The DOI matches its Crossref record; 69 of the 70 references it cites were found in a registry or an index.
Suppression of Insulin Production and Secretion by a Decretin Hormone
Open accessAbstract
Decretins, hormones induced by fasting that suppress insulin production and secretion, have been postulated from classical human metabolic studies. From genetic screens, we identified Drosophila Limostatin (Lst), a peptide hormone that suppresses insulin secretion. Lst is induced by nutrient restriction in gut-associated endocrine cells. limostatin deficiency led to hyperinsulinemia, hypoglycemia, and excess adiposity. A conserved 15-residue polypeptide encoded by limostatin suppressed secretion by insulin-producing cells. Targeted knockdown of CG9918, a Drosophila ortholog of Neuromedin U receptors (NMURs), in insulin-producing cells phenocopied limostatin deficiency and attenuated insulin suppression by purified Lst, suggesting CG9918 encodes an Lst receptor. NMUR1 is expressed in islet β cells, and purified NMU suppresses insulin secretion from human islets. A human mutant NMU variant that co-segregates with familial early-onset obesity and hyperinsulinemia fails to suppress insulin secretion. We propose Lst as an index member of an ancient hormone class called decretins, which suppress insulin output.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In addition to this, NmU is likely to regulate insulin secretion; the G-protein-coupled NmU receptor 1 (NmUR1) is expressed in pancreatic islets and its simulation dose dependently decreased insulin release.230, 231”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [231]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Moreover, knockdown of the fly NmUR orthologue not only reproduced the consequences of limostatin deficiency but also diminished its insulin-suppressing ability.”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [231]
The cited source says what the claim attributes to it.
In the citing paper
“A very recent study showed231 that the peptide hormone limostatin, which is expressed in Drosophila melanogaster, also reduces insulin secretion and its absence caused hyperinsulinemia, hypoglycemia and obesity.”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [231]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
The biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Tian, L., Hires, S. A., Mao, T., Huber, D., Chiappe, M. E., Chalasani, S. H., Petreanu, L., Akerboom, J., McKinney, S. A., Schreiter, E. R., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1398 · Cited by 1,967
Pharmacology, physiology, and mechanisms of incretin hormone action.
Campbell, J. E., & Drucker, D. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.008 · Cited by 1,500
Fasting: molecular mechanisms and clinical applications
Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425
Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064
Self-citationHormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
The BDGP Gene Disruption Project
Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., Evans-Holm, M. E., Hiesinger, P. R., Schulze, K. L., Rubin, G. M., et al. (2004) · Genetics · doi:10.1534/genetics.104.026427 · Cited by 864
Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822
A nutrient sensor mechanism controls Drosophila growth
Colombani, J., Raisin, S., Pantalacci, S., Radimerski, T., Montagne, J., & Léopold, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00713-x · Cited by 809
Flagged first, then by citations
1 of the 70 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Hofmeister, 1890, Ueber Resorption und Assimilation der Nährstoffe. Arch. Für Exp, Pathol. Und Pharmakologie, 26, 355
Cited by
Sorted by citations
Items 101–149 of 149
Sadaqat, Z., Kaushik, S., & Kain, P. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96503 · Cited by 11
Ensho, T., Maruyama, K., Qattali, A. W., Yasuda, M., Uemura, R., Murakami, N., & Nakahara, K. (2019) · Journal of Veterinary Medical Science · doi:10.1292/jvms.19-0320 · Cited by 5
Rizzo, M. J., & Johnson, E. C. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.019 · Cited by 5
Islet Function and Insulin Secretion
Jones, P. M., & Persaud, S. J. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch6 · Cited by 5
Ragionieri, L. (2025) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2025.104347 · Cited by 4
Drosophila melanogaster Limostatin and Its Human Ortholog Promote West Nile Virus Infection
Mead, E. B., Lee, M.-Y., Trammell, C. E., & Goodman, A. G. (2024) · Insects · doi:10.3390/insects15060446 · Cited by 3
Islet Function and Insulin Secretion
Jones, P. M., & Persaud, S. J. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch7 · Cited by 3
Structures and functions of insulin-like peptides in insects
Okamoto, N., & Mizoguchi, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95424-2.00020-0 · Cited by 2
Understanding diabetes and its complications through the lens of Drosophila
Bevinakoppamath, S., Srinivas, A., Umesha, C. G., Prashant, A., Singh, A., & Rao, V. K. (2025) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2025.105017 · Cited by 3
A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signaling
Bai, L., Montagne, J., Ramos, C. I., & Leulier, F. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003911 · Cited by 2
Endocrine Control of Lipid Metabolism
Krishnan, N. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_807 · Cited by 2
Anti-incretin Effect: A Missing Link between Obesity, Diabetes, and Metabolic Surgery
Koufakis, T., Karras, S. Ν., & Kotsa, K. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_15 · Cited by 2
Endocrine Control of Lipid Metabolism
Krishnan, N. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-04842-4_807 · Cited by 1
The interplay of insulin signaling and neurotransmitters on sleep in Drosophila
Rennick-Zuefle, K., Weljie, A. M., & Kain, P. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101252 · Cited by 1
Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity
Pujari, N., Chevrier, K., Turriff, N., Al-Tahir, Y., Shahi, D., Gorjan, A. S., Li, A. S. O., Jois, S., Doná, E., Ferrari, M., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116097 · Cited by 1
Novel decretin hormone identified
Crunkhorn, S. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4601 · Cited by 1
Gautam, P., Pattanshetti, S., & Rayate, N. V. (2020) · Indian Journal of Surgery · doi:10.1007/s12262-020-02657-2 · Cited by 2
Nutritional state-dependent modulation of Insulin-Producing Cells in DrosophilaPreprint
Bisen, R. S., Iqbal, F. M., Cascino-Milani, F., Bockemühl, T., & Ache, J. M. (2024) · eLife · doi:10.7554/elife.98514.2 · Cited by 2
Regulation of endoplasmic reticulum stress in adipose tissue metabolism
Voyias, P. D. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33705232
卯木, 智., & 前川, 聡. (2018) · 糖尿病 · doi:10.11213/tonyobyo.61.110
Kunz-Martínez, W., & Pacheco, A. I. P. (2018) · Revista Colombiana de Cirugía · doi:10.30944/20117582.88
Rodríguez, M. V., & Frechtel, G. D. (2016) · Revista de la Sociedad Argentina de Diabetes · doi:10.47196/diab.v50i3.44
Trinh, I. (2017) · TSpace (University of Toronto)
Nakazato, M. (2020) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.109.445
Hughson, B. N. (2018) · TSpace (University of Toronto)
Sizes, proportions and environment
Léopold, P. (2021) · Comptes Rendus Biologies · doi:10.5802/crbiol.48
Limostatin—a decretin—suppresses insulin production
(2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.20
Pleiotropic fitness effects of a Drosophila odorant-binding protein
Mokashi, S. S., Shankar, V., Johnstun, J. A., Mackay, T. F. C., & Anholt, R. R. H. (2022) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkac307
Therapeutic management on diabetes mellitus in canine
Choudhary, S., Rolania, S., Mohammed, N., Meena, D. S., Nagar, J. K., & Jangid, S. K. (2024) · International Journal of Advanced Biochemistry Research · doi:10.33545/26174693.2024.v8.i1f.462
Beslenme ve Hastalık Modellemelerinde Drosophila melanogaster’in Yeri ve Önemi
Taysi, S., & Çeti̇n, B. (2025) · Muş Alparslan Üniversitesi Fen Bilimleri Dergisi · doi:10.18586/msufbd.1580717
Noro, F., Marotta, A., Costanzo, S., Izzi, B., Gialluisi, A., Curtis, A. D., Pepe, A., Grossi, S., Castelnuovo, A. F. D., Cerletti, C., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13081906
Tian, M., Sun, S., Meng, Q., Li, J., Li, X., Ren, S., Huang, Z., Du, S., & Wang, Y. (2025) · Current Drug Targets · doi:10.2174/0113894501397622250801062050
Bur, H., Hukkanen, J., Savolainen, M. J., Koivukangas, V., & Karttunen, T. J. (2025) · Physiological Reports · doi:10.14814/phy2.70489
Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinismPreprint
Lithovius, V., Montaser, H., Saarimäki-Vire, J., Ibrahim, H., Barsby, T., Balboa, D., & Otonkoski, T. (2025) · bioRxiv · doi:10.1101/2025.10.02.680116
A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signallingPreprint
Bai, L., Montagne, J., Ramos, C., & Leulier, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.06.687047
Luo, Y., Chen, N., Gao, Y., Luo, W., Liu, S., Li, Y., Wang, H., Gao, X., Jiawei, C., Ye, H., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2520504123 · Cited by 1
La signalisation insuline comme garant de la fonction barrière intestinale
Gueddouri, D. (2021) · theses.fr (ABES) · doi:10.70675/8371f5a7zb0c3z4f82z83e9z236d0eedb3f1
Localization of Peptide Hormone/Neuropeptide-Producing Cells in Insects
Tanaka, Y. (2026) · Entomology monographs · doi:10.1007/978-981-95-7510-7_5
Diversity of Insect Peptide Hormones/Neuropeptides
Mizoguchi, A. (2026) · Entomology monographs · doi:10.1007/978-981-95-7510-7_2
Sifoglu, D., Pereira, B., DeGregory, C., Shah, R., Maier, W., Guan, J., Clark, I., Patel, D. S., Ch'ng, Q.-L., & Alcedo, J. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012190
Lithovius, V., Montaser, H., Saarimäki‐Vire, J., Ibrahim, H., Barsby, T., Balboa, D., & Otonkoski, T. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag055
The gut takes it all: Enteroendocrine control of developmental growth
Cordero, J. B. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003921
Nässel, D. R. (2026) · The Journal of Comparative Neurology · doi:10.1002/cne.70218
Metadata
- Authors
- Alfa, R. W., Park, S., Skelly, K.-R., Poffenberger, G., Jain, N., Gu, X., Kockel, L., Wang, J., Liu, Y., Powers, A. C., & Kim, S. K.
- Affiliations
- Stanford Medicine (US)
- Vanderbilt University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kim, Seung K.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 21
- Issue
- 2
- Pages
- 323-334
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4349554
- OpenAlex
- W2071073520
- Cited by
- 150
- References
- 70
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 10 · 2023: 3 · 2022: 12 · 2021: 19 · 2020: 14 · 2019: 16 · 2018: 11 · 2017: 9 · 2016: 24 · 2015: 9
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-02-06)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p60dk020593-31)
- Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center
- National Institute of Mental Health (T32MH020016)
- National Institute of General Medical Sciences (R01GM084947)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60-DK020593, U01DK089572, DK-89572, DK072473, DK 20593, UC4DK104211, U01DK072473, P30DK020593)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- insulin secretion, insulin production, neuromedin U, insulin-producing cells, gastrointestinal endocrine cells, nutrient restriction, hyperinsulinemia, hypoglycemia, adiposity, Drosophila, pancreatic beta cells, peptide hormone receptors
- MeSH terms
- Insulin Secretion, Adult, Animals, Child, Preschool, Drosophila, Hormones, Humans, Insulin, Islets of Langerhans, Middle Aged, Neuropeptides, Receptors, Neurotransmitter, Drosophila Proteins, Peptide Hormones, Endocrine Cells, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
