Cited by 123Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionMicrobial metabolism and enzyme function

Metabolic engineering for bioproduction of sugar alcohols

Akinterinwa, Olubolaji, Khankal, Reza, Cirino, Patrick Carmen·2008·Current Opinion in Biotechnology

Abstract

Sugar alcohols find applications in pharmaceuticals, oral and personal care products, and as intermediates in chemical synthesis. While industrial-scale production of these compounds has generally involved catalytic hydrogenation of sugars, microbial-based processes receive increasing attention. The past few years have seen a variety of interesting metabolic engineering efforts to improve the capabilities of bacteria and yeasts to overproduce xylitol, mannitol, and sorbitol. Examples include heterologous expression of yeast xylose reductase in Escherichia coli for the production of xylitol, coexpression of formate dehydrogenase, mannitol dehydrogenase, and a glucose facilitator protein in Corynebacterium glutamicum for mannitol production from fructose and formate, and overexpression of sorbitol-6-phosphate dehydrogenase in lactate dehydrogenase-deficient Lactobacillus plantarum to achieve nearly maximum theoretical yields of sorbitol from glucose.

Integrity signals

Registry

Crossref · 10.1016/j.copbio.2008.08.002

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46 of 46 references verified0 citation errors · 0 not checkable

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  • Sugar fermentations to produce polyols such as sorbitol, mannitol, xylitol are feasible although they cannot yet compete with chemical reduction economically.

    “Sugar fermentations to produce these polyols are also feasible although it cannot yet compete with the chemical reduction economically.[149][150][151]”

    From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [149]

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Authors
Akinterinwa, O., Khankal, R., & Cirino, P. C.
Affiliations
Pennsylvania State University (US)
Corresponding author
Cirino, Patrick Carmen
Venue
Current Opinion in Biotechnology
Publisher
Elsevier BV
Published
2008-10
Volume
19
Issue
5
Pages
461-467
ISSN
0958-1669 (ISSN-L)
OpenAlex
W2166128021
Cited by
123
References
46
Citations by year
2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 2 · 2019: 12 · 2018: 8 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 12
FWCI
0.62
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords
sugar alcohols, xylitol, mannitol, sorbitol, metabolic engineering, microbial production, xylose reductase, heterologous expression, formate dehydrogenase, mannitol dehydrogenase, Corynebacterium glutamicum, Lactobacillus plantarum, sorbitol-6-phosphate dehydrogenase
MeSH terms
Bacterial Proteins, Genetic Engineering, Sugar Alcohols, Signal Transduction, Bacterial Physiological Phenomena, Proteome, Metabolomics

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