The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The REDCap consortium: building an international community of software platform partners
Harris, P. A., Taylor, R., Minor, B. L., Elliott, V., Fernandez, M., O'Neal, L., McLeod, L., Delacqua, G., Delacqua, F., Kirby, J., et al. (2019) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2019.103208 · Cited by 24,013
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation
Blondin, D. P., Nielsen, S., Kuipers, E. N., Severinsen, M. C., Jensen, V. H., Miard, S., Jespersen, N. Z., Kooijman, S., Boon, M. R., Fortin, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.07.005 · Cited by 331
Self-citationPostprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis
U Din, M., Saari, T., Raiko, J., Kudomi, N., Maurer, S. F., Lahesmaa, M., Fromme, T., Amri, E.-Z., Klingenspor, M., Solin, O., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.020 · Cited by 196
Self-citation
Research works printed but not linked: 65
- Carpentier, 2023, Brown adipose tissue-a translational perspective, Endocr. Rev., 44, 143, 10.1210/endrev/bnac015 · DOI · Paper page
- Cypess, 2009, Identification and importance of brown adipose tissue in adult humans, N. Engl. J. Med., 360, 1509, 10.1056/NEJMoa0810780 · DOI · Paper page
- van Marken Lichtenbelt, 2009, Cold-activated brown adipose tissue in healthy men, N. Engl. J. Med., 360, 1500, 10.1056/NEJMoa0808718 · DOI · Paper page
- Virtanen, 2009, Functional brown adipose tissue in healthy adults, N. Engl. J. Med., 360, 1518, 10.1056/NEJMoa0808949 · DOI · Paper page
- Becher, 2021, Brown adipose tissue is associated with cardiometabolic health, Nat. Med., 27, 58, 10.1038/s41591-020-1126-7 · DOI · Paper page
- Cannon, 2004, Brown adipose tissue: function and physiological significance, Physiol. Rev., 84, 277, 10.1152/physrev.00015.2003 · DOI · Paper page
- Nikami, 1996, Expression of beta3-adrenoceptor and stimulation of glucose transport by beta3-agonists in brown adipocyte primary culture, J. Biochem., 119, 120, 10.1093/oxfordjournals.jbchem.a021196 · doi:10.1093/oxfordjournals.jbchem.a021196
- Ghorbani, 1997, Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats, Int. J. Obes. Relat. Metab. Disord., 21, 465, 10.1038/sj.ijo.0800432 · DOI · Paper page
- Cypess, 2015, Activation of human brown adipose tissue by a β3-adrenergic receptor agonist, Cell Metab., 21, 33, 10.1016/j.cmet.2014.12.009 · DOI · Paper page
- O'Mara, 2020, Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity, J. Clin. Investig., 130, 2209, 10.1172/JCI131126 · DOI · Paper page
- Nahon, 2020, The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men, Diabetes Obes. Metab., 22, 2032, 10.1111/dom.14120 · DOI
- Deng, 1996, Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues, Br. J. Pharmacol., 118, 929, 10.1111/j.1476-5381.1996.tb15488.x · DOI
- Ishida, 2024, Genetic evidence for involvement of beta2-adrenergic receptor in brown adipose tissue thermogenesis in humans, Int. J. Obes., 48, 1110, 10.1038/s41366-024-01522-6 · DOI
- Lee, 2013, Formoterol, a highly beta2-selective agonist, increases energy expenditure and fat utilisation in men, Int. J. Obes., 37, 593, 10.1038/ijo.2012.90 · DOI
- Onslev, 2017, Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men, Eur. J. Appl. Physiol., 117, 1907, 10.1007/s00421-017-3679-9 · DOI
- Loeliger, 2021, Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men, Am. J. Physiol., Endocrinol. Metab., 320, E93, 10.1152/ajpendo.00237.2020 · DOI
- Maushart, 2021, Free thyroxine levels are associated with cold induced thermogenesis in healthy euthyroid individuals, Front. Endocrinol., 12, 10.3389/fendo.2021.666595 · DOI
- Acosta, 2018, Physiological responses to acute cold exposure in young lean men, PLoS One, 13
- van der Lans, 2016, Supraclavicular skin temperature and BAT activity in lean healthy adults, J. Physiol. Sci., 66, 77, 10.1007/s12576-015-0398-z · DOI
- Chen, 2016, Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): recommendations for standardized FDG-PET/CT experiments in humans, Cell Metab., 24, 210, 10.1016/j.cmet.2016.07.014 · DOI · Paper page
- Weir, 2018, Substantial metabolic activity of human brown adipose tissue during warm conditions and cold-induced lipolysis of local triglycerides, Cell Metab., 27, 1348, 10.1016/j.cmet.2018.04.020 · DOI · Paper page
- Yoneshiro, 2019, BCAA catabolism in brown fat controls energy homeostasis through SLC25A44, Nature, 572, 614, 10.1038/s41586-019-1503-x · DOI · Paper page
- Chondronikola, 2016, Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans, Cell Metab., 23, 1200, 10.1016/j.cmet.2016.04.029 · DOI · Paper page
- Ouellet, 2012, Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans, J. Clin. Investig., 122, 545, 10.1172/JCI60433 · DOI · Paper page
- Maushart, 2023, Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men, EBiomedicine, 96, 10.1016/j.ebiom.2023.104771 · DOI
- Wakabayashi, 2020, Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans, Eur. J. Appl. Physiol., 120, 2737, 10.1007/s00421-020-04496-1 · doi:10.1007/s00421-020-04496-1
- Claessens-van Ooijen, 2006, Heat production and body temperature during cooling and rewarming in overweight and lean men, Obesity, 14, 1914, 10.1038/oby.2006.223 · DOI
- Kellogg, 2006, In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges, J. Appl. Physiol., 100, 1709, 10.1152/japplphysiol.01071.2005 · DOI · Paper page
- Morrison, 2008, Central control of thermogenesis in mammals, Exp. Physiol., 93, 773, 10.1113/expphysiol.2007.041848 · DOI · Paper page
- Straat, 2023, Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue, Cell Rep. Med., 4
- Blondin, 2017, Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans, Cell Metab., 25, 438, 10.1016/j.cmet.2016.12.005 · DOI · Paper page
- Park, 2023, Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis, Nat. Metab., 5, 1204, 10.1038/s42255-023-00825-8 · DOI
- Bornstein, 2023, Comprehensive quantification of metabolic flux during acute cold stress in mice, Cell Metab., 35, 2077, 10.1016/j.cmet.2023.09.002 · DOI
- Haffner, 1992, Metabolic effects of beta 2-agonists, J. Clin. Pharm. Ther., 17, 155, 10.1111/j.1365-2710.1992.tb01285.x · DOI
- Taylor, 1992, Interaction between corticosteroid and beta-agonist drugs. Biochemical and cardiovascular effects in normal subjects, Chest, 102, 519, 10.1378/chest.102.2.519 · DOI
- Schiffelers, 2001, beta(1)- and beta(2)-adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men, J. Clin. Endocrinol. Metab., 86, 2191
- Baker, 2010, The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors, Br. J. Pharmacol., 160, 1048, 10.1111/j.1476-5381.2010.00754.x · DOI · Paper page
- Bolker, 2017, Animal models in translational research: Rosetta Stone or stumbling block?, BioEssays, 39, 10.1002/bies.201700089 · DOI
- Luca, 2024, Lesson on obesity and anatomy of adipose tissue: new models of study in the era of clinical and translational research, J. Transl. Med., 22, 10.1186/s12967-024-05547-3 · DOI
- Min, 2019, Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells, Proc. Natl. Acad. Sci. USA, 116, 17970, 10.1073/pnas.1906512116 · DOI
- Shinoda, 2015, Genetic and functional characterization of clonally derived adult human brown adipocytes, Nat. Med., 21, 389, 10.1038/nm.3819 · DOI · Paper page
- Wang, 2024, Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes, Cell Metab., 36, 2130, 10.1016/j.cmet.2024.07.005 · DOI
- Wu, 2012, Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human, Cell, 150, 366, 10.1016/j.cell.2012.05.016 · DOI · Paper page
- Talamonti, 2024, The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis, Mol. Metab., 85, 10.1016/j.molmet.2024.101931 · DOI
- Brady, 2021, Effect of propranolol on 18F-fluorodeoxyglucose uptake in brown adipose tissue in children and young adults with neoplastic diseases, Mol. Imaging Biol., 23, 260, 10.1007/s11307-020-01547-z · DOI
- Söderlund, 2007, Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol, Eur. J. Nucl. Med. Mol. Imaging, 34, 1018, 10.1007/s00259-006-0318-9 · DOI · Paper page
- Vosselman, 2012, Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans, Diabetes, 61, 3106, 10.2337/db12-0288 · DOI · Paper page
- Ng, 1993, Age and gender influence muscle sympathetic nerve activity at rest in healthy humans, Hypertension, 21, 498, 10.1161/01.HYP.21.4.498 · DOI · Paper page
- Gnad, 2014, Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors, Nature, 516, 395, 10.1038/nature13816 · DOI · Paper page
- Lahesmaa, 2019, Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT, Eur. J. Nucl. Med. Mol. Imaging, 46, 743, 10.1007/s00259-018-4120-2 · DOI
- Onslev, 2022, Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise, J. Clin. Endocrinol. Metab., 107, e1193, 10.1210/clinem/dgab752 · DOI
- Blaak, 1994, Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men, Am. J. Physiol., 267, E306
- Hoeks, 2003, Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans, Am. J. Physiol., Endocrinol. Metab., 285, E775, 10.1152/ajpendo.00175.2003 · DOI
- Ikeda, 2017, UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis, Nat. Med., 23, 1454, 10.1038/nm.4429 · DOI · Paper page
- Rahbani, 2021, Creatine kinase B controls futile creatine cycling in thermogenic fat, Nature, 590, 480, 10.1038/s41586-021-03221-y · DOI · Paper page
- Rahbani, 2024, Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB, Cell Metab., 36, 526, 10.1016/j.cmet.2024.01.001 · DOI
- Auger, 2025, Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue, Cell Metab., 37, 1311, 10.1016/j.cmet.2025.03.009 · DOI
- Wasserthal, 2023, TotalSegmentator: robust segmentation of 104 anatomic structures in CT images, Radiol. Artif. Intell., 5, 10.1148/ryai.230024 · DOI · Paper page
- Fedorov, 2012, 3D Slicer as an image computing platform for the Quantitative Imaging Network, Magn. Reson. Imaging, 30, 1323, 10.1016/j.mri.2012.05.001 · DOI · Paper page
- Harris, 2009, Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support, J. Biomed. Inform., 42, 377, 10.1016/j.jbi.2008.08.010 · DOI · Paper page
- Weir, 1949, New methods for calculating metabolic rate with special reference to protein metabolism, J. Physiol., 109, 1, 10.1113/jphysiol.1949.sp004363 · DOI · Paper page
- Warnke, 1992, The pharmacokinetics of the beta 2-adrenoceptor agonist fenoterol in healthy women, Eur. J. Clin. Pharmacol., 43, 663, 10.1007/BF02284970 · doi:10.1007/bf02284970
- Hochhaus, 1992, Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol, Int. J. Clin. Pharmacol. Ther. Toxicol., 30, 342
- Ter Voert, 2020, Low-dose 18F-FDG TOF-PET/MR for accurate quantification of brown adipose tissue in healthy volunteers, EJNMMI Res., 10, 10.1186/s13550-020-0592-8 · DOI
- Schindelin, 2012, Fiji: an open-source platform for biological-image analysis, Nat. Methods, 9, 676, 10.1038/nmeth.2019 · DOI · Paper page
Metadata
- Authors
- Füchtbauer, L. M., Senn, J. R., Baumann, C. S., Isenrich, A. L., Gaynor, T. L., Schläfli, R., Sharma, A. K., Horvath, C., Maushart, C. I., Ghosh, A., Virtanen, K. A., Fromme, T., Chirindel, A., Wild, D., Nielsen, S., Wolfrum, C., & Betz, M. J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2026-09
- Volume
- 38
- Issue
- 9
- Pages
- 1802-1814.e4
- ISSN
- 1550-4131
- Cited by
- 3
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by/4.0/ (vor)
- Funders
- TrygFonden (101390, 125132, 177225, 20045)
- Novartis Foundation for Medical-Biological Research (24A022)
- Sigrid Juséliuksen Säätiö
- Research Council of Finland (335446, 265204, 259926, 314456, 292839)
- European Commission
- Diabetestutkimussäätiö
- Suomen Lääketieteen Säätiö
- Novo Nordisk Fonden (NNF17SA0031406, NNF20OC0061400)
- European Research Council (EUFP7 project 278373 ; DIABAT)
- Swiss National Science Foundation (32003B_201065)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. https://app.cochat.ai/papers/10.1016/j.cmet.2026.07.012
- The paper
- Füchtbauer, L. M., Senn, J. R., Baumann, C. S., Isenrich, A. L., Gaynor, T. L., Schläfli, R., Sharma, A. K., Horvath, C., Maushart, C. I., Ghosh, A., Virtanen, K. A., Fromme, T., Chirindel, A., Wild, D., Nielsen, S., Wolfrum, C., & Betz, M. J. (2026). Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. Cell Metabolism. https://doi.org/10.1016/j.cmet.2026.07.012
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.