Effects of two combined oral contraceptives containing ethinyl estradiol 20 μg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism
Abstract
Objective To compare the effect of ethinyl estradiol 20 microg/drospirenone 3 mg (EE 20 microg/DRSP 3 mg) administered according to a 24/4 regimen with ethinyl estradiol 20 microg/desogestrel 150 microg (EE 20 microg/DSG 150 microg) administered according to the conventional 21/7 regimen on lipid, carbohydrate and hemostatic parameters.Study design In this open-label study, healthy women were randomized to EE 20 microg/DRSP 3 mg or EE 20 microg/DSG 150 microg for seven cycles. Mean differences in high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels at cycle 7 compared to baseline were assessed. Secondary variables included changes in other lipid, hemostatic and carbohydrate parameters.Results Both treatments increased HDL-cholesterol, but decreased LDL-cholesterol by a comparable extent. Although slightly elevated in both groups, blood glucose and C-peptide levels measured during oral glucose tolerance tests were within normal reference ranges at cycle 7. Overall, the differences in lipid, hemostatic or carbohydrate parameters were not significant between the two treatments.Conclusion EE 20 microg/DRSP 3 mg has a good safety profile comparable with EE 20 microg/DSG 150 microg.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
COCs with a more androgenic progestin, such as LNG, show a decrease in HDL-C and an increase in LDL-C, while COCs with a newer progestin, such as DRSP, have a more favorable effect on lipids.
“COCs with a more androgenic progestin, such as LNG, show a decrease in HDLC and an increase in LDL-C, while COCs with a newer progestin, such as DRSP, have a more favorable effect on lipids [ 26 , 27 ].”
From Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone (2021) · cites this paper as [26]
Cites
Drospirenone: pharmacology and pharmacokinetics of a unique progestogen
Krattenmacher, R. (2000) · Contraception · doi:10.1016/s0010-7824(00)00133-5 · Cited by 375 · see citing works
The analysis of vaginal bleeding patterns induced by fertility regulating methods
Belsey, E. M., Machines, D., & d’Arcangues, C. (1986) · Contraception · doi:10.1016/0010-7824(86)90006-5 · Cited by 250 · see citing works
Oelkers, W., Foidart, J. M., Dombrovicz, N., Welter, A., & Heithecker, R. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.6.7775629 · Cited by 247 · see citing works
Extending the duration of active oral contraceptive pills to manage hormone withdrawal symptoms
Sulak, P. J., Cressman, B. E., Waldrop, E., Holleman, S., & Kuehl, T. J. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(96)00488-7 · Cited by 171 · see citing works
Evaluation of a new generation of oral contraceptives. The Advisory Board for the New Progestins.
Speroff, L., & DeCherney, A. H. (1993) · PubMed · Cited by 164 · see citing works
Huber, J., Foidart, J., Wuttke, W., Merki‐Feld, G. S., The, H. S., Gerlinger, C., Schellschrmdt, I., & Heithecker, R. (2000) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625180008500375 · Cited by 147 · see citing works
Spellacy, W. N. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32479-6 · Cited by 134 · see citing works
Diczfalusy, E. (1986) · Contraception · doi:10.1016/0010-7824(86)90003-x · Cited by 125 · see citing works
Foidart, J. M., Wuttke, W., Gm, B., Gerlinger, C., & Heithecker, R. (2000) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625180008500387 · Cited by 121 · see citing works
The metabolic impact of oral contraceptives
Krauss, R. M., & Burkman, R. T. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(12)90408-1 · Cited by 82 · see citing works
Metabolic effects of oral contraceptives
GASPARD, U. J. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80128-x · Cited by 79 · see citing works
Gaspard, U., Scheen, A., Endrikat, J., Buicu, C., Lefebvre, P., Gerlinger, C., & Heithecker, R. (2003) · Contraception · doi:10.1016/s0010-7824(02)00537-1 · Cited by 72 · see citing works
Gaspard, U., Endrikat, J., Desager, J. P., Buicu, C., Gerlinger, C., & Heithecker, R. (2004) · Contraception · doi:10.1016/j.contraception.2003.11.003 · Cited by 70 · see citing works
Clinical implications. Biological coagulation findings in third-generation oral contraceptives
Conard, J. (1999) · Human Reproduction Update · doi:10.1093/humupd/5.6.672 · Cited by 63 · see citing works
Endrikat, J., Klipping, C., Cronin, M., Gerlinger, C., Ruebig, A., Schmidt, W., & Düsterberg, B. (2002) · Contraception · doi:10.1016/s0010-7824(01)00316-x · Cited by 57 · see citing works
Self-citationKnopp, R. H., Broyles, F. E., Cheung, M. C., Moore, K. H., Marcovina, S. M., & Chandler, W. L. (2001) · Contraception · doi:10.1016/s0010-7824(00)00196-7 · Cited by 56 · see citing works
Crook, D., Godsland, I. F., Worthington, M., Felton, C. V., Proudler, A. J., & Stevenson, J. C. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90279-r · Cited by 46 · see citing works
Oelkers, W. (2000) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/14730782.2000.12288986 · Cited by 43 · see citing works
Wiegratz, I., Jung-Hoffmann, C., Gross, W., & Kühl, H. (1998) · Contraception · doi:10.1016/s0010-7824(98)00074-2 · Cited by 37 · see citing works
Si, S., Chen, J.-K., Yang, P.-J., Mei-li, H., La-mei, L., Bao-chuan, F., Rekers, H., & Fotherby, K. (1992) · Contraception · doi:10.1016/0010-7824(92)90103-z · Cited by 37 · see citing works
Foidart, J. (2000) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/14730782.2000.12288987 · Cited by 32 · see citing works
Endrikat, J., Klipping, C., Gerlinger, C., Ruebig, A., Schmidt, W., Holler, T., & Düsterberg, B. (2001) · Contraception · doi:10.1016/s0010-7824(01)00236-0 · Cited by 28 · see citing works
Self-citationLüdicke, F., GASPARD, U. J., Demeyer, F., Scheen, A. J., & Lefebvre, P. (2002) · Contraception · doi:10.1016/s0010-7824(02)00415-8 · Cited by 27 · see citing works
Lipid metabolism effects with desogestrel-containing oral contraceptives
Burkman, R. T. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90334-f · Cited by 25 · see citing works
Metabolic profile of six oral contraceptives containing norgestimate, gestodene, and desogestrel.
Teichmann, A. T. (1995) · PubMed · Cited by 23 · see citing works
Fruzzetti, F., Genazzani, A. R., Ricci, C., et al. (2001) · Contraception · doi:10.1016/s0010-7824(01)00213-x · Cited by 20 · see citing works
Effects of desogestrel on carbohydrate metabolism
Shoupe, D. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90335-g · Cited by 20 · see citing works
Yasmin — a New Oral Contraceptive, a New Progestogen: The Reasons Why
Mansour, D. (2000) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/14730782.2000.12288985 · Cited by 18 · see citing works
The Evolution of Oral Contraceptives: Maximizing Efficacy, Minimizing Risks
Hedon, B. (1990) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349009156500 · Cited by 14 · see citing works
Ja, L., Ha, D. P., Ma, D.-R., et al. (1989) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Steroidal contraceptives: effect on carbohydrate metabolism in women without diabetes mellitus
Lopez, L. M., Grimes, D. A., & Schulz, K. F. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006133.pub5 · Cited by 166 · see citing works
Metabolic effects of contraceptive steroids
Sitruk-Ware, R., & Nath, A. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9182-4 · Cited by 161 · see citing works
Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone
Klipping, C., Duijkers, I., Mawet, M., Maillard, C., Bastidas, A., Jost, M., & Foidart, J.-M. (2021) · Contraception · doi:10.1016/j.contraception.2021.01.001 · Cited by 108 · see citing works
Self-citationJunge, W., Mellinger, U., Parke, S., & Serrani, M. (2011) · Clinical Drug Investigation · doi:10.2165/11590220-000000000-00000 · Cited by 107 · see citing works
Kluft, C., Zimmerman, Y., Mawet, M., Klipping, C., Duijkers, I. J. M., Neuteboom, J., Foidart, J.-M., & Bennink, H. C. (2017) · Contraception · doi:10.1016/j.contraception.2016.08.018 · Cited by 94 · see citing works
Self-citationMaloney, J. M., Dietze, P., Watson, D., Niknian, M., Lee-Rugh, S., Sampson-Landers, C., & Korner, P. (2008) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e318187e1c5 · Cited by 68 · see citing works
Blood Pressure Effects of the Oral Contraceptive and Postmenopausal Hormone Therapies
Boldo, A., & White, W. B. (2011) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2011.01.008 · Cited by 54 · see citing works
Effects of oral contraceptives on metabolic parameters in adult premenopausal women: a meta-analysis
Silva-Bermudez, L. S., Toloza, F. J. K., Perez-Matos, M. C., de Souza, R. J., Banfield, L., Vargas-Villanueva, A., & Mendivil, C. O. (2020) · Endocrine Connections · doi:10.1530/ec-20-0423 · Cited by 52 · see citing works
- Authors
- Klipping, C., & Marr, J.
- Corresponding author
- Marr, Joachim
- ORCID
- Klipping, Christine
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 71
- Issue
- 6
- Pages
- 409-416
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W2070217907
- Cited by
- 90
- References
- 31
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- combined oral contraceptives, drospirenone, desogestrel, lipid profile, HDL cholesterol, LDL cholesterol, hemostatic parameters, carbohydrate metabolism, glucose tolerance, C-peptide, blood glucose, contraceptive safety
- MeSH terms
- Adult, Androstenes, Contraceptives, Oral, Hormonal, Drug Combinations, Ethinyl Estradiol, Female, Hemostasis, Humans, Desogestrel, Carbohydrate Metabolism, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
