The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
Open accessAbstract
Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that methionine is rapidly taken up by activated T cells and serves as the major substrate for biosynthesis of the universal methyl donor S-adenosyl-L-methionine (SAM). Methionine was required to maintain intracellular SAM pools in T cells. Methionine restriction reduced histone H3K4 methylation (H3K4me3) at the promoter regions of key genes involved in Th17 cell proliferation and cytokine production. Applied to the mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis), dietary methionine restriction reduced the expansion of pathogenic Th17 cells in vivo, leading to reduced T cell-mediated neuroinflammation and disease onset. Our data identify methionine as a key nutritional factor shaping Th cell proliferation and function in part through regulation of histone methylation.
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Overview of the immune response
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Self-citationAmino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
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Metadata
- Authors
- Roy, D. G., Chen, J., Mamane, V., Ma, E. H., Muhire, B. M., Sheldon, R. D., Shorstova, T., Koning, R., Johnson, R. M., Esaulova, E., Williams, K. S., Hayes, S., Steadman, M., Samborska, B., Swain, A., Daigneault, A., Chubukov, V., Roddy, T. P., Foulkes, W., Pospisilik, J. A., Bourgeois-Daigneault, M.-C., Artyomov, M. N., Witcher, M., Krawczyk, C. M., Larochelle, C., & Jones, R. G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 31
- Issue
- 2
- Pages
- 250-266.e9
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W3004655368
- Cited by
- 348
- References
- 60
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Roy, D. G., Chen, J., Mamane, V., Ma, E. H., Muhire, B. M., Sheldon, R. D., Shorstova, T., Koning, R., Johnson, R. M., Esaulova, E., Williams, K. S., Hayes, S., Steadman, M., Samborska, B., Swain, A., Daigneault, A., Chubukov, V., Roddy, T. P., Foulkes, W., . . . Jones, R. G. (2020). Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. Cell Metabolism. https://doi.org/10.1016/j.cmet.2020.01.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
