Metabolic engineering for bioproduction of sugar alcohols
Abstract
Sugar alcohols find applications in pharmaceuticals, oral and personal care products, and as intermediates in chemical synthesis. While industrial-scale production of these compounds has generally involved catalytic hydrogenation of sugars, microbial-based processes receive increasing attention. The past few years have seen a variety of interesting metabolic engineering efforts to improve the capabilities of bacteria and yeasts to overproduce xylitol, mannitol, and sorbitol. Examples include heterologous expression of yeast xylose reductase in Escherichia coli for the production of xylitol, coexpression of formate dehydrogenase, mannitol dehydrogenase, and a glucose facilitator protein in Corynebacterium glutamicum for mannitol production from fructose and formate, and overexpression of sorbitol-6-phosphate dehydrogenase in lactate dehydrogenase-deficient Lactobacillus plantarum to achieve nearly maximum theoretical yields of sorbitol from glucose.
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Sugar fermentations to produce polyols such as sorbitol, mannitol, xylitol are feasible although they cannot yet compete with chemical reduction economically.
“Sugar fermentations to produce these polyols are also feasible although it cannot yet compete with the chemical reduction economically.[149][150][151]”
From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [149]
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- Authors
- Akinterinwa, O., Khankal, R., & Cirino, P. C.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Cirino, Patrick Carmen
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 19
- Issue
- 5
- Pages
- 461-467
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2166128021
- Cited by
- 123
- References
- 46
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 2 · 2019: 12 · 2018: 8 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 12
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- sugar alcohols, xylitol, mannitol, sorbitol, metabolic engineering, microbial production, xylose reductase, heterologous expression, formate dehydrogenase, mannitol dehydrogenase, Corynebacterium glutamicum, Lactobacillus plantarum, sorbitol-6-phosphate dehydrogenase
- MeSH terms
- Bacterial Proteins, Genetic Engineering, Sugar Alcohols, Signal Transduction, Bacterial Physiological Phenomena, Proteome, Metabolomics
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