Cited by 45Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

Multimodal EEG-fMRI: advancing insight into large-scale human brain dynamics

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Chang, Catie, Chen, Jingyuan E.·2021·Current Opinion in Biomedical Engineering

Abstract

Advances in the acquisition and analysis of functional magnetic resonance imaging (fMRI) data are revealing increasingly rich spatiotemporal structure across the human brain. Nonetheless, uncertainty surrounding the origins of fMRI hemodynamic signals, and in the link between large-scale fMRI patterns and ongoing functional states, presently limits the neurobiological conclusions one can draw from fMRI alone. Electroencephalography (EEG) provides complementary information about neural electrical activity and state change, and simultaneously acquiring EEG together with fMRI presents unique opportunities for studying large-scale brain activity and gaining more information from fMRI itself. Here, we discuss recent progress in the use of concurrent EEG-fMRI to enrich the investigation of neural and physiological states and clarify the origins of fMRI hemodynamic signals. Throughout, we outline perspectives on future directions and open challenges.

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  • Aligning and integrating EEG with fMRI data has shown potential for providing deeper insights into human brain dynamics.

    “Additionally, aligning and integrating EEG with functional magnetic resonance imaging (fMRI) data has shown potential for providing deeper insights into human brain dynamics [106].”

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  1. [60]Chen JE, Fultz NE, Polimeni JR, Catana C, Rosen BR, Lewis LD, Sander CY: Employing simultaneous functional PET/MRI to map neuronal and vascular dynamics accompanying brain arousal fluctuations. In Proceedings of the 28th Annual Meeting of ISMRM; 2020: 1359.

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Authors
Chang, C., & Chen, J. E.
Affiliations
  • Vanderbilt University (US)
  • Harvard University (US)
Corresponding author
Chang, Catie
Venue
Current Opinion in Biomedical Engineering
Publisher
Elsevier BV
Published
2021-06
Volume
18
Pages
100279
ISSN
2468-4511 (ISSN-L)
OpenAlex
W3137332104
Cited by
45
References
63
Citations by year
2026: 11 · 2025: 16 · 2024: 8 · 2023: 4 · 2022: 3 · 2021: 3
FWCI
0.66
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (K22ES028048, K99NS118120, R01NS112252)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
EEG-fMRI, neural oscillations, neural states, spatiotemporal brain activity, multimodal neuroimaging

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