A randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on carbohydrate metabolism
Open accessAbstract
In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (Marvelon) on variables of carbohydrate metabolism by means of oral glucose tolerance tests at baseline and in the 6th and 13th treatment cycle. The mean levels of fasting glucose and insulin were similar at baseline and after 13 treatment cycles, whereas C-peptide and free fatty acid levels decreased slightly in both groups. All blood glucose and insulin values measured in the oral glucose tolerance tests were within normal ranges, despite a slight increase in the mean areas under the curves of 0-3 h [AUCs (0-3 h)] of both variables from baseline to treatment cycle 13. Differences between both treatments were not statistically significant. The mean AUCs (0-3 h) for C-peptide were not markedly changed in any treatment group. Free fatty acid levels decreased by 42% in the drospirenone group and increased by 48.9% in the desogestrel group, in terms of means of individual changes. Both preparations were well tolerated and equally efficacious regarding contraception and cycle control. The mean body weight was slightly decreased in most cycles during treatment with the drospirenone combination, as compared to baseline, while it was slightly increased versus baseline in all cycles during treatment with the desogestrel combination. The combination with drospirenone had less impact on blood pressure than the combination with desogestrel. In conclusion, Yasmin, a combined low-dose oral contraceptive with 30 microg ethinylestradiol and 3 mg of the novel progestogen drospirenone, as well as the reference Marvelon, containing 30 microg ethinylestradiol and 150 microg desogestrel had little impact on carbohydrate metabolism when used for 1 year. The observed changes were small and not suggestive of a clinically relevant deterioration of carbohydrate metabolism.
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More recently, marketed COCs appear to be more neutral on carbohydrate metabolism.
“More recently, marketed COCs appear to be more neutral on carbohydrate metabolism [4] .”
From Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone (2021) · cites this paper as [4]
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Contraception and diabetes: Which modalities should we consider in 2021?
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Therapeutic Aspects of Polycystic Ovary Syndrome in Adolescence
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Effect on Endoplasmic Reticulum Stress of the Combined Oral Contraceptives in the Liver
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- Authors
- Gaspard, U., Scheen, A., Endrikat, J., Buicu, C., Lefebvre, P., Gerlinger, C., & Heithecker, R.
- Affiliations
- University of Liège (BE)
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 67
- Issue
- 6
- Pages
- 423-429
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W2149112955
- Cited by
- 72
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 5
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- orbi.uliege.be
- Licence
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- oral contraceptives, drospirenone, desogestrel, ethinyl estradiol, Yasmin, Marvelon, carbohydrate metabolism, glucose tolerance, insulin, C-peptide, free fatty acids, body weight, blood pressure, progestogens, low-dose estrogen
- MeSH terms
- Adolescent, Adult, Androstenes, Blood Glucose, Blood Pressure, Body Weight, C-Peptide, Contraceptives, Oral, Combined, Ethinyl Estradiol, Fasting, Fatty Acids, Nonesterified, Female, Glucose Tolerance Test, Humans, Insulin, Kinetics, Desogestrel, Carbohydrate Metabolism
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