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Short-term forms of presynaptic plasticity
Open accessAbstract
Synapses exhibit several forms of short-term plasticity that play a multitude of computational roles. Short-term depression suppresses neurotransmitter release for hundreds of milliseconds to tens of seconds; facilitation and post-tetanic potentiation lead to synaptic enhancement lasting hundreds of milliseconds to minutes. Recent advances have provided insight into the mechanisms underlying these forms of plasticity. Vesicle depletion, as well as inactivation of both release sites and calcium channels, contribute to synaptic depression. Mechanisms of short-term enhancement include calcium channel facilitation, local depletion of calcium buffers, increases in the probability of release downstream of calcium influx, altered vesicle pool properties, and increases in quantal size. Moreover, there is a growing appreciation of the heterogeneity of vesicles and release sites and how they can contribute to use-dependent plasticity.
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“Short-term synaptic plasticity can increase or decrease the strength of a synaptic signal several-fold (Fioravante and Regehr, 2011).”
From The Presynaptic Active Zone (2012) · cites this paper as Fioravante and Regehr, 2011
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Metadata
- Authors
- Fioravante, D., & Regehr, W. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Regehr, Wade G
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 21
- Issue
- 2
- Pages
- 269-274
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3599780
- OpenAlex
- W1975727393
- Cited by
- 375
- References
- 64
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 22 · 2023: 16 · 2022: 26 · 2021: 26 · 2020: 23 · 2019: 37 · 2018: 34 · 2017: 25 · 2016: 26 · 2015: 29 · 2014: 28 · 2013: 22 · 2012: 24
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R37 NS032405)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- short-term plasticity, short-term depression, short-term facilitation, post-tetanic potentiation, neurotransmitter release, vesicle depletion, calcium buffers, quantal size, release sites, vesicle heterogeneity, use-dependent plasticity
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synaptic Vesicles, Calcium Channels, Presynaptic Terminals
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