Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength
Open accessAbstract
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen. Evidence is accumulating that estrogen deficiency induces apoptosis in skeletal muscle contributing to loss of mass and thus strength. Estrogen sensitive processes that affect quality, i.e., force generating capacity of muscle, include myosin phosphorylation and satellite cell function. Further detailing these mechanisms and identifying additional mechanisms that underlie estrogenic effects on skeletal muscle is important foundation for the design of therapeutic strategies to minimize skeletal muscle pathologies, such as sarcopenia and dynapenia.
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Data examining nucleolar adaptation in female cohorts, particularly considering ovarian hormone fluctuations, remain scarce.
“Data specifically examining nucleolar adaptation in female cohorts, particularly considering the potential modulatory effects of fluctuations in ovarian hormones on mechanotransduction, remain scarce [213,214,215].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [215]
The Introduction says aged female rodents are infrequently used to study how estrogen loss affects muscle strength. The muscle protein turnover section discusses menstrual-cycle hormone fluctuations, but neither passage addresses nucleolar adaptation or whether data on hormone-modulated mechanotransduction in female cohorts are scarce. Searches for nucleolar adaptation, ribosome biogenesis, and mechanical loading found no passage establishing that claim. (LLM, conf=0.74)
Experimental — accuracy not yet measuredSarcopenia is a critical determinant of frailty leading to loss of autonomy and functionality in daily activities, and it increases hospitalization, osteoarthritis, osteoporosis, and risk of institutionalization.
“Furthermore, it is a critical determinant of frailty that leads to loss of autonomy and functionality in daily activities. Besides, sarcopenia increases hospitalization, osteoarthritis, osteoporosis, and the risk of institutionalization [30].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [30]
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Research works printed but not linked: 2
- [96]Collins BC,, Deletion of estrogen receptor alpha in skeletal muscle results in impaired contractility in female mice. Journal of applied physiology, 2018 124(4): p. 980– 992. 29345963 PMC5972463
- [121]Stupka N,, Gender differences in muscle inflammation after eccentric exercise. Journal of applied physiology, 2000 89(6): p. 2325– 32. 11090586
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- Authors
- Collins, B. C., Laakkonen, E. K., & Lowe, D. A.
- Affiliations
- University of Utah (US)
- University of Jyväskylä (FI)
- University of Minnesota (US)
- Corresponding author
- Lowe, Dawn A.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 123
- Pages
- 137-144
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- PMC
- PMC6491229
- OpenAlex
- W2930185787
- Cited by
- 227
- References
- 134
- Citations by year
- 2026: 42 · 2025: 45 · 2024: 41 · 2023: 26 · 2022: 31 · 2021: 22 · 2020: 13 · 2019: 7
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (R01-AG031743)
- Academy of Finland (309504)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- estrogen deficiency, skeletal muscle strength, aging, ovarian failure, sarcopenia, dynapenia, muscle mass loss, muscle quality, apoptosis, myosin phosphorylation, satellite cells, sex differences in aging, force generation
- MeSH terms
- Aging, Estrogens, Female, Humans, Apoptosis, Muscle, Skeletal, Proteasome Endopeptidase Complex, Muscle Strength, Ubiquitination
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