MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
Open accessAbstract
Mitochondria are complex organelles that house essential pathways involved in energy metabolism, ion homeostasis, signalling and apoptosis. To understand mitochondrial pathways in health and disease, it is crucial to have an accurate inventory of the organelle's protein components. In 2008, we made substantial progress toward this goal by performing in-depth mass spectrometry of mitochondria from 14 organs, epitope tagging/microscopy and Bayesian integration to assemble MitoCarta (www.broadinstitute.org/pubs/MitoCarta): an inventory of genes encoding mitochondrial-localized proteins and their expression across 14 mouse tissues. Using the same strategy we have now reconstructed this inventory separately for human and for mouse based on (i) improved gene transcript models, (ii) updated literature curation, including results from proteomic analyses of mitochondrial sub-compartments, (iii) improved homology mapping and (iv) updated versions of all seven original data sets. The updated human MitoCarta2.0 consists of 1158 human genes, including 918 genes in the original inventory as well as 240 additional genes. The updated mouse MitoCarta2.0 consists of 1158 genes, including 967 genes in the original inventory plus 191 additional genes. The improved MitoCarta 2.0 inventory provides a molecular framework for system-level analysis of mammalian mitochondria.
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According to the MitoCarta 2.0 database, 654 proteins were specific to or associated with mitochondria.
“According to the MitoCarta 2.0 database [72], 654 proteins were specific to or associated with mitochondria.”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [72]
The Introduction and “Human and Mouse MitoCarta2.0” section state that the MitoCarta2.0 inventory contains 1,158 human genes and 1,158 mouse genes encoding mitochondrial proteins, not 654. No page number is available in our copy. (LLM, conf=0.90)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredOnly 13 proteins among approximately 1200 proteins of the mitochondrial proteome are encoded by mitochondrial DNA and synthesized inside the organelle.
“However, only 13 proteins among the approximately 1200 proteins from the mitochondrial proteome, are encoded by mitochondrial DNA (mtDNA) and synthesized inside the organelle [34].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [34]
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- Authors
- Calvo, S. E., Clauser, K. R., & Mootha, V. K.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Mootha, Vamsi K.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-10-07
- Volume
- 44
- Issue
- D1
- Pages
- D1251-D1257
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC4702768
- OpenAlex
- W2180760460
- Cited by
- 1,251
- References
- 46
- Citations by year
- 2026: 40 · 2025: 54 · 2024: 56 · 2023: 70 · 2022: 115 · 2021: 186 · 2020: 218 · 2019: 177 · 2018: 161 · 2017: 108 · 2016: 64 · 2015: 2
- FWCI
- 48.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nucleic Acids Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (GM0077465)
- National Institute of General Medical Sciences (GM0077465, R01GM077465)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- mitochondrial proteins, mitochondrial proteome, Bayesian integration, epitope tagging, literature curation
- MeSH terms
- Animals, Bayes Theorem, Humans, Internet, Genomics, Mitochondrial Proteins, Databases, Protein, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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