Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study

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New Insights into a Conceptual Bionic Colonic Bioreactor: A Model, ‘Probiotics in Human Colon’, Showing How Probiotics Alleviate Constipation from a Bioprocess Engineering Perspective

Wang, N., Wu, P., & Chen, X. D. (2025) · Foods · doi:10.3390/foods14081335 · Cited by 4 · see citing works

Probiotics combination effectively improves constipation in pregnancy by modifying the gut microbiota composition

He, X., Chen, W., Wang, Y., Chen, H., Xu, X., Zhao, X., Zhou, D., Yue, M., Wei, J., & Chen, T. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00020 · Cited by 4 · see citing works

The Alleviative Effects of Weizmannia coagulans CGMCC 9951 on the Reproductive Toxicity of Caenorhabditis elegans Induced by Polystyrene Microplastics

Li, C., Zhao, L., Fan, J., Qi, W., Li, X., Li, Y., Tian, P., Wu, Y., & Gu, S. (2025) · Microorganisms · doi:10.3390/microorganisms13030497 · Cited by 3 · see citing works

A systematic study of Pseudobulbus Cremastrae seu Pleiones: Characteristics, Origin, chemical composition and toxicology

Zhou, C., Jia, Y., Zhang, Q., Huang, W., Yan, J., Ying, X., & Zhang, H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118923 · Cited by 2 · see citing works

Seoul Consensus on Clinical Practice Guidelines for Functional Constipation

Song, K. H., Cho, Y. S., Shin, J. E., Jung, H., Park, S., Kang, S. J., Kim, J., Lee, Y. J., Lim, H. C., Park, H. S., et al. (2025) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2024.156 · Cited by 2 · see citing works

Protective Effect of Pediococcus pentosaceus Li05 on Constipation via TGR5/TPH1/5‐HT Activation

Chen, H., Wang, F., Li, S., Lv, L., Xu, H., Xia, J., Xu, L., Shi, D., & Li, L. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70257 · Cited by 2 · see citing works

Impact of Heyndrickxia (Bacillus) coagulans GBI-30, 6086 (BC30) probiotic on gastrointestinal function in healthy adults: a randomised controlled trial

Gang, H., Wei, J., McFarland, L. V., Zahra, R., Saez, M. E., Blanco-Rojo, R., & Millette, M. (2025) · Beneficial Microbes · doi:10.1163/18762891-bja00084 · Cited by 1 · see citing works

Efficacy of Bacillus clausii UBBC-07 and Bacillus coagulans Unique IS-2 in Mitigating Pulmonary Parameters in Patients With Moderate COVID-19 Symptoms

Mirza, M. A., Bandaru, R. K., & Ushasree, T. (2024) · Cureus · doi:10.7759/cureus.76436 · Cited by 1 · see citing works

Constipation targeted monostrain and multispecies probiotics: effects on symptoms and gut microbiota

Zeng, Y., He, P., Lyu, C., Wu, Y., Zhao, X., Gu, Q., Wu, S., Zhang, Y., Wei, X., An, R., et al. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250509 · Cited by 1 · see citing works

The Cornell Library and Its Contributions to Open Access

Thomas, S. (2005) · eCommons (Cornell University)

Eficácia de probióticos na sintomatologia da constipação funcional em adultos: uma revisão integrativa

Santucci, L. F., & Bezerra, A. N. (2024) · Gestão & Cuidado em Saúde. · doi:10.70368/gecs.v2i1.12153

Bacillus coagulans Unique IS2 improves stool characteristics in healthy adults with infrequent bowel movements: a randomized, double-blind, placebo-controlled trial

LeMoire, A., Replogle, R. A., Shinn, L. M., Kamil, A., Lin, L., Kuttenkeuler, A. P., Baisley, J. E., Wang, J., Girard, S., Recker, S., et al. (2025) · Beneficial Microbes · doi:10.1163/18762891-bja00072

Dietary Supplementation with the Probiotic Bacillus velezensis BV379 Decreases Abdominal Bloating Without Perturbing the Commensal Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults

Garvey, S. M., Blonquist, T. M., Brutscher, L. M., Walsh, D. M., Kaden, V. N., Beckman, D., Zeng, M., Bruno, R. S., Cook, C. M., & Spears, J. L. (2025) · Journal of the American Nutrition Association · doi:10.1080/27697061.2025.2563894

Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: A randomized, double-blind, placebo-controlled trial

Park, H. G., Lee, H. B., Lee, M., Park, H., Kang, M., Bok, M., Hwang, Y., Jeong, K., Maeng, S., Lim, H., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0337019

Targeting Gut Microbiota in the Management of Functional Constipation: A Narrative Review

Takeda, T., Hojo, M., Asaoka, D., & Nagahara, A. (2025) · Internal Medicine · doi:10.2169/internalmedicine.6457-25

Bacillus coagulans: basic and applied aspects

Sil, M., Banerjee, S., Mukherjee, N., Ghosh, A., Goswami, A., & Polikarpov, I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40483-2.00038-8

Clinical Guidance and Practical Recommendations for Probiotic Use in Patients with Irritable Bowel Syndrome, Functional Constipation, and Clostridioides difficile Infection Considering Sex-Based Differences

Kim, Y. W., Park, S.-Y., Kang, S. J., Lee, M. W., Choi, Y., Kim, B. Y., Choi, M., Shin, C. M., Kim, Y. W., Kim, N., et al. (2026) · Sex- and Gender-Specific Biomedicine · doi:10.65400/sgbm.2026.1.2.85

Synbiotic Supplementation With Heyndrickxia coagulans TBC169 Improves Chronic Constipation in Middle‐Aged and Elderly

Zhou, X., Guo, C., Hu, G., Ding, L., Zou, T., Wang, M., Xiong, W., Deng, W., Wei, J., Yu, J., et al. (2026) · Biotechnology Journal · doi:10.1002/biot.70250

Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study

Venkataraman, R., Shenoy, R., Ahire, J. J., Neelamraju, J., & Madempudi, R. S. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09855-8 · Cited by 27 · see citing works

Bacillus Coagulans Unique IS2 Improves Stool Characteristics In Healthy Adults With Infrequent Bowel Movements: A Randomized, Double-Blind, Placebo-Controlled Trial

Shinn, L. M., Kamil, A., LeMoire, A., Replogle, R. A., Lin, L., Kuttenkeuler, A. P., Baisley, J. E., Wang, J., Girard, S., Recker, S., et al. (2025) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2025.107171

Weizmannia coagulans BC01 supplementation improved functional constipation by regulating gut microbiota: A randomized, placebo-controlled, clinical study

Xu, Y., Zhang, Y., Yue, F., Yu, X., Chen, Y., & Ma, X. (2025) · Medicine · doi:10.1097/md.0000000000046861 · Cited by 2 · see citing works

Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults

Madempudi, R. S., Ahire, J. J., Neelamraju, J., Tripathi, A., & Nanal, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-48554-x · Cited by 77 · see citing works

Eficácia de probióticos na sintomatologia da constipação funcional em adultos: uma revisão integrativa

Santucci, L. F., & Bezerra, A. N. (2024) · Gestão & Cuidado em Saúde. · doi:10.70368/gecs.v2i1.12153