Cited by 940Adipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

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Why does obesity cause diabetes?

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Klein, Samuel, Gastaldelli, Amalia, Yki-Järvinen, Hannele, Scherer, Philipp E.·2022·Cell Metabolism

DOI 10.1016/j.cmet.2021.12.012PMC PMC8740746

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Abstract

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.

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Authors: Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E.
Affiliations: Washington University in St. Louis (US)
Istituto di Fisiologia Clinica (IT)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Klein, Samuel
ORCID: Klein, Samuel
Gastaldelli, Amalia
Scherer, Philipp E.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2022-01
Volume: 34
Issue: 1
Pages: 11-20
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2021.12.012
PMC: PMC8740746
OpenAlex: W4206513048
Cited by: 939
References: 112
Citations by year: 2026: 196 · 2025: 329 · 2024: 249 · 2023: 112 · 2022: 51
FWCI: 29.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Sigrid Juséliuksen Säätiö
Inventiva Pharma
National Institutes of Health (R01-DK099110, DK20579, RC2-DK118620, UL1TR002345, DK56341, R01-DK55758)
Academy of Finland
Eli Lilly and Company
Gilead Sciences
Janssen Pharmaceuticals
Merck
Novo Nordisk
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, type 2 diabetes, body mass index, beta-cell dysfunction, adipose tissue, insulin resistance, weight loss, diabetes pathogenesis
MeSH terms: Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adiposity

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