Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep
Open accessAbstract
Fluid dynamics during sleep: During non–rapid eye movement sleep, low-frequency oscillations in neural activity support memory consolidation and neuronal computation. Sleep is also associated with increased interstitial fluid volume and clearance of metabolic waste products. It is unknown why these processes co-occur and how they are related. Fultz et al. simultaneously measured electrophysiological, hemodynamic, and flow signals in the human brain (see the Perspective by Grubb and Lauritzen). Large oscillations of fluid inflow to the brain appeared during sleep and were tightly coupled to functional magnetic resonance imaging signals and entrained to electroencephalogram slow waves. Slow oscillatory neuronal activity thus leads to oscillations in blood volume, drawing cerebrospinal fluid into and out of the brain. Science , this issue p. 628 ; see also p. 572
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Waves of CSF flow appear during sleep in human brain, and it is possible that tau and Aβ clearance is enhanced by CSF circulation, which may be impaired by SD.
“Using advanced neuroimaging, a recent study reveals that waves of CSF flow appear during sleep in human brain. It is possible that tau and Aβ clearance is enhanced by CSF circulation, which may be impaired by SD [573].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [573]
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- Authors
- Fultz, N. E., Bonmassar, G., Setsompop, K., Stickgold, R. A., Rosen, B. R., Polimeni, J. R., & Lewis, L. D.
- Affiliations
- Boston University (US)
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA.
- Corresponding author
- Lewis, Laura D.
- ORCID
- Venue
- Science
- Published
- 2019-11
- Volume
- 366
- Issue
- 6465
- Pages
- 628-631
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7309589
- OpenAlex
- W2982626951
- Cited by
- 1,197
- References
- 54
- Citations by year
- 2026: 235 · 2025: 240 · 2024: 174 · 2023: 177 · 2022: 116 · 2021: 148 · 2020: 97 · 2019: 7 · 2018: 1
- FWCI
- 53.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P41-EB015896, S10-RR023043, S10-OD010759)
- National Institute of Mental Health (R00-MH111748, R01MH048832, R01MH111419, R01-MH111438)
- National Institute of Neurological Disorders and Stroke (R21NS106706)
- National Institute of Biomedical Imaging and Bioengineering (R01EB019437, R01EB024343)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- sleep, cerebrospinal fluid flow, slow waves, neural oscillations, hemodynamic oscillations, NREM sleep, memory consolidation, brain waste clearance
- MeSH terms
- Adult, Brain, Cerebrospinal Fluid, Cerebrovascular Circulation, Delta Rhythm, Electroencephalography, Female, Hemodynamics, Humans, Magnetic Resonance Imaging, Male, Sleep, Young Adult, Brain Waves
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