The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Parasitic helminth infections and the control of human allergic and autoimmune disorders
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The host response to helminth infections is associated with allergic phenomena that are a consequence of killing or an attempt to kill or expel these parasites.26”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diet, metabolites, and “western-lifestyle” inflammatory diseases
Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.014 · Cited by 879
McSorley, H. J., Blair, N. F., Smith, K. A., McKenzie, A. N. J., & Maizels, R. M. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.123 · Cited by 163
Self-citationPlatts-Mills, T. A. E., Woodfolk, J. A., Erwin, E. A., & Aalberse, R. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-003-0149-8 · Cited by 72
Research works printed but not linked: 72
- Maizels, 2008, T-cell regulation in helminth parasite infections: implications for inflammatory diseases, Chem Immunol Allergy, 94, 112, 10.1159/000154944 · DOI
- Asher, 2006, Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys, Lancet, 368, 733, 10.1016/S0140-6736(06)69283-0 · DOI · Paper page
- Gale, 2002, The rise of childhood type 1 diabetes in the 20th century, Diabetes, 51, 3353, 10.2337/diabetes.51.12.3353 · DOI
- Economou, 2008, New global map of Crohn's disease: genetic, environmental, and socioeconomic correlations, Inflamm Bowel Dis, 14, 709, 10.1002/ibd.20352 · DOI
- McKay, 2009, The therapeutic helminth?, Trends Parasitol, 25, 109, 10.1016/j.pt.2008.11.008 · DOI
- McSorley, 2012, Helminth infections and host immune regulation, Clin Micro Rev, 25, 585, 10.1128/CMR.05040-11 · DOI · Paper page
- Hotez, 2008, Helminth infections: the great neglected tropical diseases, J Clin Invest, 118, 1311, 10.1172/JCI34261 · DOI
- King, 2015, It's time to dispel the myth of ‘asymptomatic’ schistosomiasis, PLoS Negl Trop Dis, 9, e0003504, 10.1371/journal.pntd.0003504 · DOI
- Maizels, 2003, Regulation of the immune response by helminth parasites: cellular and molecular mechanisms, Nat Rev Immunol, 3, 733, 10.1038/nri1183 · DOI
- Colley, 1986, Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease, Am J Trop Med Hyg, 35, 793, 10.4269/ajtmh.1986.35.793 · DOI
- Sartono, 1995, Elevated cellular responses and interferon-γ release after long-term diethylcarbamazine treatment of patients with human lymphatic filariasis, J Infect Dis, 171, 1683, 10.1093/infdis/171.6.1683 · DOI
- Mahanty, 1996, High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis, J Infect Dis, 173, 769, 10.1093/infdis/173.3.769 · DOI · Paper page
- Babu, 2009, Filarial lymphedema is characterized by antigen-specific Th1 and Th17 proinflammatory responses and a lack of regulatory T cells, PLoS Negl Trop Dis, 3, e420, 10.1371/journal.pntd.0000420 · DOI
- Mbow, 2013, T-helper 17 cells are associated with pathology in human schistosomiasis, J Infect Dis, 207, 186, 10.1093/infdis/jis654 · DOI
- Kurniawan, 1993, Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis, J Immunol, 150, 3941, 10.4049/jimmunol.150.9.3941 · DOI
- Jeannin, 1998, IgE versus IgG4 production can be differentially regulated by IL-10, J Immunol, 160, 3555, 10.4049/jimmunol.160.7.3555 · DOI
- Watanabe, 2007, T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment, Am J Trop Med Hyg, 77, 676, 10.4269/ajtmh.2007.77.676 · DOI
- Wammes, 2012, Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics, PLoS Negl Trop Dis, 6, e1655, 10.1371/journal.pntd.0001655 · DOI
- Metenou, 2013, Regulatory T cell subsets in filarial infection and their function, Front Immunol, 4, 305, 10.3389/fimmu.2013.00305 · DOI
- Sakaguchi, 2008, Regulatory T cells and immune tolerance, Cell, 133, 775, 10.1016/j.cell.2008.05.009 · DOI
- Maizels, 2011, Regulatory T cells in infection, Adv Immunol, 112, 73, 10.1016/B978-0-12-387827-4.00003-6 · DOI
- Correale, 2008, Helminth infections associated with multiple sclerosis induce regulatory B cells, Ann Neurol, 64, 187, 10.1002/ana.21438 · DOI
- Hussaarts, 2011, Regulatory B-cell induction by helminths: implications for allergic disease, J Allergy Clin Immunol, 128, 733, 10.1016/j.jaci.2011.05.012 · DOI · Paper page
- Labeaud, 2009, Do antenatal parasite infections devalue childhood vaccination?, PLoS Negl Trop Dis, 3, e442, 10.1371/journal.pntd.0000442 · DOI · Paper page
- Johnston, 2014, Helminths and immunological tolerance, Transplantation, 97, 127, 10.1097/TP.0b013e3182a53f59 · DOI
- Salgame, 2013, Effect of helminth-induced immunity on infections with microbial pathogens, Nat Immunol, 14, 1118, 10.1038/ni.2736 · DOI
- Wammes, 2010, Regulatory T cell in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum, Eur J Immunol, 40, 437, 10.1002/eji.200939699 · DOI
- Mishra, 2014, Systemic impact of intestinal helminth infections, Mucosal Immunol, 7, 753, 10.1038/mi.2014.23 · DOI
- Greenwood, 1968, Autoimmune disease and parasitic infections in Nigerians, Lancet, 2, 380, 10.1016/S0140-6736(68)90595-3 · DOI
- van den Biggelaar, 2000, Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10, Lancet, 356, 1723, 10.1016/S0140-6736(00)03206-2 · DOI
- van den Biggelaar, 2004, Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren, J Infect Dis, 189, 892, 10.1086/381767 · DOI · Paper page
- McKay, 2015, Not all parasites are protective, Parasite Immunol, 37, 324, 10.1111/pim.12160 · DOI
- Araujo, 2000, Inverse association between skin response to aeroallergen and Schistosoma mansoni infection, Int Arch Allergy Immunol, 123, 145, 10.1159/000024433 · DOI
- Cooper, 2003, Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics, J Allergy Clin Immunol, 111, 995, 10.1067/mai.2003.1348 · DOI
- Feary, 2011, Atopy and current intestinal parasite infection: a systematic review and meta-analysis, Allergy, 66, 569, 10.1111/j.1398-9995.2010.02512.x · DOI · Paper page
- Cooper, 2006, Human allergy and geohelminth infections: a review of the literature and a proposed conceptual model to guide the investigation of possible causal associations, Br Med Bull, 79–80, 203, 10.1093/bmb/ldl015 · DOI
- Smits, 2007, Protective effect of Schistosoma mansoni infection on allergic asthma depends on intensity and chronicity of infection, J Allergy Clin Immunol, 120, 932, 10.1016/j.jaci.2007.06.009 · DOI
- Flohr, 2010, Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam, Clin Exp Allergy, 40, 131, 10.1111/j.1365-2222.2009.03346.x · DOI · Paper page
- Mutapi, 2011, Schistosome infection intensity is inversely related to auto-reactive antibody levels, PLoS One, 6, e19149, 10.1371/journal.pone.0019149 · DOI
- Correale, 2007, Association between parasite infection and immune responses in multiple sclerosis, Ann Neurol, 61, 97, 10.1002/ana.21067 · DOI
- Correale, 2011, The impact of parasite infections on the course of multiple sclerosis, J Neuroimmunol, 233, 6, 10.1016/j.jneuroim.2011.01.002 · DOI · Paper page
- Broadhurst, 2010, IL-22+ CD4+ T cells are associated with therapeutic Trichuris trichiura infection in an ulcerative colitis patient, Sci Transl Med, 2, 60ra88, 10.1126/scitranslmed.3001500 · DOI
- Weinstock, 2013, Translatability of helminth therapy in inflammatory bowel diseases, Int J Parasitol, 43, 245, 10.1016/j.ijpara.2012.10.016 · DOI · Paper page
- Fleming, 2015, Clinical trials of helminth therapy in autoimmune diseases: rationale and findings, Parasite Immunol, 37, 277, 10.1111/pim.12175 · DOI
- Summers, 2003, Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease, Am J Gastroenterol, 98, 2034, 10.1111/j.1572-0241.2003.07660.x · DOI
- Summers, 2005, Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial, Gastroenterology, 128, 825, 10.1053/j.gastro.2005.01.005 · DOI · Paper page
- Summers, 2005, Trichuris suis therapy in Crohn's disease, Gut, 54, 87, 10.1136/gut.2004.041749 · DOI · Paper page
- Garg, 2014, Helminth therapy (worms) for induction of remission in inflammatory bowel disease, Cochrane Database Syst Rev, 1, CD009400
- Bager, 2010, Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial, J Allergy Clin Immunol, 125, 123, 10.1016/j.jaci.2009.08.006 · DOI
- Bourke, 2012, Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response, Clin Exp Allergy, 42, 1582, 10.1111/j.1365-2222.2012.04063.x · DOI · Paper page
- Jouvin, 2012, Trichuris suis ova: testing a helminth-based therapy as an extension of the hygiene hypothesis, J Allergy Clin Immunol, 130, 3, 10.1016/j.jaci.2012.05.028 · DOI
- Benzel, 2012, Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients, J Helminthol, 86, 339, 10.1017/S0022149X11000460 · DOI
- Fleming, 2011, Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study, Mult Scler, 17, 743, 10.1177/1352458511398054 · DOI
- Voldsgaard, 2015, Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect, Mult Scler, 21, 1723, 10.1177/1352458514568173 · DOI
- Fleming, 2014, Clinical trial of helminth-induced immunomodulatory therapy (HINT 2) in relapsing-remitting multiple sclerosis, Neurology, 82, 149
- Feary, 2009, Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study, Clin Exp Allergy, 39, 1060, 10.1111/j.1365-2222.2009.03187.x · DOI
- Feary, 2010, Experimental hookworm infection: a randomized placebo-controlled trial in asthma, Clin Exp Allergy, 40, 299, 10.1111/j.1365-2222.2009.03433.x · DOI · Paper page
- Croese, 2006, A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors, Gut, 55, 136, 10.1136/gut.2005.079129 · DOI · Paper page
- Daveson, 2011, Effect of hookworm infection on wheat challenge in celiac disease—a randomised double-blinded placebo controlled trial, PLoS One, 6, e17366, 10.1371/journal.pone.0017366 · DOI · Paper page
- Evans, 2015, Worms as therapeutics for allergy: understanding why benefits in animal studies have not translated into clinical success, J Allergy Clin Immunol, 135, 343, 10.1016/j.jaci.2014.07.007 · DOI
- Helmby, 2015, Human helminth therapy to treat inflammatory disorders—where do we stand?, BMC Immunol, 16, 12, 10.1186/s12865-015-0074-3 · DOI · Paper page
- Leonardi, 2015, Helminth therapy for organic diseases?, Transl Res, 166, 586, 10.1016/j.trsl.2015.06.016 · DOI
- Finlay, 2014, Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases, Immunol Rev, 259, 206, 10.1111/imr.12164 · DOI
- Johnston, 2009, Parasitic helminths: a pharmacopeia of anti-inflammatory molecules, Parasitology, 136, 125, 10.1017/S0031182008005210 · DOI
- Heylen, 2014, Of worms, mice and man: an overview of experimental and clinical helminth-based therapy for inflammatory bowel disease, Pharmacol Ther, 143, 153, 10.1016/j.pharmthera.2014.02.011 · DOI
- Harnett, 2010, Helminth-derived immunomodulators: can understanding the worm produce the pill?, Nat Rev Immunol, 10, 278, 10.1038/nri2730 · DOI
- McSorley, 2013, Immunomodulation by helminth parasites: defining mechanisms and mediators, Int J Parasitol, 43, 301, 10.1016/j.ijpara.2012.11.011 · DOI
- Shepherd, 2015, Identifying the immunomodulatory components of helminths, Parasite Immunol, 37, 293, 10.1111/pim.12192 · DOI · Paper page
- Hewitson, 2009, Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity, Mol Biochem Parasitol, 167, 1, 10.1016/j.molbiopara.2009.04.008 · DOI
- Schnoeller, 2008, A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages, J Immunol, 180, 4265, 10.4049/jimmunol.180.6.4265 · DOI
- Harnett, 2010, The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease, Clin Exp Immunol, 159, 256, 10.1111/j.1365-2249.2009.04064.x · DOI
- Navarro, 2013, The hookworm pharmacopoeia for inflammatory diseases, Int J Parasitol, 43, 225, 10.1016/j.ijpara.2012.11.005 · DOI
Cited by
Sorted by citations
Global issues in allergy and immunology: Parasitic infections and allergy
Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82
Packi, K., Świerczewski, D., Klimczak, S., Ochab, D., Gałęziewska, J., Gromek, P., Kruczkowska, W., Płuciennik, E., Kałuzińska-Kołat, Ż., & Kołat, D. (2026) · Antonie van Leeuwenhoek · doi:10.1007/s10482-026-02425-4
Metadata
- Authors
- Maizels, R. M.
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 22
- Issue
- 6
- Pages
- 481-486
- ISSN
- 1198-743X
- Cited by
- 121
- References
- 3
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review