The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents
Open accessAbstract
SUMMARY The altered metabolism of tumor cells confers a selective advantage for survival and proliferation, and studies have shown that targeting such metabolic shifts may be a useful therapeutic strategy. We developed an intensely fluorescent, rapidly responsive, pH-resistant, genetically encoded sensor of wide dynamic range, denoted SoNar, for tracking cytosolic NAD+ and NADH redox states in living cells and in vivo. SoNar responds to subtle perturbations of various pathways of energy metabolism in real-time, and allowed high-throughput screening for new agents targeting tumor metabolism. Among > 5,500 unique compounds, we identified KP372-1 as a potent NQO1-mediated redox cycling agent that produced extreme oxidative stress, selectively induced cancer cell apoptosis and effectively decreased tumor growth in vivo. This study demonstrates that genetically encoded sensor-based metabolic screening could serve as a valuable approach for drug discovery.
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Cited by
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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
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Complementation of mitochondrial electron transport chain by manipulation of the NAD + /NADH ratio
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NAD(+) in aging: molecular mechanisms and translational implications
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Metadata
- Authors
- Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H.-M., Huang, X., Yang, K., Zhu, Q., Wang, X., Yi, J., Zhu, L., Qian, X., Chen, L., Tang, Y., Loscalzo, J., & Yang, Y.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 21
- Issue
- 5
- Pages
- 777-789
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1894322524
- Cited by
- 433
- References
- 36
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H.-M., Huang, X., Yang, K., Zhu, Q., Wang, X., Yi, J., Zhu, L., Qian, X., Chen, L., Tang, Y., Loscalzo, J., & Yang, Y. (2015). SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents. Cell Metabolism. https://doi.org/10.1016/j.cmet.2015.04.009
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