Sweet Sixteenth for ChREBP: Established Roles and Future Goals
Open accessAbstract
With the identification of ChREBP in 2001, our interest in understanding the molecular control of carbohydrate sensing has surged. While ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease. Celebrating its sweet sixteenth birthday, we review here the current knowledge about the function and regulation of ChREBP throughout usual and less explored tissues, to recapitulate ChREBP's role as a whole-body glucose sensor.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Xylulose-5-phosphate activates ChREBP and promotes its binding to carbohydrate response element sites in promoters of target genes, including FGF21.
“An intermediate in this pathway, xylulose-5-phosphate, activates ChREBP (1) and promotes its binding to the carbohydrate response element sites in the promoters of target genes, including FGF21 (53, 130).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [1]
Stimulation of FGF21 production by carbohydrates is mediated by the transcription factor ChREBP.
“The stimulation of FGF21 production by carbohydrates is mediated by the transcription factor carbohydrate-response element-binding protein (ChREBP).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [1]
Cites
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
PPARγ signaling and metabolism: the good, the bad and the future
Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works
Sirtuins as regulators of metabolism and healthspan
Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008 · see citing works
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585 · see citing works
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N. P., Rieder, M. J., Cooper, G. M., Roos, C., Voight, B. F., Havulinna, A. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.75 · Cited by 1,386 · see citing works
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
Yore, M. M., Syed, I., Moraes‐Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.035 · Cited by 845 · see citing works
Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401516101 · Cited by 786 · see citing works
Foretz, M., Guichard, C., Ferré, P., & Foufelle, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12737 · Cited by 748 · see citing works
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., & Uyeda, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161284298 · Cited by 682 · see citing works
ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
Kim, J. B., Wright, H. M., Wright, M., & Spiegelman, B. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4333 · Cited by 670 · see citing works
Crosstalk between components of circadian and metabolic cycles in mammals
Asher, G., & Schibler, U. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.006 · Cited by 601 · see citing works
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Herman, M. A., Peroni, O. D., Villoria, J., Schön, M. R., Abumrad, N. A., Blüher, M., Klein, S., & Kahn, B. B. (2012) · Nature · doi:10.1038/nature10986 · Cited by 599 · see citing works
Calvisi, D. F., Wang, C., Ho, C., Ladu, S., Lee, S. A., Mattu, S., Destefanis, G., Delogu, S., Zimmermann, A., Ericsson, J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.006 · Cited by 598 · see citing works
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers, J. C., Study, D. G. R. A. M.-A. (., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Hólm, H., Sanna, S., Kavousi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.970 · Cited by 546 · see citing works
Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works
The nuclear receptor LXR is a glucose sensor
Mitro, N., Mak, P. A., Vargas, L., Godio, C., Hampton, E. N., Molteni, V., Kreusch, A., & Sáez, E. (2006) · Nature · doi:10.1038/nature05449 · Cited by 525 · see citing works
Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 520 · see citing works
Gunton, J. E., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W. J., Tseng, Y., Roberson, R. S., Ricordi, C., O’Connell, P. J., Gonzalez, F. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.027 · Cited by 489 · see citing works
Viollet, B., Guigas, B., Leclerc, J., Hébrard, S., Lantier, L., Mounier, R., Andréelli, F., & Foretz, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01970.x · Cited by 486 · see citing works
Dentin, R., Pégorier, J. P., Benhamed, F., Foufelle, F., Ferré, P., Fauveau, V., Magnuson, M. A., Girard, J. R., & Postic, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312475200 · Cited by 444 · see citing works
Self-citationDietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
Kirk, E., Reeds, D. N., Finck, B. N., Mayurranjan, M. S., Patterson, B. W., & Klein, S. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.048 · Cited by 440 · see citing works
Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice
Dentin, R., Benhamed, F., Hainault, I., Fauveau, V., Foufelle, F., Dyck, J. R. B., Girard, J. R., & Postic, C. (2006) · Diabetes · doi:10.2337/db06-0200 · Cited by 429 · see citing works
Self-citationMechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription
Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., & Uyeda, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107895200 · Cited by 424 · see citing works
Benhamed, F., Denechaud, P.-D., Lemoine, M., Robichon, C., Moldes, M., Bertrand-Michel, J., Ratziu, V., Serfaty, L., Housset, C., Capeau, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci41636 · Cited by 408 · cited 3× · see citing works
“Although other reports also suggest direct promoter binding as a mechanism for ChREBPmediated gene repression (Boergesen et al., 2011; Noordeen et al., 2010), this mechanism should be regarded with caution as it has been recently challenged (Schmidt et al., 2016).”
BackgroundSelf-citationKabashima, T., Kawaguchi, T., Wadzinski, B. E., & Uyeda, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730817100 · Cited by 401 · see citing works
Feasting, fasting and fermenting: glucose sensing in yeast and other cells
Johnston, M. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(98)01637-0 · Cited by 387 · see citing works
Oberbach, A., Bossenz, Y., Lehmann, S., Niebauer, J., Adams, V., Paschke, R., Schön, M. R., Blüher, M., & Punkt, K. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1854 · Cited by 385 · see citing works
ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver
Ma, L., Robinson, L. N., & Towle, H. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601576200 · Cited by 373 · see citing works
Kawaguchi, T., Takenoshita, M., Kabashima, T., & Uyeda, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231370798 · Cited by 373 · see citing works
MECHANISMS BY WHICH CARBOHYDRATES REGULATE EXPRESSION OF GENES FOR GLYCOLYTIC AND LIPOGENIC ENZYMES
Girard, J. R., Ferré, P., & Foufelle, F. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.325 · Cited by 357 · see citing works
FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.003 · Cited by 347 · see citing works
FGF21 Regulates Sweet and Alcohol Preference
Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.008 · Cited by 342 · see citing works
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
Kooner, J. S., Chambers, J. C., Aguilar-Salinas, C. A., Hinds, D. A., Hyde, C. L., Warnes, G. R., Pérez, F. J. G., Frazer, K. A., Elliott, P., Scott, J., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.61 · Cited by 329 · see citing works
Dentin, R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25256 · Cited by 315 · see citing works
Proctor, G., Jiang, T., Iwahashi, M., Wang, Z., Li, J., & Levi, M. (2006) · Diabetes · doi:10.2337/db05-0603 · Cited by 303 · see citing works
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W. M., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., et al. (2013) · Nature Communications · doi:10.1038/ncomms2537 · Cited by 302 · see citing works
Bricambert, J., Miranda, J., Benhamed, F., Girard, J. R., Postic, C., & Dentin, R. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41624 · Cited by 299 · see citing works
Self-citationBrookheart, R. T., Michel, C. I., & Schaffer, J. E. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.011 · Cited by 279 · see citing works
Glucose-sensing neurons of the hypothalamus
Burdakov, D., Luckman, S. M., & Verkhratsky, A. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1763 · Cited by 267 · see citing works
Glucose Regulation of Gene Transcription
Vaulont, S., Vasseur-Cognet, M., & Kahn, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000016200 · Cited by 266 · see citing works
Lodhi, I. J., Yin, L., Jensen-Urstad, A. P. L., Funai, K., Coleman, T., Baird, J. H., Ramahi, M. K. E., Razani, B., Song, H., Hsu, F., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.013 · Cited by 245 · see citing works
Schumann, G., Liu, C., O’Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611243113 · Cited by 241 · see citing works
Routh, V. H. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00761-8 · Cited by 237 · see citing works
Osorio, J. S., Lohakare, J., & Bionaz, M. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00016.2015 · Cited by 235 · see citing works
Fructose ingestion acutely stimulates circulating FGF21 levels in humans
Dushay, J. R., Toschi, E., Mitten, E. K., Fisher, F. M., Herman, M. A., & Maratos-Flier, E. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.09.008 · Cited by 233 · see citing works
Tanaka, T., Ngwa, J. S., van Rooij, F. J., Zillikens, M. C., Wojczynski, M. K., Frazier-Wood, A. C., Houston, D. K., Kanoni, S., Lemaitre, R. N., Luan, J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.052183 · Cited by 226 · cited 1× · see citing works
“These findings support earlier reports associating variants in the FGF21 locus with increased carbohydrate preference in human cohorts (Chu et al., 2013; Tanaka et al., 2013).”
Diraison, F., Dusserre, E., Vidal, H., Sothier, M., & Beylot, M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e46 · Cited by 222 · see citing works
Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
Jiang, L., Xiao, L., Sugiura, H., Huang, X., Ali, A., Kuro‐o, M., DeBerardinis, R. J., & Boothman, D. A. (2014) · Oncogene · doi:10.1038/onc.2014.321 · Cited by 221 · see citing works
Girousse, A., Tavernier, G., Valle, C., Moro, C., Mejhert, N., Dinel, A., Houssier, M., Roussel, B., Besse‐Patin, A., Combes, M., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001485 · Cited by 221 · see citing works
Cha‐Molstad, H., Saxena, G., Chen, J., & Shalev, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010504 · Cited by 219 · see citing works
Shih, H., Liu, Z., & Towle, H. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21991 · Cited by 218 · see citing works
Stoeckman, A. K., Ma, L., & Towle, H. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311301200 · Cited by 218 · see citing works
ChREBP regulates fructose-induced glucose production independently of insulin signaling
Kim, M.-S., Krawczyk, S. A., Doridot, L., Fowler, A. J., Wang, J. X., Trauger, S. A., Noh, H.-L., Kang, H. J., Meissen, J. K., Blatnik, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81993 · Cited by 212 · see citing works
O -GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
Guinez, C., Filhoulaud, G., Benhamed, F., Marmier, S., Dubuquoy, C., Dentin, R., Moldes, M., Burnol, A., Yang, X., Lefebvre, T., et al. (2011) · Diabetes · doi:10.2337/db10-0452 · Cited by 211 · see citing works
Self-citationThe Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
Farese, R. V., Zechner, R., Newgard, C. B., & Walther, T. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.004 · Cited by 207 · see citing works
Novel locus including FGF21 is associated with dietary macronutrient intake
Chu, A. Y., Workalemahu, T., Paynter, N. P., Rose, L. M., Giulianini, F., Tanaka, T., Ngwa, J. S., Qi, Q., Curhan, G. C., Rimm, E. B., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt032 · Cited by 195 · see citing works
Iizuka, K., Miller, B., & Uyeda, K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00027.2006 · Cited by 195 · see citing works
Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes
Ma, L., Tsatsos, N. G., & Towle, H. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413063200 · Cited by 190 · see citing works
Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
Iizuka, K., Takeda, J., & Horikawa, Y. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.053 · Cited by 187 · see citing works
Foufelle, F., Gouhot, B., Pégorier, J. P., Perdereau, D., Girard, J. R., & Ferré, P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36717-1 · Cited by 186 · see citing works
Dentin, R., Tomás‐Cobos, L., Foufelle, F., Leopold, J. A., Girard, J. R., Postic, C., & Ferré, P. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.019 · Cited by 177 · see citing works
Self-citationGlucose-Dependent Transcriptional Regulation by an Evolutionarily Conserved Glucose-Sensing Module
Li, M. V., Chang, B. H.-J., Imamura, M., Poungvarin, N., & Chan, L. (2006) · Diabetes · doi:10.2337/db05-0822 · Cited by 177 · see citing works
CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
Noriega, L. G., Feige, J. N., Cantó, C., Yamamoto, H., Yu, J., Herman, M. A., Mataki, C., Kahn, B. B., & Auwerx, J. H. (2011) · EMBO Reports · doi:10.1038/embor.2011.151 · Cited by 172 · see citing works
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
Tang, Y., Wallace, M., Sánchez-Gurmaches, J., Hsiao, W., Li, H., Lee, P. L., Vernia, S., Metallo, C. M., & Guertin, D. A. (2016) · Nature Communications · doi:10.1038/ncomms11365 · Cited by 172 · see citing works
Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.
Wada, J., & Nakatsuka, A. (2016) · PubMed · doi:10.18926/amo/54413 · Cited by 157 · see citing works
Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M., Mellitzer, G., et al. (2010) · Development · doi:10.1242/dev.041673 · Cited by 155 · see citing works
Tong, X., Zhao, F., Mancuso, A., Gruber, J. J., & Thompson, C. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911316106 · Cited by 155 · see citing works
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
Lodhi, I. J., Wei, X., & Semenkovich, C. F. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.09.002 · Cited by 152 · see citing works
Isoe, T., Makino, Y., Mizumoto, K., Sakagami, H., Fujita, Y., Honjo, J., Takiyama, Y., Itoh, H., & Haneda, M. (2010) · Kidney International · doi:10.1038/ki.2010.99 · Cited by 152 · see citing works
Caron, S., Samanez, C. H., Dehondt, H., Ploton, M., Briand, O., Lien, F., Dorchies, E., Dumont, J., Postic, C., Cariou, B., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01004-12 · Cited by 151 · see citing works
Self-citationJeong, Y.-S., Kim, D., Lee, Y. S., Kim, H.-J., Han, J.-Y., Im, S., Chong, H. K., Kwon, J.-K., Cho, Y.-H., Kim, W. K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022544 · Cited by 149 · see citing works
Beaven, S. W., Matveyenko, A. V., Wroblewski, K., Chao, L. C., Wilpitz, D. C., Hsu, T. W., Lentz, J., Drew, B. G., Hevener, A. L., & Tontonoz, P. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.021 · Cited by 146 · see citing works
Role of Fat Body Lipogenesis in Protection against the Effects of Caloric Overload in Drosophila
Musselman, L. P., Fink, J. L., Ramachandran, P. V., Patterson, B. W., Okunade, A. L., Maier, E. J., Brent, M. R., TURK, J. W., & Baranski, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371047 · Cited by 144 · see citing works
Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
Montagner, A., Korecka, A., Polizzi, A., Lippi, Y., Blum, Y., Canlet, C., Tremblay-Franco, M., Gautier-Stein, A., Burcelin, R., Yen, Y.-C., et al. (2016) · Scientific Reports · doi:10.1038/srep20127 · Cited by 137 · see citing works
Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)
Li, M. V., Chen, W., Harmancey, R., Nuotio-Antar, A. M., Imamura, M., Saha, P., Taegtmeyer, H., & Chan, L. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.028 · Cited by 132 · see citing works
Polygenic determinants of severe hypertriglyceridemia
Wang, J., Ban, M. R., Zou, G., Cao, H., Lin, T., Kennedy, B. A., Anand, S., Yusuf, S., Huff, M. W., Pollex, R. L., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn188 · Cited by 127 · see citing works
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci
Weissglas‐Volkov, D., Aguilar-Salinas, C. A., Nikkola, E., Deere, K. A., Cruz‐Bautista, I., Arellano‐Campos, O., Muñóz-Hernández, L. L., Gómez-Munguía, L., Ordóñez-Sánchez, M. L., Reddy, P. M. V. L., et al. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101461 · Cited by 117 · see citing works
Arden, C., Tudhope, S. J., Petrie, J. L., Al‐Oanzi, Z. H., Cullen, K. S., Lange, A. J., Towle, H. C., & Agius, L. (2012) · Biochemical Journal · doi:10.1042/bj20111280 · Cited by 116 · see citing works
Tsintzas, K., Jewell, K., Kamran, M., Laithwaite, D., Boonsong, T., Littlewood, J. J., Macdonald, I. A., & Bennett, A. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109892 · Cited by 111 · see citing works
Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell
Gao, N., Lay, J. E. L., Qin, W. D., Doliba, N. M., Schug, J., Fox, A. J., Smirnova, O., Matschinsky, F. M., & Kaestner, K. H. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0513 · Cited by 110 · see citing works
Zhang, D., Tong, X., VanDommelen, K., Gupta, N., Stamper, K., Brady, G. F., Meng, Z., Lin, J. D., Rui, L., Omary, M. B., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89934 · Cited by 107 · see citing works
Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP)
Sakiyama, H., Wynn, R., Lee, W.-R., Fukasawa, M., Mizuguchi, H., Gardner, K. H., Repa, J. J., & Uyeda, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804308200 · Cited by 106 · see citing works
ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
Metukuri, M. R., Zhang, P., Basantani, M. K., Chin, C., Stamateris, R. E., Alonso, L. C., Takane, K. K., Gramignoli, R., Strom, S. C., O'Doherty, R. M., et al. (2012) · Diabetes · doi:10.2337/db11-0802 · Cited by 106 · see citing works
Zhao, C., Liu, Y., Xiao, J., Liu, L., Chen, S., Mohammadi, M., McClain, C. J., Li, X., & Feng, W. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m058610 · Cited by 103 · see citing works
Kursawe, R., Caprio, S., Giannini, C., Narayan, D., Lin, A., D’Adamo, E., Shaw, M. M., Pierpont, B. M., Cushman, S. W., & Shulman, G. I. (2012) · Diabetes · doi:10.2337/db12-0889 · Cited by 100 · see citing works
Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin
Poungvarin, N., Chang, B. H.-J., Imamura, M., Chen, J., Moolsuwan, K., Sae‐Lee, C., Li, W., & Chan, L. (2015) · Endocrinology · doi:10.1210/en.2014-1666 · Cited by 99 · see citing works
Davies, M. N., O’Callaghan, B. L., & Towle, H. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801539200 · Cited by 94 · see citing works
Induction of Fatty‐Acid‐Synthase Gene Expression by Glucose in Primary Culture of Rat Hepatocytes
Prip‐Buus, C., Perdereau, D., Foufelle, F., et al. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0309i.x · Cited by 91 · see citing works
Park, M.-J., Kim, D., Lim, S.-K., Choi, J., Han, H. J., Yoon, K. C., & Park, S.-H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.530139 · Cited by 90 · see citing works
Hepatokines and non-alcoholic fatty liver disease
Lebensztejn, D. M., Flisiak-Jackiewicz, M., Białokoz-Kalinowska, I., Bobrus-Chociej, A., & Kowalska, I. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1252 · Cited by 90 · cited 1× · see citing works
“This was named the glucose-sensing module (GSM), also known as mondo conserved region (MCR), composed of a low-glucose inhibitory domain (LID) and a transactivation domain called glucose-response activation conserved element (GRACE) (Singh and Irwin, 2016) (Li et al., 2006) (Figure 1).”
BackgroundInhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
Kaushik, A., Shojaie, A., Panzitt, K., Sonavane, R., Venghatakrishnan, H., Manikkam, M., Zaslavsky, A., Putluri, V., Vasu, V. T., Zhang, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms11612 · Cited by 89 · see citing works
Poungvarin, N., Lee, J. K., Yechoor, V. K., Li, M. V., Assavapokee, T., Suksaranjit, P., Thepsongwajja, J. J., Saha, P., Oka, K., & Chan, L. (2012) · Diabetologia · doi:10.1007/s00125-012-2506-4 · Cited by 86 · see citing works
Sato, S., Jung, H., Nakagawa, T., Pawlosky, R. J., Takeshima, T., Lee, W.-R., Sakiyama, H., Laxman, S., Wynn, R., Tu, B. P., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708982 · Cited by 83 · see citing works
Brain glucose sensing in homeostatic and hedonic regulation.
Steinbusch, L., Labouèbe, G., & Thorens, B. (2015) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2015.06.005 · Cited by 81 · see citing works
He, Z., Jiang, T., Wang, Z., Levi, M., & Li, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00568.2003 · Cited by 78 · see citing works
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism
Tsatsos, N. G., & Towle, H. C. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.029 · Cited by 77 · see citing works
Merla, G., Howald, C., Antonarakis, S. E., & Reymond, A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh163 · Cited by 77 · see citing works
Ido-Kitamura, Y., Sasaki, T., Kobayashi, M., Kim, H., Lee, Y., Kikuchi, O., Yokota‐Hashimoto, H., Iizuka, K., Accili, D., & Kitamura, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047231 · Cited by 75 · see citing works
Marmier, S., Dentin, R., Daujat‐Chavanieu, M., Guillou, H., Bertrand‐Michel, J., Gerbal‐Chaloin, S., Girard, J. R., Lotersztajn, S., & Postic, C. (2015) · Hepatology · doi:10.1002/hep.27778 · Cited by 71 · see citing works
Self-citationPleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels
Li, N., van der Sijde, M. R., LifeLines Cohort Study Group, Bakker, S. J. L., Dullaart, R. P. F., van der Harst, P., Gansevoort, R. T., Elbers, C. C., Wijmenga, C., Snieder, H., et al. (2014) · Diabetes · doi:10.2337/db13-1800 · Cited by 70 · see citing works
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
Ahn, B. Y., Soundarapandian, M. M., Sessions, H., Peddibhotla, S., Roth, G. P., Li, J., Sugarman, E. D., Koo, A., Malany, S., Wang, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87382 · Cited by 68 · see citing works
The Glucose Sensor ChREBP Links De Novo Lipogenesis to PPARγ Activity and Adipocyte Differentiation
Witte, N., Muenzner, M., Rietscher, J., Knauer, M., Heidenreich, S., Nuotio-Antar, A. M., Graef, F. A., Fedders, R., Tolkachov, A., Göhring, I., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1209 · Cited by 67 · see citing works
de Luis, O., Valero, M. C., & Jurado, L. A. P. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200435 · Cited by 66 · see citing works
ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity
del Pozo, C. H., Vesperinas, G., Rubio, M. Á., Corripio‐Sánchez, R., García, A. J. T., Obregón, M.-J., & Calvo, R. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.016 · Cited by 65 · see citing works
Noordeen, N. A., Khera, T. K., Sun, G., Longbottom, E. R., Pullen, T. J., Xavier, G. D. S., Rutter, G. A., & Leclerc, I. (2009) · Diabetes · doi:10.2337/db08-0868 · Cited by 64 · see citing works
Li, J., Chi, Y., Wang, C., Wu, J., Yang, H., Zhang, D., Zhu, Y., Wang, N., Yang, J., & Guan, Y. (2011) · Hepatology · doi:10.1002/hep.24295 · Cited by 63 · see citing works
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease
Cho, K.-H., Kim, H.-J., Kamanna, V. S., & Vaziri, N. D. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.10.009 · Cited by 63 · see citing works
Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy
Clar, J., Gri, B., Caldéraro, J., et al. (2014) · Kidney International · doi:10.1038/ki.2014.102 · Cited by 62 · see citing works
A link between hepatic glucose production and peripheral energy metabolism via hepatokines
Abdul-Wahed, A., Gautier‐Stein, A., Casteras, S., Soty, M., Roussel, D., Romestaing, C., Guillou, H., Tourette, J.-A., Plèche, N., Zitoun, C., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.005 · Cited by 61 · see citing works
Self-citationChen, H., Wu, L., Li, Y., Meng, J., Lin, N., Yang, D., Zhu, Y., Li, X., Li, M., Xu, Y., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.07.021 · Cited by 61 · see citing works
Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping
Iizuka, K., & Horikawa, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.101 · Cited by 60 · see citing works
Jois, T., Chen, W., HOWARD, V. G., Harvey, R. E., Youngs, K., Thalmann, C., Saha, P., Chan, L., Cowley, M. A., & Sleeman, M. W. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.07.006 · Cited by 60 · see citing works
Burgess, S. C., Iizuka, K., Jeoung, N. H., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706540200 · Cited by 58 · see citing works
Yang, J., Robert, C. E., Burkhardt, B. R., Young, R. A., Wu, J., Gao, Z., & Wolf, B. A. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3217 · Cited by 58 · see citing works
The role of O-linked GlcNAc modification on the glucose response of ChREBP
Sakiyama, H., Fujiwara, N., Noguchi, T., Eguchi, H., Yoshihara, D., Uyeda, K., & Suzuki, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.113 · Cited by 56 · see citing works
Noordeen, N. A., Meur, G., Rutter, G. A., et al. (2012) · Diabetes · doi:10.2337/db10-1329 · Cited by 55 · see citing works
Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
Zhang, P., Kumar, A., Katz, L. S., Li, L. Q., Paulynice, M., Herman, M. A., & Scott, D. K. (2015) · Diabetes · doi:10.2337/db15-0239 · Cited by 55 · see citing works
Lou, D.-Q., Tannour‐Louet, M., Selig, L., Thomas, D., Kahn, A., & Vasseur-Cognet, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28385 · Cited by 52 · see citing works
Activation of Carbohydrate Response Element-Binding Protein by Ethanol
Liangpunsakul, S., Ross, R. A., & Crabb, D. W. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31827c2795 · Cited by 51 · see citing works
A Novel N-Terminal Domain May Dictate the Glucose Response of Mondo Proteins
McFerrin, L. G., & Atchley, W. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034803 · Cited by 50 · see citing works
Nuotio-Antar, A. M., Poungvarin, N., Li, M., Schupp, M., Mohammad, M. A., Gerard, S., Zou, F., & Chan, L. (2015) · Endocrinology · doi:10.1210/en.2015-1210 · Cited by 49 · see citing works
Adamson, A. W., Suchánková, G., Rufo, C., Nakamura, M., Terán-Garcı́a, M., Clarke, S. D., & Gettys, T. W. (2006) · Biochemical Journal · doi:10.1042/bj20060659 · Cited by 49 · see citing works
Nakagawa, T., Ge, Q., Pawlosky, R. J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.498550 · Cited by 47 · see citing works
Sarrazy, V., Sore, S., Viaud, M., Rignol, G., Westerterp, M., Ceppo, F., Tanti, J., Guinamard, R., Gautier, E. L., & Yvan‐Charvet, L. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.068 · Cited by 46 · see citing works
A Role for Astrocytes in Sensing the Brain Microenvironment and Neuro-Metabolic Integration
Teschemacher, A., Gourine, A. V., & Kasparov, S. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1562-9 · Cited by 46 · see citing works
Iizuka, K., Takeda, J., & Horikawa, Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.016 · Cited by 44 · see citing works
ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β–Cell Line
Sae‐Lee, C., Moolsuwan, K., Chan, L., & Poungvarin, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147411 · Cited by 43 · see citing works
Airley, R. E., McHugh, P., Evans, A. R., Harris, B. H. L., Winchester, L. M., Buffa, F. M., Al-Tameemi, W., Leek, R., & Harris, A. L. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.765 · Cited by 42 · see citing works
Collier, J. J., Zhang, P., Pedersen, K. B., Burke, S. J., Haycock, J. W., & Scott, D. K. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00357.2006 · Cited by 41 · see citing works
Sassu, E. D., McDermott, J. E., Keys, B. J., Esmaeili, M., Keene, A. C., Birnbaum, M. J., & DiAngelo, J. R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.08.028 · Cited by 40 · see citing works
Gu, J., Chen, J., Xu, G., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.09.010 · Cited by 40 · see citing works
PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance
Robert, C. E., Dougan, G. C., Moak, S. L., Athanason, M. G., Kuehl, M. N., Bell‐Temin, H., Stevens, S. M., & Burkhardt, B. R. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0338 · Cited by 39 · see citing works
Boergesen, M., Poulsen, L. L. C., Schmidt, S. F., Frigerio, F., Maechler, P., & Mandrup, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215467 · Cited by 38 · see citing works
Ge, Q., Huang, N. N., Wynn, R., Li, Y., Du, X., Miller, B., Zhang, H., & Uyeda, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.418855 · Cited by 38 · see citing works
Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation
Wu, W., Tsuchida, H., Kato, T., Niwa, H., Horikawa, Y., Takeda, J., & Iizuka, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.092 · Cited by 37 · see citing works
Dysregulation of hepatic fatty acid metabolism in chronic kidney disease
Jin, K., Norris, K. C., & Vaziri, N. D. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs350 · Cited by 37 · see citing works
Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter
Burkhardt, B. R., Yang, M., Robert, C. E., Greene, S. R., McFadden, K. K., Yang, J., Wu, J., Gao, Z., & Wolf, B. A. (2005) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2005.07.003 · Cited by 36 · see citing works
Wilson, C. G., Schupp, M., Burkhardt, B. R., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0379 · Cited by 36 · see citing works
Schmidt, S. F., Madsen, J. G. S., Frafjord, K. Ø., Poulsen, L. L. C., Salö, S., Boergesen, M., Loft, A., Larsen, B. D., Madsen, M. S., Holst, J. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.063 · Cited by 35 · see citing works
Aung, L.-H.-H., Yin, R., Wu, J., et al. (2014) · Scientific Reports · doi:10.1038/srep05565 · Cited by 34 · see citing works
Agius, L. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115002451 · Cited by 33 · see citing works
Fukasawa, M., Ge, Q., Wynn, R., Ishii, S., & Uyeda, K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.115 · Cited by 32 · see citing works
Yang, A.-Q., Li, D., Chi, L., & Ye, X. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.061416 · Cited by 29 · see citing works
ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells
Xavier, G. D. S., Sun, G., Qian, Q., Rutter, G. A., & Leclerc, I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.010 · Cited by 24 · see citing works
Davies, M. N., O’Callaghan, B. L., & Towle, H. C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00349.2010 · Cited by 24 · see citing works
Enhanced glucose tolerance in pancreatic derived factor (PANDER) knockout C57BL/6 mice
Moak, S. L., Dougan, G. C., MarElia, C. B., Danse, W. A., Fernandez, A. M., Kuehl, M. N., Athanason, M. G., & Burkhardt, B. R. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.016402 · Cited by 22 · see citing works
Díaz‐Moralli, S., Ramos‐Montoya, A., Marín, S., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00675.2011 · Cited by 21 · see citing works
Soggia, A., Flosseau, K., Ravassard, P., Szinnai, G., Scharfmann, R., & Guillemain, G. (2012) · Diabetologia · doi:10.1007/s00125-012-2623-0 · Cited by 19 · see citing works
Hanke, N., Scheibe, R. J., Manukjan, G., Ewers, D., Umeda, P. K., Chang, K., Kubis, H., Gros, G., & Meissner, J. D. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.12.021 · Cited by 18 · see citing works
Pan, L., Chen, Y., Huang, H., et al. (2009) · Cardiology · doi:10.1159/000226610 · Cited by 18 · see citing works
Ghasemi, A., Aghajani, H., Fallah, S., et al. (2014) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2014.5135 · Cited by 18 · see citing works
Mio acts in the Drosophila brain to control nutrient storage and feeding
Docherty, J. E. B., Manno, J. E., McDermott, J. E., & DiAngelo, J. R. (2015) · Gene · doi:10.1016/j.gene.2015.05.055 · Cited by 17 · see citing works
Guo, S., Zheng, F., Qiu, X., & Yang, N. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.06.024 · Cited by 17 · see citing works
Relationship between dyslipidemia and gene polymorphism in Tibetan population.
Zhang, L., Sun, Y., Liang, Y., et al. (2012) · PubMed · doi:10.3967/0895-3988.2012.03.008 · Cited by 16 · see citing works
Zeng, H.-X., Gu, H., Chen, C.-Q., Li, M., Xia, F., Xie, L., Liu, X.-Y., Zhang, F., Tong, X., Wang, J.-B., et al. (2016) · OncoTarget · doi:10.18632/oncotarget.9520 · Cited by 15 · see citing works
Radoviča-Spalviņa, I., Frīdmanis, D., Silamiķelis, I., Ņikitina-Zaķe, L., & Kloviņš, J. (2014) · Meta Gene · doi:10.1016/j.mgene.2014.07.006 · Cited by 13 · see citing works
Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter
Ratliff, W. A., Athanason, M. G., Chechele, A. C., Kuehl, M. N., Fernandez, A. M., MarElia, C. B., & Burkhardt, B. R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.040 · Cited by 12 · see citing works
Singh, P., & Irwin, D. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149682 · Cited by 9 · see citing works
GC–ECD analysis of S-metolachlor (Dual Gold) in cotton plant and soil in trial field
Cao, P., Liu, F., Wang, S., et al. (2007) · Environmental Monitoring and Assessment · doi:10.1007/s10661-007-9942-5 · Cited by 8 · see citing works
Seifi, M., Ghasemi, A., Namipashaki, A., et al. (2014) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The integrative biology of type 2 diabetes
Roden, M., & Shulman, G. I. (2019) · Nature · doi:10.1038/s41586-019-1797-8 · Cited by 1,167 · see citing works
mTOR signalling and cellular metabolism are mutual determinants in cancer
Mossmann, D., Park, S., & Hall, M. N. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0074-8 · Cited by 1,088 · see citing works
From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
Gastaldelli, A., & Cusi, K. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.07.002 · Cited by 455 · see citing works
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works
A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response
Iroz, A., Montagner, A., Benhamed, F., Levavasseur, F., Polizzi, A., Anthony, E., Régnier, M., Fouché, E., Lukowicz, C., Cauzac, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.065 · Cited by 128 · see citing works
Self-citationThe role of ChREBP in carbohydrate sensing and NAFLD development
Régnier, M., Carbinatti, T., Parlati, L., Benhamed, F., & Postic, C. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00809-4 · Cited by 101 · see citing works
Self-citation
- Authors
- Abdul-Wahed, A., Guilmeau, S., & Postic, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Postic, Catherine
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 26
- Issue
- 2
- Pages
- 324-341
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2741150613
- Cited by
- 231
- References
- 164
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 21 · 2023: 21 · 2022: 33 · 2021: 26 · 2020: 37 · 2019: 31 · 2018: 25 · 2017: 3
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Agency for Research (ANR-15-CE14-0026-Hepatokind)
- SFD
- EFSD-Novo Nordisk
- ANR (ANR-15-CE14-0016-Hepametol, ANR-12-BSV1-0025-ObeliP, ANR-15-CE14-0026-Hepatokind)
- FRM (DEQ20150331744)
- ChroMe Network (H2020-MSCA-ITN-2015-675610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- ChREBP, carbohydrate sensing, glucose detection, lipogenesis, metabolic regulation, hormone signaling, tissue-specific metabolism
- MeSH terms
- Animals, Glucose, Humans, Liver, Lipogenesis, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
