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Why does obesity cause diabetes?
Open accessAbstract
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.
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“It has also been shown to reduce both quality of life and life expectancy (2).”
From The Benefits of Exercise Training in Combination With Weight Loss Therapies (2025) · cites this paper as [2]
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Metadata
- Authors
- Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E.
- Affiliations
- Washington University in St. Louis (US)
- Istituto di Fisiologia Clinica (IT)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Klein, Samuel
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 34
- Issue
- 1
- Pages
- 11-20
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC8740746
- OpenAlex
- W4206513048
- Cited by
- 939
- References
- 112
- Citations by year
- 2026: 196 · 2025: 329 · 2024: 249 · 2023: 112 · 2022: 51
- FWCI
- 29.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Sigrid Juséliuksen Säätiö
- Inventiva Pharma
- National Institutes of Health (R01-DK099110, DK20579, RC2-DK118620, UL1TR002345, DK56341, R01-DK55758)
- Academy of Finland
- Eli Lilly and Company
- Gilead Sciences
- Janssen Pharmaceuticals
- Merck
- Novo Nordisk
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, type 2 diabetes, body mass index, beta-cell dysfunction, adipose tissue, insulin resistance, weight loss, diabetes pathogenesis
- MeSH terms
- Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adiposity
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