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Cited by 54Tissue Engineering and Regenerative MedicineBone Tissue Engineering Materials3D Printing in Biomedical Research

The host response in tissue engineering: Crosstalk between immune cells and cell-laden scaffolds

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Saleh, Leila S., Bryant, Stephanie J.·2018·Current Opinion in Biomedical Engineering
DOI 10.1016/j.cobme.2018.03.006PMC PMC6203342
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Abstract

Implantation of cell-laden scaffolds is a promising strategy for regenerating tissue that has been damaged due to injury or disease. However, the act of implantation initiates an acute inflammatory response. If the scaffold is non-biologic (i.e., a modified biologic scaffold or synthetic-based scaffold), inflammation will be prolonged through the foreign body response (FBR), which eventually forms a fibrous capsule and walls off the implant from the surrounding host tissue. This host response, from a cellular perspective, can create a harsh environment leading to long-lasting effects on the tissue engineering outcome. At the same time, cells embedded within the scaffold can respond to this environment and influence the interrogating immune cells (e.g., macrophages). This crosstalk, depending on the type of cell, can dramatically influence the host response. This review provides an overview of the FBR and highlights important and recent advancements in the host response to cell-laden scaffolds with a focus on the impact of the communication between immune cells and cells embedded within a scaffold. Understanding this complex interplay between the immune cells, notably macrophages, and the tissue engineering cells is a critically important component to a successful in vivo tissue engineering therapy.

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  • Any in vivo intervention triggers intrinsic pathways leading to the inflammatory response.

    “Nowadays, this strategy does not seem effective as it is known that any in vivo intervention triggers intrinsic pathways leading to the inflammatory response [197].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [197]

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Cited by

Sorted by citations

Authors
Saleh, L. S., & Bryant, S. J.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Bryant, Stephanie J.
ORCID
Bryant, Stephanie J.
Venue
Current Opinion in Biomedical Engineering
Publisher
Elsevier BV
Published
2018-06
Volume
6
Pages
58-65
ISSN
2468-4511 (ISSN-L)
DOI
10.1016/j.cobme.2018.03.006
PMC
PMC6203342
OpenAlex
W2794627502
Cited by
54
References
6
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 1
FWCI
1.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Biomedical Engineering (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R01AR069060)
  • Department for Education
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
host response, cell-laden scaffolds, foreign body reaction, acute inflammation, macrophages, fibrous capsule, scaffold implantation, tissue engineering

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