Cited by 551Immune cells in cancerAngiogenesis and VEGF in CancerCancer, Stress, Anesthesia, and Immune Response

Tumor-associated macrophages: Functional diversity, clinical significance, and open questions

Biswas, Subhra K., Allavena, Paola, Mantovani, Alberto·2013·Seminars in Immunopathology

Abstract

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and human tumors. While epidemiological studies indicate a clear correlation between TAM density and poor prognosis in a number of human cancers, transgenic studies and transcriptome profiling of TAMs in mice have established their crucial role in cancer progression. In fact, TAMs affect diverse aspects of cancer progression including tumor cell growth and survival, invasion, metastasis, angiogenesis, inflammation, and immunoregulation. New evidences have extended the repertoire of these cells to other tumor promoting activities like interactions with cancer stem cells, response to chemotherapy, and tumor relapse. These findings have triggered efforts to target TAMs and their associated molecules to modulate tumor progression. In particular, "re-education" to activate their anti-tumor potential or elimination of tumor promoting TAMs are strategies undergoing preclinical and clinical evaluation. Proof-of-principle studies indicate that TAM-centered therapeutic strategies may contribute to cancer therapy.

Integrity signals

Registry

Crossref · 10.1007/s00281-013-0367-7

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • High hydrophilicity and unfavorable pharmacokinetics of several chelators do not allow reaching effective intratumoral concentrations.

    “Moreover, the high hydrophilicity and unfavorable pharmacokinetics of several chelators do not allow reaching effective intratumoral concentrations [59].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Biswas, S. K., Allavena, P., & Mantovani, A.
Affiliations
  • Agency for Science, Technology and Research (SG)
  • University of Milan (IT)
Corresponding author
  • Biswas, Subhra K.
  • Mantovani, Alberto
Venue
Seminars in Immunopathology
Published
2013-05-09
Volume
35
Issue
5
Pages
585-600
ISSN
  • 1863-2297 (ISSN-L)
  • 1863-2300
OpenAlex
W1991129425
Cited by
551
References
144
Citations by year
2026: 12 · 2025: 33 · 2024: 42 · 2023: 43 · 2022: 48 · 2021: 55 · 2020: 59 · 2019: 42 · 2018: 48 · 2017: 55 · 2016: 42 · 2015: 35 · 2014: 29 · 2013: 8
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Immunopathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Associazione Italiana per la Ricerca sul Cancro
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords
tumor-associated macrophages, TAM heterogeneity, tumor inflammation, tumor progression, metastasis, angiogenesis, immune regulation, cancer stem cells, chemotherapy response, tumor recurrence
MeSH terms
Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Genetic Variation, Cytokines, Disease Progression, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review