The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Sex Differences in Lifespan
Open accessAbstract
SUMMARY Sex differences in longevity can provide insights into novel mechanisms of aging, yet they have been little studied. Surprisingly, sex-specific longevity patterns are better known in wild animals. Evolutionary hypotheses accounting for longevity patterns in natural populations include differential vulnerability to environmental hazards, differential intensity of sexual selection and distinct patterns of parental care. Mechanistic hypotheses focus on asymmetric inheritance of sex chromosomes and mitochondria. Virtually all intensively studied species show conditional sex differences in longevity. Humans are the only species in which one sex is known to have a ubiquitous survival advantage. Paradoxically, although women live longer, they suffer greater morbidity particularly late in life. This mortality-morbidity paradox may be a consequence of greater connective tissue responsiveness to sex hormones in women. Human females’ longevity advantage may result from hormonal influences on inflammatory and immunological responses, or greater resistance to oxidative damage; current support for these mechanisms is weak.
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Cites
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Undulating changes in human plasma proteome profiles across the lifespan
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History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723
Gut microbiome pattern reflects healthy ageing and predicts survival in humans
Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J., Lapidus, J., Earls, J. C., Zimmer, A., Glusman, G., Robinson, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00348-0 · Cited by 675
Ageing hallmarks exhibit organ-specific temporal signatures
Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature · doi:10.1038/s41586-020-2499-y · Cited by 671
Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice
Newman, J. C., Covarrubias, A. J., Zhao, M., Yu, X., Gut, P., Ng, C.-P., Huang, Y., Haldar, S., & Verdin, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.004 · Cited by 493
Metadata
- Authors
- Austad, S. N., & Fischer, K. E.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 23
- Issue
- 6
- Pages
- 1022-1033
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2436467819
- Cited by
- 593
- References
- 107
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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