Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 3

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue

Füchtbauer, Laila Maria, Senn, Jaël Rut, Baumann, Carole Stéphanie, Isenrich, Anninja Lea, Gaynor, Taylah Lea, Schläfli, Rahel, Sharma, Anand Kumar, Horvath, Carla, Maushart, Claudia Irene, Ghosh, Adhideb, Virtanen, Kirsi A., Fromme, Tobias, Chirindel, Alin, Wild, Damian, Nielsen, Søren, Wolfrum, Christian, Betz, Matthias Johannes·2026·Cell Metabolism

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2026.07.012

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 65

  1. Carpentier, 2023, Brown adipose tissue-a translational perspective, Endocr. Rev., 44, 143, 10.1210/endrev/bnac015 · DOI · Paper page
  2. Cypess, 2009, Identification and importance of brown adipose tissue in adult humans, N. Engl. J. Med., 360, 1509, 10.1056/NEJMoa0810780 · DOI · Paper page
  3. van Marken Lichtenbelt, 2009, Cold-activated brown adipose tissue in healthy men, N. Engl. J. Med., 360, 1500, 10.1056/NEJMoa0808718 · DOI · Paper page
  4. Virtanen, 2009, Functional brown adipose tissue in healthy adults, N. Engl. J. Med., 360, 1518, 10.1056/NEJMoa0808949 · DOI · Paper page
  5. Becher, 2021, Brown adipose tissue is associated with cardiometabolic health, Nat. Med., 27, 58, 10.1038/s41591-020-1126-7 · DOI · Paper page
  6. Cannon, 2004, Brown adipose tissue: function and physiological significance, Physiol. Rev., 84, 277, 10.1152/physrev.00015.2003 · DOI · Paper page
  7. Nikami, 1996, Expression of beta3-adrenoceptor and stimulation of glucose transport by beta3-agonists in brown adipocyte primary culture, J. Biochem., 119, 120, 10.1093/oxfordjournals.jbchem.a021196 · doi:10.1093/oxfordjournals.jbchem.a021196
  8. Ghorbani, 1997, Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats, Int. J. Obes. Relat. Metab. Disord., 21, 465, 10.1038/sj.ijo.0800432 · DOI · Paper page
  9. Cypess, 2015, Activation of human brown adipose tissue by a β3-adrenergic receptor agonist, Cell Metab., 21, 33, 10.1016/j.cmet.2014.12.009 · DOI · Paper page
  10. O'Mara, 2020, Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity, J. Clin. Investig., 130, 2209, 10.1172/JCI131126 · DOI · Paper page
  11. Nahon, 2020, The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men, Diabetes Obes. Metab., 22, 2032, 10.1111/dom.14120 · DOI
  12. Deng, 1996, Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues, Br. J. Pharmacol., 118, 929, 10.1111/j.1476-5381.1996.tb15488.x · DOI
  13. Ishida, 2024, Genetic evidence for involvement of beta2-adrenergic receptor in brown adipose tissue thermogenesis in humans, Int. J. Obes., 48, 1110, 10.1038/s41366-024-01522-6 · DOI
  14. Lee, 2013, Formoterol, a highly beta2-selective agonist, increases energy expenditure and fat utilisation in men, Int. J. Obes., 37, 593, 10.1038/ijo.2012.90 · DOI
  15. Onslev, 2017, Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men, Eur. J. Appl. Physiol., 117, 1907, 10.1007/s00421-017-3679-9 · DOI
  16. Loeliger, 2021, Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men, Am. J. Physiol., Endocrinol. Metab., 320, E93, 10.1152/ajpendo.00237.2020 · DOI
  17. Maushart, 2021, Free thyroxine levels are associated with cold induced thermogenesis in healthy euthyroid individuals, Front. Endocrinol., 12, 10.3389/fendo.2021.666595 · DOI
  18. Acosta, 2018, Physiological responses to acute cold exposure in young lean men, PLoS One, 13
  19. van der Lans, 2016, Supraclavicular skin temperature and BAT activity in lean healthy adults, J. Physiol. Sci., 66, 77, 10.1007/s12576-015-0398-z · DOI
  20. Chen, 2016, Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): recommendations for standardized FDG-PET/CT experiments in humans, Cell Metab., 24, 210, 10.1016/j.cmet.2016.07.014 · DOI · Paper page
  21. Weir, 2018, Substantial metabolic activity of human brown adipose tissue during warm conditions and cold-induced lipolysis of local triglycerides, Cell Metab., 27, 1348, 10.1016/j.cmet.2018.04.020 · DOI · Paper page
  22. Yoneshiro, 2019, BCAA catabolism in brown fat controls energy homeostasis through SLC25A44, Nature, 572, 614, 10.1038/s41586-019-1503-x · DOI · Paper page
  23. Chondronikola, 2016, Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans, Cell Metab., 23, 1200, 10.1016/j.cmet.2016.04.029 · DOI · Paper page
  24. Ouellet, 2012, Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans, J. Clin. Investig., 122, 545, 10.1172/JCI60433 · DOI · Paper page
  25. Maushart, 2023, Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men, EBiomedicine, 96, 10.1016/j.ebiom.2023.104771 · DOI
  26. Wakabayashi, 2020, Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans, Eur. J. Appl. Physiol., 120, 2737, 10.1007/s00421-020-04496-1 · doi:10.1007/s00421-020-04496-1
  27. Claessens-van Ooijen, 2006, Heat production and body temperature during cooling and rewarming in overweight and lean men, Obesity, 14, 1914, 10.1038/oby.2006.223 · DOI
  28. Kellogg, 2006, In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges, J. Appl. Physiol., 100, 1709, 10.1152/japplphysiol.01071.2005 · DOI · Paper page
  29. Morrison, 2008, Central control of thermogenesis in mammals, Exp. Physiol., 93, 773, 10.1113/expphysiol.2007.041848 · DOI · Paper page
  30. Straat, 2023, Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue, Cell Rep. Med., 4
  31. Blondin, 2017, Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans, Cell Metab., 25, 438, 10.1016/j.cmet.2016.12.005 · DOI · Paper page
  32. Park, 2023, Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis, Nat. Metab., 5, 1204, 10.1038/s42255-023-00825-8 · DOI
  33. Bornstein, 2023, Comprehensive quantification of metabolic flux during acute cold stress in mice, Cell Metab., 35, 2077, 10.1016/j.cmet.2023.09.002 · DOI
  34. Haffner, 1992, Metabolic effects of beta 2-agonists, J. Clin. Pharm. Ther., 17, 155, 10.1111/j.1365-2710.1992.tb01285.x · DOI
  35. Taylor, 1992, Interaction between corticosteroid and beta-agonist drugs. Biochemical and cardiovascular effects in normal subjects, Chest, 102, 519, 10.1378/chest.102.2.519 · DOI
  36. Schiffelers, 2001, beta(1)- and beta(2)-adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men, J. Clin. Endocrinol. Metab., 86, 2191
  37. Baker, 2010, The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors, Br. J. Pharmacol., 160, 1048, 10.1111/j.1476-5381.2010.00754.x · DOI · Paper page
  38. Bolker, 2017, Animal models in translational research: Rosetta Stone or stumbling block?, BioEssays, 39, 10.1002/bies.201700089 · DOI
  39. Luca, 2024, Lesson on obesity and anatomy of adipose tissue: new models of study in the era of clinical and translational research, J. Transl. Med., 22, 10.1186/s12967-024-05547-3 · DOI
  40. Min, 2019, Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells, Proc. Natl. Acad. Sci. USA, 116, 17970, 10.1073/pnas.1906512116 · DOI
  41. Shinoda, 2015, Genetic and functional characterization of clonally derived adult human brown adipocytes, Nat. Med., 21, 389, 10.1038/nm.3819 · DOI · Paper page
  42. Wang, 2024, Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes, Cell Metab., 36, 2130, 10.1016/j.cmet.2024.07.005 · DOI
  43. Wu, 2012, Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human, Cell, 150, 366, 10.1016/j.cell.2012.05.016 · DOI · Paper page
  44. Talamonti, 2024, The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis, Mol. Metab., 85, 10.1016/j.molmet.2024.101931 · DOI
  45. Brady, 2021, Effect of propranolol on 18F-fluorodeoxyglucose uptake in brown adipose tissue in children and young adults with neoplastic diseases, Mol. Imaging Biol., 23, 260, 10.1007/s11307-020-01547-z · DOI
  46. Söderlund, 2007, Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol, Eur. J. Nucl. Med. Mol. Imaging, 34, 1018, 10.1007/s00259-006-0318-9 · DOI · Paper page
  47. Vosselman, 2012, Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans, Diabetes, 61, 3106, 10.2337/db12-0288 · DOI · Paper page
  48. Ng, 1993, Age and gender influence muscle sympathetic nerve activity at rest in healthy humans, Hypertension, 21, 498, 10.1161/01.HYP.21.4.498 · DOI · Paper page
  49. Gnad, 2014, Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors, Nature, 516, 395, 10.1038/nature13816 · DOI · Paper page
  50. Lahesmaa, 2019, Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT, Eur. J. Nucl. Med. Mol. Imaging, 46, 743, 10.1007/s00259-018-4120-2 · DOI
  51. Onslev, 2022, Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise, J. Clin. Endocrinol. Metab., 107, e1193, 10.1210/clinem/dgab752 · DOI
  52. Blaak, 1994, Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men, Am. J. Physiol., 267, E306
  53. Hoeks, 2003, Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans, Am. J. Physiol., Endocrinol. Metab., 285, E775, 10.1152/ajpendo.00175.2003 · DOI
  54. Ikeda, 2017, UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis, Nat. Med., 23, 1454, 10.1038/nm.4429 · DOI · Paper page
  55. Rahbani, 2021, Creatine kinase B controls futile creatine cycling in thermogenic fat, Nature, 590, 480, 10.1038/s41586-021-03221-y · DOI · Paper page
  56. Rahbani, 2024, Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB, Cell Metab., 36, 526, 10.1016/j.cmet.2024.01.001 · DOI
  57. Auger, 2025, Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue, Cell Metab., 37, 1311, 10.1016/j.cmet.2025.03.009 · DOI
  58. Wasserthal, 2023, TotalSegmentator: robust segmentation of 104 anatomic structures in CT images, Radiol. Artif. Intell., 5, 10.1148/ryai.230024 · DOI · Paper page
  59. Fedorov, 2012, 3D Slicer as an image computing platform for the Quantitative Imaging Network, Magn. Reson. Imaging, 30, 1323, 10.1016/j.mri.2012.05.001 · DOI · Paper page
  60. Harris, 2009, Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support, J. Biomed. Inform., 42, 377, 10.1016/j.jbi.2008.08.010 · DOI · Paper page
  61. Weir, 1949, New methods for calculating metabolic rate with special reference to protein metabolism, J. Physiol., 109, 1, 10.1113/jphysiol.1949.sp004363 · DOI · Paper page
  62. Warnke, 1992, The pharmacokinetics of the beta 2-adrenoceptor agonist fenoterol in healthy women, Eur. J. Clin. Pharmacol., 43, 663, 10.1007/BF02284970 · doi:10.1007/bf02284970
  63. Hochhaus, 1992, Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol, Int. J. Clin. Pharmacol. Ther. Toxicol., 30, 342
  64. Ter Voert, 2020, Low-dose 18F-FDG TOF-PET/MR for accurate quantification of brown adipose tissue in healthy volunteers, EJNMMI Res., 10, 10.1186/s13550-020-0592-8 · DOI
  65. Schindelin, 2012, Fiji: an open-source platform for biological-image analysis, Nat. Methods, 9, 676, 10.1038/nmeth.2019 · DOI · Paper page

Metadata

Authors
Füchtbauer, L. M., Senn, J. R., Baumann, C. S., Isenrich, A. L., Gaynor, T. L., Schläfli, R., Sharma, A. K., Horvath, C., Maushart, C. I., Ghosh, A., Virtanen, K. A., Fromme, T., Chirindel, A., Wild, D., Nielsen, S., Wolfrum, C., & Betz, M. J.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2026-09
Volume
38
Issue
9
Pages
1802-1814.e4
ISSN
1550-4131
Cited by
3
References
3
Language
en
Licence
Funders
  • TrygFonden (101390, 125132, 177225, 20045)
  • Novartis Foundation for Medical-Biological Research (24A022)
  • Sigrid Juséliuksen Säätiö
  • Research Council of Finland (335446, 265204, 259926, 314456, 292839)
  • European Commission
  • Diabetestutkimussäätiö
  • Suomen Lääketieteen Säätiö
  • Novo Nordisk Fonden (NNF17SA0031406, NNF20OC0061400)
  • European Research Council (EUFP7 project 278373 ; DIABAT)
  • Swiss National Science Foundation (32003B_201065)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. https://app.cochat.ai/papers/10.1016/j.cmet.2026.07.012
The paper
Füchtbauer, L. M., Senn, J. R., Baumann, C. S., Isenrich, A. L., Gaynor, T. L., Schläfli, R., Sharma, A. K., Horvath, C., Maushart, C. I., Ghosh, A., Virtanen, K. A., Fromme, T., Chirindel, A., Wild, D., Nielsen, S., Wolfrum, C., & Betz, M. J. (2026). Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. Cell Metabolism. https://doi.org/10.1016/j.cmet.2026.07.012

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.