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Cited by 1,329

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

Open access
Topalian, Suzanne L, Drake, Charles G, Pardoll, Drew M·2012·Current Opinion in Immunology
DOI 10.1016/j.coi.2011.12.009
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Abstract

Genetic alterations and epigenetic dysregulation in cancer cells create a vast array of neoepitopes potentially recognizable by the immune system. Immune checkpoint blockade has the capacity to enhance and sustain endogenous immunity against non-mutated tumor-associated antigens as well as uniquely mutant antigens, establishing durable tumor control. Recent evidence from preclinical models highlights the pivotal role of the Programmed Death-1 (PD-1) T cell co-receptor and its ligands, B7-H1/PD-L1 and B7-DC/PD-L2, in maintaining an immunosuppressive tumor microenvironment. Encouraging early clinical results using blocking agents against components of the PD-1 pathway have validated its importance as a target for cancer immunotherapy.

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Crossref · 10.1016/j.coi.2011.12.009

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Metadata

Authors
Topalian, S. L., Drake, C. G., & Pardoll, D. M.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2012-04
Volume
24
Issue
2
Pages
207-212
ISSN
0952-7915 (ISSN-L)
DOI
10.1016/j.coi.2011.12.009
OpenAlex
W1984545852
Cited by
1,329
References
12
FWCI
10.94
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.