseases.(37,46)”
Background
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719
Self-citation
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
McCord, R. A., Michishita, E., Hong, T., Berber, E., Boxer, L. D., Kusumoto, R., Guan, S., Shi, X., Gozani, O., Burlingame, A. L., et al. (2009) · Aging · doi:10.18632/aging.100011 · Cited by 313
SIRT6 protects against pathological damage caused by diet‐induced obesity
Kanfi, Y., Peshti, V., Gil, R., Naiman, S., Nahum, L., Levin, E., Kronfeld‐Schor, N., & Cohen, H. Y. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00544.x · Cited by 311
Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion
Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098972 · Cited by 305
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans
Paulin, R., Dromparis, P., Sutendra, G., Gurtu, V., Zervopoulos, S., Bowers, L., Haromy, A., Webster, L., Provencher, S., Bonnet, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.011 · Cited by 214
Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment
Balestrieri, M. L., Rizzo, M. R., Barbieri, M., Paolisso, P., D’Onofrio, N., Giovane, A., Siniscalchi, M., Minicucci, F., Sardu, C., D’Andrea, D., et al. (2015) · Diabetes · doi:10.2337/db14-1149 · Cited by 196
The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
Miranda, M. X., van Tits, L. J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A. P., Suri, V., Ellis, J. L., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu095 · Cited by 153
Self-citation

Flagged first, then by citations

Research works printed but not linked: 72

10.1056/NEJMra1100831 · DOI · Paper page
10.1152/ajpendo.00054.2012 · DOI
Roth GS Ingram DK Lane MA . Caloric restriction in primates and relevance to humans. Ann N Y Acad Sci 2001;928:305–315. · DOI
10.1126/science.1173635 · DOI · Paper page
10.1038/nm1102-1211 · DOI
10.1093/cvr/cvn224 · DOI · Paper page
10.1093/eurheartj/ehq107 · DOI · Paper page
Stein S Schafer N Breitenstein A Besler C Winnik S Lohmann C Heinrich K Brokopp CE Handschin C Landmesser U Tanner FC Luscher TF Matter CM . SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging (Albany NY) 2010;2:353–360. · DOI
10.1161/ATVBAHA.114.303415 · DOI · Paper page
10.1161/CIRCULATIONAHA.112.124404 · DOI · Paper page
10.2174/157016112798829841 · DOI
10.1093/cvr/cvq339 · DOI
10.1161/CIRCULATIONAHA.112.097295 · DOI
10.1016/j.cmet.2011.10.007 · DOI · Paper page
10.1038/nature09917 · DOI
10.1101/gad.435107 · DOI · Paper page
10.1161/CIRCULATIONAHA.110.958033 · DOI
10.1161/CIRCULATIONAHA.112.001212 · DOI
10.1128/MCB.01636-07 · DOI · Paper page
10.1172/JCI69413 · DOI
10.1016/j.cell.2010.10.002 · DOI · Paper page
10.1016/j.freeradbiomed.2013.05.002 · DOI
10.1074/jbc.M112.355206 · DOI
10.1067/mhj.2000.103934 · DOI
10.1126/science.283.5407.1482 · DOI · Paper page
10.1007/s00395-013-0399-0 · DOI
10.1172/JCI39162 · DOI
Hafner AV Dai J Gomes AP Xiao CY Palmeira CM Rosenzweig A Sinclair DA . Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) 2010;2:914–923. · DOI
10.1128/MCB.00426-08 · DOI
10.1073/pnas.0803790105 · DOI · Paper page
10.1083/jcb.201404118 · DOI · Paper page
10.1016/j.tibs.2013.12.002 · DOI
10.1016/j.febslet.2012.02.014 · DOI
10.1016/j.yexcr.2014.07.013 · DOI
10.1038/nm.2961 · DOI
10.1016/j.cell.2009.12.041 · DOI · Paper page
10.1074/jbc.M113.481473 · DOI
10.1016/j.cell.2008.10.052 · DOI · Paper page
10.1371/journal.pgen.1002153 · DOI
10.1073/pnas.1200583109 · DOI · Paper page
10.1126/science.1202723 · DOI · Paper page
10.1016/j.cell.2005.11.044 · DOI · Paper page
10.1016/j.mito.2011.07.003 · DOI
10.1101/gad.1588507 · DOI · Paper page
10.1039/c3mb00001j · DOI
10.1016/j.jacc.2009.09.009 · DOI · Paper page
Lappas M . Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm 2012;2012:597514. · DOI
10.1016/j.cmet.2014.08.001 · DOI
10.1161/CIRCRESAHA.107.164558 · DOI
10.1016/j.cmet.2014.03.006 · DOI
10.2337/db09-1191 · DOI · Paper page
10.1371/journal.pone.0053106 · DOI
10.1016/j.cmet.2013.02.001 · DOI
10.1016/j.exger.2005.09.008 · DOI
10.1371/journal.pone.0027157 · DOI
10.1016/j.cmet.2011.10.002 · DOI · Paper page
10.1038/nature05354 · DOI · Paper page
10.1126/science.1231097 · DOI · Paper page
10.1111/acel.12220 · DOI
10.1161/JAHA.113.000042 · DOI · Paper page
10.1016/j.cell.2013.11.037 · DOI · Paper page
10.1016/j.cell.2013.06.016 · DOI · Paper page
10.1083/jcb.201207019 · DOI
10.1016/j.mad.2009.11.002 · DOI · Paper page
10.1016/j.cmet.2011.03.004 · DOI · Paper page
10.1016/j.cmet.2012.04.022 · DOI · Paper page
10.1093/cvr/cvm110 · DOI
10.1089/ars.2011.4487 · DOI
10.1161/CIRCGENETICS.111.961144 · DOI · Paper page
10.1093/eurheartj/ehv236 · DOI
10.1373/clinchem.2007.099366 · DOI
10.1038/nrd3738 · DOI

Sorted by citations

NAD+ homeostasis in health and disease
Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627
Self-citation
The Aging Cardiovascular System
Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618
Repairing mitochondrial dysfunction in disease
Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104908 · Cited by 337
Impact of CCR5, Integrase and Protease Inhibitors on Human Endothelial Cell Function, Stress, Inflammation and Senescence
Afonso, P., Auclair, M., Caron-Debarle, M., & Capeau, J. (2017) · Antiviral Therapy · doi:10.3851/imp3160 · Cited by 28
High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restriction
Maldonado, M., Chen, J., Duan, H., Huang, T., Jiang, G., & Zhong, Y. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.02.001 · Cited by 11
Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation
Velagapudi, S., Miranda, M. X., Adla, P., Kraler, S., Mohammed, S. A., Baki, S., Robert, J., Rohrer, L., Lee, H., Jang, H.-D., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf087 · Cited by 4

Authors: Winnik, S., Auwerx, J., Sinclair, D. A., & Matter, C. M.
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2015-06-25
Volume: 36
Issue: 48
Pages: 3404-3412
ISSN: 0195-668X
1522-9645
DOI: 10.1093/eurheartj/ehv290
PMC: PMC4685177
Cited by: 422
References: 24
Language: en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks