Tumor-associated macrophages: Functional diversity, clinical significance, and open questions
Abstract
Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and human tumors. While epidemiological studies indicate a clear correlation between TAM density and poor prognosis in a number of human cancers, transgenic studies and transcriptome profiling of TAMs in mice have established their crucial role in cancer progression. In fact, TAMs affect diverse aspects of cancer progression including tumor cell growth and survival, invasion, metastasis, angiogenesis, inflammation, and immunoregulation. New evidences have extended the repertoire of these cells to other tumor promoting activities like interactions with cancer stem cells, response to chemotherapy, and tumor relapse. These findings have triggered efforts to target TAMs and their associated molecules to modulate tumor progression. In particular, "re-education" to activate their anti-tumor potential or elimination of tumor promoting TAMs are strategies undergoing preclinical and clinical evaluation. Proof-of-principle studies indicate that TAM-centered therapeutic strategies may contribute to cancer therapy.
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“Moreover, the high hydrophilicity and unfavorable pharmacokinetics of several chelators do not allow reaching effective intratumoral concentrations [59].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [59]
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- Authors
- Biswas, S. K., Allavena, P., & Mantovani, A.
- Affiliations
- Agency for Science, Technology and Research (SG)
- University of Milan (IT)
- Corresponding author
- Biswas, Subhra K.
- Mantovani, Alberto
- Venue
- Seminars in Immunopathology
- Published
- 2013-05-09
- Volume
- 35
- Issue
- 5
- Pages
- 585-600
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W1991129425
- Cited by
- 551
- References
- 144
- Citations by year
- 2026: 12 · 2025: 33 · 2024: 42 · 2023: 43 · 2022: 48 · 2021: 55 · 2020: 59 · 2019: 42 · 2018: 48 · 2017: 55 · 2016: 42 · 2015: 35 · 2014: 29 · 2013: 8
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Seminars in Immunopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- tumor-associated macrophages, TAM heterogeneity, tumor inflammation, tumor progression, metastasis, angiogenesis, immune regulation, cancer stem cells, chemotherapy response, tumor recurrence
- MeSH terms
- Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Genetic Variation, Cytokines, Disease Progression, Mice
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