Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,299 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

Renier, N., Wu, Z., Simon, D. J., Yang, J. H., Ariel, P., & Tessier‐Lavigne, M. (2014) · Cell · doi:10.1016/j.cell.2014.10.010 · Cited by 1,838 · see citing works

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E. (2013) · Nature Medicine · doi:10.1038/nm.3324 · Cited by 1,262 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works

Recruited brown adipose tissue as an antiobesity agent in humans

Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67803 · Cited by 957 · see citing works

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

Renier, N., Adams, E. L., Kirst, C., Wu, Z., Azevedo, R., Kohl, J., Autry, A. E., Kadiri, L., Umadevi Venkataraju, K., Zhou, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.007 · Cited by 918 · see citing works

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.021 · Cited by 878 · see citing works

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature · doi:10.1038/nature08262 · Cited by 703 · see citing works

Evidence for a role of developmental genes in the origin of obesity and body fat distribution

Gesta, S., Blüher, M., Yamamoto, Y., Norris, A. W., Berndt, J., Kralisch, S., Boucher, J., Lewis, C. R., & Kahn, C. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601752103 · Cited by 617 · see citing works

Transcriptional Control of Adipose Lipid Handling by IRF4

Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 607 · see citing works

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Chau, Y.-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2922 · Cited by 518 · see citing works

Genetic and functional characterization of clonally derived adult human brown adipocytes

Shinoda, K., Luijten, I. H. N., Hasegawa, Y., Hong, H., Sonne, S. B., Kim, M., Xue, R., Chondronikola, M., Cypess, A. M., Tseng, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3819 · Cited by 428 · see citing works

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

Lee, P., Smith, S., Linderman, J. D., Courville, A. B., Brychta, R. J., Dieckmann, W., Werner, C., Chen, K. Y., & Celi, F. S. (2014) · Diabetes · doi:10.2337/db14-0513 · Cited by 398 · see citing works

Transdifferentiation properties of adipocytes in the adipose organ

Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379 · see citing works

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

Fischer, K., Ruiz, H. H., Jhun, K., Finan, B., Oberlin, D. J., van der Heide, V., Kalinovich, A., Petrovič, N., Wolf, Y., Clemmensen, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4316 · Cited by 326 · see citing works

Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression

Jacobsson, A., Stadler, U., Glotzer, M. A., & Kozak, L. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36228-2 · Cited by 300 · see citing works

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

Xue, R., Lynes, M. D., Dreyfuss, J. M., Shamsi, F., Schulz, T. J., Zhang, H., Huang, T. L., Townsend, K. L., Li, Y., Takahashi, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3881 · Cited by 286 · see citing works

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 279 · see citing works

Fat cells directly sense temperature to activate thermogenesis

Li, Y., Wu, J., Cohen, P., Kazak, L., Khandekar, M. J., Jedrychowski, M. P., Zeng, X., Gygi, S. P., & Spiegelman, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310261110 · Cited by 245 · see citing works

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01001.x · Cited by 208 · see citing works

Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain

Winnubst, J., Bas, E., Ferreira, T. A., Wu, Z., Economo, M. N., Edson, P., Arthur, B. J., Bruns, C., Rokicki, K., Schauder, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.042 · Cited by 538 · see citing works

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

Wang, P., Loh, K. H., Wu, M., Morgan, D. A., Schneeberger, M., Yu, X., Chi, J., Kosse, C., Kim, D., Rahmouni, K., et al. (2020) · Nature · doi:10.1038/s41586-020-2527-y · Cited by 332 · see citing works

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

Hu, B., Jin, C., Zeng, X., Resch, J. M., Jedrychowski, M. P., Yang, Z., Desai, B. N., Banks, A. S., Lowell, B. B., Mathis, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2028-z · Cited by 180 · see citing works

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178 · see citing works

Microbiota-modulated CART ⁺ enteric neurons autonomously regulate blood glucose

Muller, P. A., Matheis, F., Schneeberger, M., Kerner, Z., Jové, V., & Mucida, D. (2020) · Science · doi:10.1126/science.abd6176 · Cited by 154 · see citing works

Metabolic stress drives sympathetic neuropathy within the liver

Liu, K., Yang, L., Wang, G., Liu, J., Zhao, X., Wang, Y., Li, J., & Yang, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.012 · Cited by 146 · see citing works

Obesity: A neuroimmunometabolic perspective

Larabee, C. M., Neely, O. C., & Domingos, A. I. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0283-6 · Cited by 123 · see citing works

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging

Adori, C., Daraio, T., Kuiper, R., Barde, S., Horvathova, L., Yoshitake, T., Ihnatko, R., Valladolid-Acebes, I., Vercruysse, P., Wellendorf, A. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg5733 · Cited by 105 · see citing works

The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation

Wang, Q., Sharma, V. P., Shen, H., Xiao, Y., Zhu, Q., Xiong, X., Guo, L., Jiang, L., Ohta, K., Li, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0020-9 · Cited by 71 · see citing works

Defining the molecular identity and morphology of <i>glia limitans superficialis</i> astrocytes in mouse and human

Hasel, P., Cooper, M. L., Marchildon, A. E., Rufen-Blanchette, U. A., Kim, R. D., Ma, T. C., Kang, U. J., Chao, M. V., & Liddelow, S. A. (2023) · doi:10.1101/2023.04.06.535893 · Cited by 47

Potential Roles of Phosphodiesterase 3B Knockout in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Mice

Guirguis, E., Hockman, S. C., Raghavachari, N., et al. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1304231

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 749 · see citing works

Potential Role of PDE3B in Acquisition of Brown Fat Characteristic by White Adipose Tissue in Mice

Guirguis, E., Hockman, S. C., & Manganiello, V. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.920.2

Artepillin C, a Typical Brazilian Propolis-Derived Component, Induces Brown-Like Adipocyte Formation in C3H10T1/2 Cells, Primary Inguinal White Adipose Tissue-Derived Adipocytes, and Mice

Nishikawa, S., Aoyama, H., Kamiya, M., Higuchi, J., Kato, A., Soga, M., Kawai, T., Yoshimura, K., Kumazawa, S., & Tsuda, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162512 · Cited by 62 · see citing works