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Cited by 290

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Open access
Curtis, Marion, Kenny, Hilary A., Ashcroft, Bradley, Mukherjee, Abir, Johnson, Alyssa, Zhang, Yilin, Helou, Ynes, Batlle, Raquel, Liu, Xiaojing, Gutierrez, Nuria, Gao, Xia, Yamada, S. Diane, Lastra, Ricardo, Montag, Anthony, Ahsan, Nagib, Locasale, Jason W., Salomon, Arthur R., Nebreda, Angel R., Lengyel, Ernst·2019·Cell Metabolism
DOI 10.1016/j.cmet.2018.08.007
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Abstract

Summary Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable isotope labeling of amino acids in cell culture (SILAC) coupled with quantitative, label-free phosphoproteomics to study the bidirectional signaling in ovarian cancer cells and human-derived, cancer-associated fibroblasts (CAFs) after co-culture. In cancer cells, the interaction with CAFs supported glycogenolysis under normoxic conditions and induced phosphorylation and activation of phosphoglucomutase 1 (PGM1), an enzyme involved in glycogen metabolism. Glycogen was funneled into glycolysis, leading to increased proliferation, invasion, and metastasis of cancer cells co-cultured with human CAFs. Glycogen mobilization in cancer cells was dependent on p38α MAPK activation in CAFs. In vivo, deletion of p38α in CAFs and glycogen phosphorylase inhibition in cancer cells reduced metastasis, suggesting that glycogen is an energy source used by cancer cells to facilitate metastatic tumor growth.

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Metadata

Authors
Curtis, M., Kenny, H. A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N., Gao, X., Yamada, S. D., Lastra, R., Montag, A., Ahsan, N., Locasale, J. W., Salomon, A. R., Nebreda, A. R., & Lengyel, E.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2019-01
Volume
29
Issue
1
Pages
141-155.e9
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2018.08.007
OpenAlex
W2888786292
Cited by
290
References
9
FWCI
7.92
Type
journal article
Language
en
Open access
bronze
Licence
Funders
  • Cancer Research Foundation Fletcher Scholars
  • National Cancer Institute (R01 CA169604, R01 CA193256, R00CA168997, R21CA201963)
  • European Commission (294665)
  • Cancer Center (P30CA014599)
  • University of Chicago

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CoChat. (2026). Citation check: Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. https://app.cochat.ai/papers/10.1016/j.cmet.2018.08.007
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Curtis, M., Kenny, H. A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N., Gao, X., Yamada, S. D., Lastra, R., Montag, A., Ahsan, N., Locasale, J. W., Salomon, A. R., Nebreda, A. R., & Lengyel, E. (2019). Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metabolism. https://doi.org/10.1016/j.cmet.2018.08.007

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.