Genetic Architecture of Insulin Resistance in the Mouse

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633

Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165

Metabolite profiles and the risk of developing diabetes

Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775

Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk

Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641

Multi-omics approaches to disease

Hasin, Y., Seldin, M., & Lusis, A. (2017) · Genome Biology · doi:10.1186/s13059-017-1215-1 · Cited by 2,953

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939

Animal models of obesity and diabetes mellitus

Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 893

Sex differences and hormonal effects on gut microbiota composition in mice

Org, E., Mehrabian, M., Parks, B. W., Shipkova, P., Liu, X., Drake, T. A., & Lusis, A. J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1203502 · Cited by 796

Role of Estrogens in the Regulation of Liver Lipid Metabolism

Palmisano, B. T., Zhu, L., & Stafford, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_12 · Cited by 577

Sex differences in lipid and lipoprotein metabolism

Palmisano, B. T., Zhu, L., Eckel, R. H., & Stafford, J. M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.008 · Cited by 551

Genetic and environmental control of host-gut microbiota interactions

Org, E., Parks, B. W., Joo, J. W. J., Emert, B., Schwartzman, W., Kang, E. Y., Mehrabian, M., Pan, C., Knight, R., Gunsalus, R., et al. (2015) · Genome Research · doi:10.1101/gr.194118.115 · Cited by 381

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461

Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases

Arnold, A. P., Cassis, L. A., Eghbali, M., Reue, K., & Sandberg, K. L. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307301 · Cited by 339

The role of sex in the genomics of human complex traits

Khramtsova, E. A., Davis, L. K., & Stranger, B. E. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0083-1 · Cited by 303

Genetic Basis for Sex Differences in Obesity and Lipid Metabolism

Link, J. C., & Reue, K. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064827 · Cited by 306

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Ribas, V., Drew, B. G., Zhou, Z., Phun, J., Kalajian, N. Y., Soleymani, T., Daraei, P., Widjaja, K., Wanagat, J., de Aguiar Vallim, T. Q., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3815 · Cited by 259

Diet, genetics, and the gut microbiome drive dynamic changes in plasma metabolites

Fujisaka, S., Avila-Pacheco, J., Soto, M., Kostic, A., Dreyfuss, J. M., Pan, H., Ussar, S., Altindis, E., Li, N., Bry, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.060 · Cited by 231

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

Rajbhandari, P., Thomas, B. J., Feng, A., Hong, C., Wang, J., Vergnes, L., Sallam, T., Wang, B., Sandhu, J., Seldin, M. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.019 · Cited by 190

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

Civelek, M., Wu, Y., Pan, C., Raulerson, C. K., Ko, A., He, A., Tilford, C. A., Saleem, N. K., Stančáková, A., Scott, L. J., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.01.027 · Cited by 176

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

Handzlik, M. K., Gengatharan, J. M., Frizzi, K. E., McGregor, G. H., Martino, C., Rahman, G., Gonzalez, A., Moreno, A. M., Green, C. R., Guernsey, L. S., et al. (2023) · Nature · doi:10.1038/s41586-022-05637-6 · Cited by 190

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066944 · Cited by 158

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171

Sex differences in metabolism and cardiometabolic disorders

Krishnan, K. C., Mehrabian, M., & Lusis, A. J. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000536 · Cited by 153

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

Bennett, B. J., Davis, R. C., Civelek, M., Orozco, L. D., Wu, J., Qi, H., Pan, C., Packard, R. R. S., Eskin, E., Yan, M., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005711 · Cited by 138

An integrative systems genetic analysis of mammalian lipid metabolism

Parker, B. L., Calkin, A. C., Seldin, M. M., Keating, M. F., Tarling, E. J., Yang, P., Moody, S. C., Liu, Y., Zerenturk, E. J., Needham, E. J., et al. (2019) · Nature · doi:10.1038/s41586-019-0984-y · Cited by 127

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Greco, C. M., Koronowski, K. B., Smith, J. G., Shi, J., Kunderfranco, P., Carriero, R., Chen, S., Samad, M., Welz, P.-S., Zinna, V. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi7828 · Cited by 128

Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity

Valentine, W. J., Yanagida, K., Kawana, H., Kono, N., Noda, N. N., Aoki, J., & Shindou, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101470 · Cited by 127

Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

Buscher, K., Ehinger, E., Gupta, P. P., Pramod, A. B., Wolf, D., Tweet, G., Pan, C., Mills, C. D., Lusis, A. J., & Ley, K. F. (2017) · Nature Communications · doi:10.1038/ncomms16041 · Cited by 123

X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity

Link, J. C., Wiese, C. B., Chen, X., Avetisyan, R., Ronquillo, E., Ma, F., Guo, X., Yao, J., Allison, M., Chen, Y.-D. I., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140223 · Cited by 121

Sex differences in heart mitochondria regulate diastolic dysfunction

Cao, Y., Vergnes, L., Wang, Y.-C., Pan, C., Krishnan, K. C., Moore, T. M., Rosa‐Garrido, M., Kimball, T. H., Zhou, Z., Charugundla, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31544-5 · Cited by 113

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

Norheim, F., Hasin-Brumshtein, Y., Vergnes, L., Krishnan, K. C., Pan, C., Seldin, M. M., Hui, S. T. Y., Mehrabian, M., Zhou, Z., Gupta, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.013 · Cited by 110

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Zhou, Z., Moore, T. M., Drew, B. G., Ribas, V., Wanagat, J., Civelek, M., Segawa, M., Wolf, D. M., Norheim, F., Seldin, M. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax8096 · Cited by 109

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Morrison, M. C., & Kleemann, R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00308 · Cited by 105

The genetic architecture of NAFLD among inbred strains of mice

Hui, S. T. Y., Parks, B. W., Org, E., Norheim, F., Che, N., Pan, C., Castellani, L. W., Charugundla, S., Dirks, D. L., Psychogios, N., et al. (2015) · eLife · doi:10.7554/elife.05607 · Cited by 103

Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes

Kuryłowicz, A., & Koźniewski, K. (2020) · Molecules · doi:10.3390/molecules25092224 · Cited by 104

Resveratrol ameliorates metabolic disorders and insulin resistance in high-fat diet-fed mice

Gong, L., Guo, S., & Zou, Z. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117212 · Cited by 96

Diet‐induced rodent models of obesity‐related metabolic disorders—A guide to a translational perspective

Preguiça, I., Alves, A., Nunes, S., Fernandes, R., Gomes, P., Viana, S., & Reis, F. (2020) · Obesity Reviews · doi:10.1111/obr.13081 · Cited by 123

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

Geoghegan, G., Simcox, J., Seldin, M. M., Parnell, T. J., Stubben, C., Just, S. F., Begaye, L. J., Lusis, A. J., & Villanueva, C. J. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.03.003 · Cited by 90

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.015 · Cited by 84

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Acín-Pérez, R., Iborra, S., Martí-Mateos, Y., Cook, E. C. L., Conde-Garrosa, R., Petcherski, A., Muñoz, M. D. M., Martínez de Mena, R., Krishnan, K. C., Jiménez, C., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00273-8 · Cited by 83

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Kurt, Z., Barrere‐Cain, R., LaGuardia, J. S., Mehrabian, M., Pan, C., Hui, S. T. Y., Norheim, F., Zhou, Z., Hasin-Brumshtein, Y., Lusis, A. J., et al. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0205-7 · Cited by 84

Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice

Yong, J., Parekh, V. S., Reilly, S. M., Nayak, J., Chen, Z., Lebeaupin, C., Jang, I., Zhang, J., Prakash, T. P., Sun, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba9796 · Cited by 77

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

Shu, L., Chan, K. H. K., Zhang, G., Huan, T., Kurt, Z., Zhao, Y., Codoni, V., Trégouët, D., Yang, J. J., Wilson, J. G., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007040 · Cited by 81

Multitissue Multiomics Systems Biology to Dissect Complex Diseases

Yang, X. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.04.006 · Cited by 78

Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

Ferrara, P. J., Rong, X., Maschek, J. A., Verkerke, A. R. P., Siripoksup, P., Song, H., Green, T. D., Krishnan, K. C., Johnson, J. M., TURK, J. W., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci135963 · Cited by 78

Sex Differences in Macrophage Responses to Obesity-Mediated Changes Determine Migratory and Inflammatory Traits

Chen, K.-H. E., Lainez, N. M., & Coss, D. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000490 · Cited by 72

Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits

Traglia, M., Bseiso, D. N. F., Gusev, A., Adviento, B., Park, D., Mefford, J., Zaitlen, N., & Weiss, L. A. (2016) · Genetics · doi:10.1534/genetics.116.193623 · Cited by 72

The virtuous cycle of human genetics and mouse models in drug discovery

Nadeau, J. H., & Auwerx, J. H. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0009-9 · Cited by 78

Genetic and hormonal control of hepatic steatosis in female and male mice

Norheim, F., Hui, S. T. Y., Külahçıoğlu, E., Mehrabian, M., Cantor, R. M., Pan, C., Parks, B. W., & Lusis, A. J. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m071522 · Cited by 74

Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus

Lutz, T. A. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00818-3 · Cited by 68

Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance

Nelson, M. E., Madsen, S., Cooke, K. C., Fritzen, A. M., Thorius, I. H., Masson, S. W. C., Carroll, L., Weiss, F. C., Seldin, M. M., Potter, M., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.013 · Cited by 61

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner

Krishnan, K. C., Floyd, R. R., Sabir, S., Jayasekera, D. W., León‐Mimila, P., Jones, A. E., Cortez, A. A., Shravah, V., Péterfy, M., Stiles, L., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.09.004 · Cited by 62

Adipocyte OGT governs diet-induced hyperphagia and obesity

Li, M., Vera, N. B., Yang, Y., Zhang, B., Ni, W., Ziso-Qejvanaj, E., Ding, S., Zhang, K., Yin, R., Wang, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07461-x · Cited by 64

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

Krishnan, K. C., Vergnes, L., Acín‐Pérez, R., Stiles, L., Shum, M., Ma, L., Mouisel, É., Pan, C., Moore, T. M., Péterfy, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00481-w · Cited by 61

Sex-specific metabolic functions of adipose Lipocalin-2

Krishnan, K. C., Sabir, S., Shum, M., Meng, Y., Acín‐Pérez, R., Lang, J. M., Floyd, R. R., Vergnes, L., Seldin, M. M., Fuqua, B. K., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.009 · Cited by 59

Systems genetics applications in metabolism research

Seldin, M. M., Yang, X., & Lusis, A. J. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0132-x · Cited by 55

Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models

Chen, Y., Kim, M., Paye, S. M., & Benayoun, B. A. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105852 · Cited by 59

Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet‐Induced Insulin Resistance in Mice

Yang, J., Guo, Y., Henning, S. M., Chan, B. C., Long, J., Zhong, J., Acín‐Pérez, R., Petcherski, A., Shirihai, O. S., Heber, D., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000091 · Cited by 54

Effect of GPR84 deletion on obesity and diabetes development in mice fed long chain or medium chain fatty acid rich diets

Toit, E. D., Browne, L., Irving‐Rodgers, H. F., Massa, H. M., Fozzard, N., Jennings, M. P., & Peak, I. R. A. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1456-5 · Cited by 50

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

Mann, S. N., Hadad, N., Holte, M. N., Rothman, A. R., Sathiaseelan, R., Mondal, S. A., Agbaga, M., Unnikrishnan, A., Subramaniam, M., Hawse, J. R., et al. (2020) · eLife · doi:10.7554/elife.59616 · Cited by 52

Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet

Ogata, S., Ito, S., Masuda, T., & Ohtsuki, S. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2674-8 · Cited by 50

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

Stagg, D. B., Gillingham, J. R., Nelson, A. B., Lengfeld, J. E., d’Avignon, D. A., Puchalska, P., & Crawford, P. A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101269 · Cited by 48

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

Skovsø, S., Panzhinskiy, E., Kolic, J., Cen, H. H., Dionne, D. A., Dai, X.-Q., Sharma, R. B., Elghazi, L., Ellis, C. E., Faulkner, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28039-8 · Cited by 48

High-density microneedle array-based wearable electrochemical biosensor for detection of insulin in interstitial fluid

Dervisevic, M., Esser, L., Chen, Y., Alba, M., Prieto‐Simón, B., & Voelcker, N. H. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116995 · Cited by 45

Regulator of Calcineurin 1 helps coordinate whole‐body metabolism and thermogenesis

Rotter, D., Peiris, H. S., Grinsfelder, D. B., Martin, A. M., Burchfield, J. S., Parra, V., Hull, C., Morales, C. R., Jessup, C. F., Matusica, D., et al. (2018) · EMBO Reports · doi:10.15252/embr.201744706 · Cited by 46

Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism

Li, Z., Votava, J. A., Zajac, G. J. M., Nguyen, J. N., Jaimes, F. L., Ly, S. M., Brinkman, J. A., Giorgi, M. D., Kaul, S., Green, C. L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.015 · Cited by 47

Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish

Zhu, B., Lei, L., Sun, Y., Shi, X., Fu, K., Hua, J., Martyniuk, C. J., Han, J. Z., Yang, L., & Zhou, B. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c02712 · Cited by 46

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping

Rau, C. D., Parks, B. W., Wang, Y., Eskin, E., Šimeček, P., Churchill, G. A., & Lusis, A. J. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.020784 · Cited by 45

Impacts of high fat diet on ocular outcomes in rodent models of visual disease

Clarkson-Townsend, D. A., Douglass, A., Singh, A., Allen, R. S., Uwaifo, I. N., & Pardue, M. T. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108440 · Cited by 47

miR-146a regulates insulin sensitivity via NPR3

Roos, J., Dahlhaus, M., Funcke, J., Kustermann, M., Strauß, G., Halbgebauer, D., Boldrin, E., Holzmann, K., Möller, P., Trojanowski, B. M., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03699-1 · Cited by 46

Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota

Bishehsari, F., Engen, P. A., Adnan, D., Sarrafi, S., Wilber, S., Shaikh, M. W., Green, S. J., Naqib, A. D., Giron, L. B., Abdel‐Mohsen, M., et al. (2020) · Translational research · doi:10.1016/j.trsl.2020.11.007 · Cited by 44

Estrogen Mediates an Atherosclerotic-Protective Action via Estrogen Receptor Alpha/SREBP-1 Signaling

Xie, F., Li, X., Xu, Y., Cheng, D., Xia, X., Lv, X., Yuan, G., & Peng, C. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.895916 · Cited by 43

The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish

Wu, C., Shields, J. N., Akemann, C., Meyer, D. N., Connell, M. L., Baker, B. B., Pitts, D. K., & Baker, T. R. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143736 · Cited by 42

Metabolomic analysis of insulin resistance across different mouse strains and diets

Stöckli, J., Fisher‐Wellman, K. H., Chaudhuri, R., Zeng, X., Fazakerley, D. J., Meoli, C. C., Thomas, K. C., Hoffman, N. J., Mangiafico, S. P., Xirouchaki, C. E., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.818351 · Cited by 40

PGC‐1a integrates a metabolism and growth network linked to caloric restriction

Miller, K. N., Clark, J. P., Martin, S. A., Howell, P. R., Burhans, M. S., Haws, S. A., Johnson, N. B., Rhoads, T. W., Pavelec, D. M., Eliceiri, K. W., et al. (2019) · Aging Cell · doi:10.1111/acel.12999 · Cited by 38

Murine Genetic Background Overcomes Gut Microbiota Changes to Explain Metabolic Response to High-Fat Diet

Safari, Z., Bruneau, A., Monnoye, M., Mariadassou, M., Philippe, C., Zatloukal, K., & Gérard, P. (2020) · Nutrients · doi:10.3390/nu12020287 · Cited by 26

Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure

Perez, M. V., Pavlović, A., Shang, C., Wheeler, M. T., Miller, C. L., Liu, J., Dewey, F. E., Pan, S., Thanaporn, P., Absher, D., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.09.061 · Cited by 36

Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle

Egami, R., Kokaji, T., Hatano, A., Yugi, K., Eto, M., Morita, K., Ohno, S., Fujii, M., Hironaka, K., Uematsu, S., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102217 · Cited by 39

“Green”-synthesized zinc oxide nanoparticles and plant extracts: A comparison between synthesis processes and antihyperglycemic activity

Kambale, E. K., Katemo, F. M., Quetin‐Leclercq, J., Memvanga, P. B., & Beloqui, A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122715 · Cited by 34

The phospholipase A2 family’s role in metabolic diseases: Focus on skeletal muscle

Cervera, I. P., Gabriel, B. M., Aldiss, P., & Morton, N. M. (2021) · Physiological Reports · doi:10.14814/phy2.14662 · Cited by 33

Chromatin Modifications Associated With Diabetes and Obesity

Schones, D. E., Leung, A., & Natarajan, R. D. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305041 · Cited by 32

How mice are indispensable for understanding obesity and diabetes genetics

Attie, A., Churchill, G. A., & Nadeau, J. H. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000321 · Cited by 33

Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR [S]

Norheim, F., Bjellaas, T., Hui, S. T. Y., Krishnan, K. C., Lee, J. J., Gupta, S., Pan, C., Hasin-Brumshtein, Y., Parks, B. W., Li, D., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m081398 · Cited by 32

Microencapsulated pomegranate peel extract induces mitochondrial complex IV activity and prevents mitochondrial cristae alteration in brown adipose tissue in mice fed on a high-fat diet

Echeverría, F., Patino, P. A. J., Castro‐Sepúlveda, M., Bustamante, A., Concha, P. A. G., Poblete-Aro, C., Valenzuela, R., & García‐Díaz, D. F. (2020) · British Journal Of Nutrition · doi:10.1017/s000711452000481x · Cited by 34

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

Norheim, F., Krishnan, K. C., Bjellaas, T., Vergnes, L., Pan, C., Parks, B. W., Meng, Y., Lang, J., Ward, J. A., Reue, K., et al. (2021) · Molecular Systems Biology · doi:10.15252/msb.20209684 · Cited by 29

Nutritional systems biology of type 2 diabetes

Zhao, Y., Barrere‐Cain, R., & Yang, X. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0481-3 · Cited by 31

Humanity in a Dish: Population Genetics with iPSCs

Warren, C. R., & Cowan, C. A. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.09.006 · Cited by 27

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity

Pamir, N., Pan, C., Plubell, D. L., Hutchins, P. M., Tang, C., Wimberger, J., Irwin, A. D., Vallim, T. Q. D. A., Heinecke, J. W., & Lusis, A. J. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m090555 · Cited by 29

Thermogenic profiling using magnetic resonance imaging of dermal and other adipose tissues

Kasza, I., Hernando, D., Roldán‐Alzate, A., Alexander, C. M., & Reeder, S. B. (2016) · JCI Insight · doi:10.1172/jci.insight.87146 · Cited by 31

Comprehensive evaluation of disparities in cardiometabolic and reproductive risk between Hispanic and White women with polycystic ovary syndrome in the United States: a systematic review and meta-analysis

Kazemi, M., Kim, J. Y., Wan, C., Xiong, J. D., Parry, S. A., Azziz, R., & Lujan, M. E. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.07.032 · Cited by 29

The Ameliorating Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are SIRT1-Dependent: Evidence from Hepatic-Specific SIRT1 Heterozygous Mutant C57BL/6 Mice

Yin, Y., Li, D., Liu, F., Wang, X., Cui, Y., Li, S., & Li, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01461 · Cited by 27

Noggin depletion in adipocytes promotes obesity in mice

Blázquez‐Medela, A. M., Jumabay, M., Rajbhandari, P., Sallam, T., Guo, Y., Yao, J., Vergnes, L., Reue, K., Zhang, L., Yao, Y., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.004 · Cited by 26

Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice

Moore, T. M., Lee-Ødegård, S., Olsén, T., Morselli, M., Strumwasser, A. R., Lin, A. J., Zhou, Z., Abrishami, A. D., Garcia, S. M., Bribiesca, J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112499 · Cited by 27

The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes

Bond, S. T., Moody, S. C., Liu, Y., Civelek, M., Villanueva, C. J., Gregorevic, P., Kingwell, B. A., Hevener, A. L., Lusis, A. J., Henstridge, D. C., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00394.2018 · Cited by 23

Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity

Patra, D., Ramprasad, P., Sharma, S., Dey, U., Kumar, V., Singh, S., Dasgupta, S., Kumar, A. A., Tikoo, K., & Pal, D. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107328 · Cited by 27

A PPARγ/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice

Zhang, Z., Cui, Y., Su, V., Wang, D., Tol, M. J. P. M., Cheng, L., Wu, X., Kim, J., Rajbhandari, P., Zhang, S., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170072 · Cited by 24

E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia

Yang, C.-H., Mangiafico, S. P., Waibel, M., Loudovaris, T., Loh, K., Thomas, H. E., Morahan, G., & Andrikopoulos, S. (2020) · Diabetologia · doi:10.1007/s00125-020-05137-0 · Cited by 22

Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Cao, Y., Aquino-Martínez, R., Hutchison, E. R., Allayee, H., Lusis, A. J., & Rey, F. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101557 · Cited by 26

Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation

Aflatounian, A., Paris, V. R., Richani, D., Edwards, M. C., Cochran, B. J., Ledger, W. L., Gilchrist, R. B., Bertoldo, M. J., Wu, L. E., & Walters, K. A. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101583 · Cited by 23

Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice

Marcouiller, F., Jochmans‐Lemoine, A., Ganouna‐Cohen, G., Mouchiroud, M., Laplante, M., Marette, A., Bairam, A., & Joseph, V. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00272.2020 · Cited by 23

High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains

Buckley, T. N., Omotola, O. B., Archer, L. A., Rostron, C. R., Kamineni, E. P., Llanora, J., Chalfant, J. M., Lei, F., Slade, E., & Pendergast, J. S. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00150.2020 · Cited by 21

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

Molendijk, J., Blazev, R., Mills, R. J., Ng, Y., Watt, K. I., Chau, D., Gregorevic, P., Crouch, P. J., Hilton, J. B. W., Lisowski, L., et al. (2022) · eLife · doi:10.7554/elife.82951 · Cited by 19

Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

Zhou, M., Tamburini, I. J., Van, C., Molendijk, J., Nguyen, C. M., Chang, I. Y.-Y., Johnson, C., Vélez, L. M., Cheon, Y., Yeo, R. X., et al. (2023) · eLife · doi:10.7554/elife.88863 · Cited by 24

Susceptibility of different mouse strains to peri‐implantitis

Hiyari, S., Naghibi, A., Wong, R. L., Sadreshkevary, R., Yi‐Ling, L., Tetradis, S., Camargo, P. M., & Pirih, F. Q. M. (2017) · Journal of Periodontal Research · doi:10.1111/jre.12493 · Cited by 22

sFlt-1 upregulates endoplasmic reticulum stress marker XBP1 in trophoblast cells

Mochan, S., Bhatla, N., Rani, N., Gupta, S., Saxena, S. A., Arora, P., & Dhingra, R. (2017) · Placenta · doi:10.1016/j.placenta.2017.07.236

Genetic modifiers of the insulin resistance phenotype in mice.

Kido, Y., Philippe, N., Schäffer, A. A., & Accili, D. (2000) · Diabetes · doi:10.2337/diabetes.49.4.589 · Cited by 73

Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin Resistance

Almind, K., Kulkarni, R., Lannon, S. M., & Kahn, C. R. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1535 · Cited by 53

Genetics of insulin resistance and diabetes in mice.

Attie, A., Ranheim, T., Nadler, S. T., Stoehr, J. P., Schueler, K. L., Rabaglia, M. E., & Ntambi, J. M. (2000)

Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice

Almind, K., & Kahn, C. R. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3274 · Cited by 254