Cited by 940Adipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

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Why does obesity cause diabetes?

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Klein, Samuel, Gastaldelli, Amalia, Yki-Järvinen, Hannele, Scherer, Philipp E.·2022·Cell Metabolism

DOI 10.1016/j.cmet.2021.12.012PMC PMC8740746

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Abstract

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.

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Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
Sjöström, L., Lindroos, A.-K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjöström, C. D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035622 · Cited by 4,457
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028

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Xie, Y., Tang, Y., Yang, J., Atta, M., Wang, N., & Qin, H. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70038 · Cited by 2
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Bibi, S., Naeem, M. T., Schipf, S., Bahls, M., Dörr, M., Friedrich, N., Nauck, M. A., Bülow, R., Völzke, H., Markus, M. R. P., et al. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70005 · Cited by 2
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Rao, J., Ding, C., Shi, Y., Zhou, W., Yu, C., Wang, T., Zhu, L., Huang, X. B., Bao, H., & Cheng, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1467886 · Cited by 3
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Authors: Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E.
Affiliations: Washington University in St. Louis (US)
Istituto di Fisiologia Clinica (IT)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Klein, Samuel
ORCID: Klein, Samuel
Gastaldelli, Amalia
Scherer, Philipp E.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2022-01
Volume: 34
Issue: 1
Pages: 11-20
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2021.12.012
PMC: PMC8740746
OpenAlex: W4206513048
Cited by: 939
References: 112
Citations by year: 2026: 196 · 2025: 329 · 2024: 249 · 2023: 112 · 2022: 51
FWCI: 29.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Sigrid Juséliuksen Säätiö
Inventiva Pharma
National Institutes of Health (R01-DK099110, DK20579, RC2-DK118620, UL1TR002345, DK56341, R01-DK55758)
Academy of Finland
Eli Lilly and Company
Gilead Sciences
Janssen Pharmaceuticals
Merck
Novo Nordisk
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, type 2 diabetes, body mass index, beta-cell dysfunction, adipose tissue, insulin resistance, weight loss, diabetes pathogenesis
MeSH terms: Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adiposity

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