The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
Open accessAbstract
Summary Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues but the functional role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of interscapular brown adipose tissue reveals that PDM have unique protein composition and cristae structure, and remain adherent to the LD in the tissue homogenate. We developed an approach to isolate PDM based on their adherence to LDs. Comparison of purified PDM to cytoplasmic mitochondria reveals that (1) PDM have increased pyruvate oxidation, electron transport, and ATP synthesis capacities. (2) PDM have reduced beta oxidation capacity and depart from LDs upon tissue activation of thermogenesis and beta oxidation. (3) PDM support LD expansion as Perilipin 5-induced recruitment of mitochondria to LDs increases ATP-dependent triglyceride synthesis. (4) PDM maintain a distinct protein composition due to uniquely low fusion-fission dynamics. We conclude that PDM represent a segregated mitochondrial population with unique structure and function that supports triglyceride synthesis.
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Cites
Brown Adipose Tissue: Function and Physiological Significance
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
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“I) suggests a mechanism by which LD association reduces mitochondrial dynamics, as we have previously shown that stationary mitochondria have markedly lower probability to undergo fusion (Twig et al., 2008, 2010).”
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Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
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“…mitochondria have unique structure, fusion dynamics, and movement Mitochondria are highly dynamic organelles that continuously undergo cycles of fusion and fission to regulate network morphology and distribute network content (Chen et al., 2005; Liesa and Shirihai, 2013; Nakada et al., 2001).”
BackgroundMitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
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Self-citationMitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
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Cited by
Dynamics and functions of lipid droplets
Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740
The cell biology of mitochondrial membrane dynamics
Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0210-7 · Cited by 1,550
Mitochondria at the crossroads of health and disease
Suomalainen, A., & Nunnari, J. (2024) · Cell · doi:10.1016/j.cell.2024.04.037 · Cited by 478
Molecular mechanisms of mitochondrial dynamics
Tábara, L.-C., Segawa, M., & Prudent, J. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00785-1 · Cited by 406
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072632 · Cited by 363
Metadata
- Authors
- Benador, I. Y., Veliova, M., Mahdaviani, K., Petcherski, A., Wikstrom, J. D., Assali, E. A., Acín-Pérez, R., Shum, M., Oliveira, M. F., Cinti, S., Sztalryd, C., Barshop, W. D., Wohlschlegel, J. A., Corkey, B. E., Liesa, M., & Shirihai, O. S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 27
- Issue
- 4
- Pages
- 869-885.e6
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2795702337
- Cited by
- 614
- References
- 49
- FWCI
- 31.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Benador, I. Y., Veliova, M., Mahdaviani, K., Petcherski, A., Wikstrom, J. D., Assali, E. A., Acín-Pérez, R., Shum, M., Oliveira, M. F., Cinti, S., Sztalryd, C., Barshop, W. D., Wohlschlegel, J. A., Corkey, B. E., Liesa, M., & Shirihai, O. S. (2018). Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metabolism. https://doi.org/10.1016/j.cmet.2018.03.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
