Cellulosic ethanol: status and innovation
Open accessAbstract
Although the purchase price of cellulosic feedstocks is competitive with petroleum on an energy basis, the cost of lignocellulose conversion to ethanol using today's technology is high. Cost reductions can be pursued via either in-paradigm or new-paradigm innovation. As an example of new-paradigm innovation, consolidated bioprocessing using thermophilic bacteria combined with milling during fermentation (cotreatment) is analyzed. Acknowledging the nascent state of this approach, our analysis indicates potential for radically improved cost competitiveness and feasibility at smaller scale compared to current technology, arising from (a) R&D-driven advances (consolidated bioprocessing with cotreatment in lieu of thermochemical pretreatment and added fungal cellulase), and (b) configurational changes (fuel pellet coproduction instead of electricity, gas boiler(s) in lieu of a solid fuel boiler).
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Advanced biofuel production costs are higher than their fossil counterparts.
“Their production costs [19][20][21] however are higher than their fossil counterparts [22]”
From Advanced biofuels to decarbonise European transport by 2030: markets, challenges, and policies that impact their successful market uptake (2021) · cites this paper as [22]
The current cellulosic BP pathway is broadly consistent with the six pioneer commercial-scale cellulosic biorefineries that had been constructed worldwide as of 2017, with a combined nameplate annual production capacity of 450 million L.
“This pathway is broadly consistent with the six pioneer commercial-scale cellulosic biorefineries that had been constructed worldwide as of 2017, with a combined nameplate annual production capacity of 450 million L ( 58 ).”
From Robust paths to net greenhouse gas mitigation and negative emissions via advanced biofuels (2020) · cites this paper as [58]
Continued research, development, and iterative limited-scale deployment of bioenergy and CCS systems are essential for realizing improvements and cost reductions in biorefining and CCS technology in support of existing renewable fuel mandates and in time for midcentury wide-scale deployment of CDR.
“We note that continued research, development, and iterative limited-scale deployment of such systems are essential for realizing improvements and cost reductions in biorefining and CCS technology ( 58 , 59 ) in support of existing renewable fuel mandates and in time for the midcentury wide-scale deployment of CDR called for in many projections.”
From Robust paths to net greenhouse gas mitigation and negative emissions via advanced biofuels (2020) · cites this paper as [58]
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Microbial Cellulose Utilization: Fundamentals and Biotechnology
Lynd, L. R., Weimer, P. J., van Zyl, W. H., & Pretorius, I. S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.506-577.2002 · Cited by 4,726 · see citing works
Self-citationBiomass Recalcitrance: Engineering Plants and Enzymes for Biofuels Production
Himmel, M. E., Ding, S.-Y., Johnson, D. K., Adney, W. S., Nimlos, M. R., Brady, J. W., & Foust, T. D. (2007) · Science · doi:10.1126/science.1137016 · Cited by 4,538 · see citing works
Self-citationHumbird, D., Davis, R., Tao, L., Kinchin, C., Hsu, D., Aden, A., Schoen, P., Lukas, J., Olthof, B., Worley, M., et al. (2011) · doi:10.2172/1013269 · Cited by 1,641 · see citing works
How biotech can transform biofuels
Lynd, L. R., Laser, M. S., Bransby, D., Dale, B. E., Davison, B., Hamilton, R., Himmel, M., Keller, M., McMillan, J. D., Sheehan, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt0208-169 · Cited by 1,121 · see citing works
Self-citationThe challenge of enzyme cost in the production of lignocellulosic biofuels
Klein‐Marcuschamer, D., Oleśkowicz-Popiel, P., Simmons, B. A., & Blanch, H. W. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.24370 · Cited by 1,000 · see citing works
Lynd, L. R., Wyman, C. E., & Gerngross, T. U. (1999) · Biotechnology Progress · doi:10.1021/bp990109e · Cited by 723 · see citing works
Self-citationIndustrial biomanufacturing: The future of chemical production
Clomburg, J. M., Crumbley, A. M., & González, R. (2017) · Science · doi:10.1126/science.aag0804 · Cited by 555 · see citing works
Perennial grasslands enhance biodiversity and multiple ecosystem services in bioenergy landscapes
Werling, B. P., Dickson, T. L., Isaacs, R., Gaines, H., Gratton, C., Gross, K. L., Liere, H., Malmstrom, C. M., Meehan, T. D., Ruan, L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309492111 · Cited by 460 · see citing works
Ethanol learning curve—the Brazilian experience
Goldemberg, J., Coelho, S. T., Nastari, P. M., & Lucon, O. D. S. (2003) · Biomass and Bioenergy · doi:10.1016/s0961-9534(03)00125-9 · Cited by 379 · see citing works
Sustainable Development of the Agricultural Bio-Economy
Jordan, N., Boody, G., Broussard, W., Glover, J. D., Keeney, D., McCown, B. H., McIsaac, G., Muller, M., Murray, H., Neal, J., et al. (2007) · Science · doi:10.1126/science.1141700 · Cited by 321 · see citing works
High octane number ethanol–gasoline blends: Quantifying the potential benefits in the United States
Anderson, J. E., Dicicco, D., Ginder, J. M., et al. (2012) · Fuel · doi:10.1016/j.fuel.2012.03.017 · Cited by 245 · see citing works
Explaining the experience curve: Cost reductions of Brazilian ethanol from sugarcane
Bake, J. D. V. D. W., Junginger, M., Faaij, A. P. C., Poot, T., & Walter, A. C. D. S. (2008) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2008.10.006 · Cited by 210 · see citing works
Stephen, J. D., Mabee, W. E., & Saddler, J. N. (2011) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.331 · Cited by 199 · see citing works
Understanding the reductions in US corn ethanol production costs: An experience curve approach
Hettinga, W., Junginger, M., Dekker, S. C., Hoogwijk, M. M., McAloon, A. J., & Hicks, K. B. (2008) · Energy Policy · doi:10.1016/j.enpol.2008.08.002 · Cited by 192 · see citing works
The need for biofuels as part of a low carbon energy future
Fulton, L. M., Lynd, L. R., Körner, A., Greene, N., & Tonachel, L. (2015) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.1559 · Cited by 170 · see citing works
Self-citationResch, M. G., Donohoe, B. S., Baker, J. O., et al. (2013) · Energy & Environmental Science · doi:10.1039/c3ee00019b · Cited by 164 · see citing works
Simultaneous achievement of high ethanol yield and titer in Clostridium thermocellum
Tian, L., Papanek, B., Olson, D. G., Rydzak, T., Holwerda, E. K., Zheng, T., Zhou, J., Maloney, M., Jiang, N., Giannone, R. J., et al. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0528-8 · Cited by 150 · see citing works
Self-citationPaye, J. M. D., Guseva, A., Hammer, S. K., Gjersing, E. L., Davis, M. F., Davison, B. H., Olstad, J. L., Donohoe, B. S., Nguyen, T. Y., Wyman, C. E., et al. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-015-0412-y · Cited by 128 · see citing works
Self-citationDramatic performance of Clostridium thermocellum explained by its wide range of cellulase modalities
Xu, Q., Resch, M. G., Podkaminer, K., Yang, S., Baker, J. O., Donohoe, B. S., Wilson, C. M., Klingeman, D. M., Olson, D. G., Decker, S. R., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501254 · Cited by 125 · see citing works
Self-citationBioenergy and African transformation
Lynd, L. R., Sow, M., Chimphango, A. F. A., Cortez, L. A., Cruz, C. H. B., Elmissiry, M., Laser, M. S., Mayaki, I. A., de Moraes, M. A. F. D., Nogueira, L. A. H., et al. (2015) · Biotechnology for Biofuels · doi:10.1186/s13068-014-0188-5 · Cited by 88 · see citing works
Self-citationBalch, M. L., Holwerda, E. K., Davis, M. F., Sykes, R. W., Happs, R. M., Kumar, R., Wyman, C. E., & Lynd, L. R. (2017) · Energy & Environmental Science · doi:10.1039/c6ee03748h · Cited by 84 · see citing works
Self-citationStrain and bioprocess improvement of a thermophilic anaerobe for the production of ethanol from wood
Herring, C. D., Kenealy, W. R., Shaw, A. J., et al. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0536-8 · Cited by 74 · see citing works
Lynd, L. R., Guss, A. M., Himmel, M. E., Beri, D., Herring, C., Holwerda, E. K., Murphy, S. J.-L., Olson, D. G., Paye, J. M. D., Rydzak, T., et al. (2016) · Industrial Biotechnology · doi:10.1002/9783527807796.ch10 · Cited by 61 · see citing works
Self-citationConverting plant biomass to fuels and commodity chemicals in South Africa: a third chapter?
Lynd, L. R., von Blottnitz, H., Tait, B., de Boer, J., Pretorius, I. S., Rumbold, K., & van Zyl, W. H. (2003) · Open University of Cape Town (University of Cape Town) · Cited by 27 · see citing works
Self-citationA Review of Cost Estimation in New Technologies
Merrow, E. W., Chapel, S. W., & Worthing, C. (1979) · Cited by 14 · see citing works
Thomas, J. F., Office of Sustainable Transportation. Bioenergy Technologies Office (BETO) USDOE Office of Energy Efficiency and Renewable Energy (EERE), Office of Sustainable Transportation. Vehicle Technologies Office (VTO) USDOE Office of Energy Efficiency and Renewable Energy (EERE), et al. (2015) · doi:10.2172/1185964 · Cited by 11 · see citing works
Petroleum Refining: Economic Performance and Challenges for the Future
Pirog, R. L. (2008) · University of North Texas Digital Library (University of North Texas) · Cited by 8 · see citing works
Current state of the US ethanol industry
US Department of Energy Office of Biomass Programs (2011) · Industrial Biotechnology · doi:10.1089/ind.2011.7.127 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 12
- [2]2. Souza GM, Victoria RL, Verdade LM, Joly CA, Netto PEA, Cantarella H, Chum HL, Diaz-Chavez R, Fernandes E, Fincher G, et al.: Bioenergy Numbers . In Bioenergy & Sustainability: Bridging the gaps. Edited by Souza GM, Victoria RL, Joly CA, Verdade LM. SCOPE, Paris; 2015:28-57. - Bioenergy Numbers is a useful compilation of information within a comprehensive report addressing various aspects of bioenergy merit and potential.
- [14]14. U.S. Department of Energy: Lignocellulosic Biomass for Advanced Biofuels and Bioproducts: Workshop Report . 2015. DOE SC-0170. - An examination of the scientific barriers to expanding the bioeconomy based on lignocellulosic feedstocks, including recognition of the continuing importance of the recalcitrance barrier as an impediment to cost-competitive production.
- [20]20. Lynd LR, Guss AM, Himmel ME, Beri D, Herring C, Holwerda EK, Murphy SJ, Olson DG, Paye J, Rydzak T, et al.: Advances in Consolidated Bioprocessing Using Clostridium thermocellum and Thermoanaerobacter saccharolyticum . In Industrial Biotechnology . . Wiley-VCH Verlag GmbH & Co. KGaA; 2017:365-394.
- [33]33. Lynd LR, Wyman C, Laser M, Johnson D, Landucci R: Strategic Biorefinery Analysis: Review of Existing Biorefinery Examples . 2005.
- [35]35. De Mes TZD, Stams AJM, Reith JH, Zeeman G: Chapter 4. Methane production by anaerobic digestion of wastewater and solid wastes . In Bio-methane & Bio-hydrogen. Status and perspectives of biological methane and hydrogen production . Edited by Reith JH, Wijffels RH, Barten H. 2003:58-102.
- [36]36. Ramirez EC, Johnston DB, McAloon AJ, Yee W, Singh V: Engineering process and cost model for a conventional corn wet milling facility . Ind. Crops Prod. 2008, 27 :9197.
- [37]37. Hideno A, Inoue H, Tsukahara K, Fujimoto S, Minowa T, Inoue S, Endo T, Sawayama S: Wet disk milling pretreatment without sulfuric acid for enzymatic hydrolysis of rice straw . Bioresour. Technol. 2009, 100 :2706-2711.
- [38]38. Sultana A, Kumar A, Harfield D: Development of agri-pellet production cost and optimum size . Bioresour. Technol. 2010, 101 :5609-5621.
- [39]39. Lavenson DM, Tozzi EJ, Karuna N, Jeoh T, Powell RL, McCarthy MJ: The effect of mixing on the liquefaction and saccharification of cellulosic fibers . Bioresour. Technol. 2012, 111 :240-7.
- [40]40. Skovgaard PA, Thygesen LG, Jørgensen H, Cardona M, Tozzi E, McCarthy M, Siika-Aho M, Jeoh T: The role of endoglucanase and endoxylanase in liquefaction of hydrothermally pretreated wheat straw . Biotechnol. Prog. 2014, 30 :923-931. - A paper documenting the pronounced liquifaction and changes in physical properties that occurs during the initial stages of lignocellulose solubilization.
- [41]41. Wang M, Han J, Dunn JB, Cai H, Elgowainy A, D A, Arora S WMWM, Bergerson J A KOCADSS and MHL, Borrion A L MMC and HGP, J B do C, et al.: Well-to-wheels energy use and greenhouse gas emissions of ethanol from corn, sugarcane and cellulosic biomass for US use . Environ. Res. Lett. 2012, 7 :45905.
- [42]42. Qin Z, Dunn JB, Kwon H, Mueller S, Wander MM: Influence of spatially dependent, modeled soil carbon emission factors on life-cycle greenhouse gas emissions of corn and cellulosic ethanol . GCB Bioenergy 2016, 8 :1136-1149.
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“This pathway is broadly consistent with the six pioneer commercial-scale cellulosic biorefineries that had been constructed worldwide as of 2017, with a combined nameplate annual production capacity of 450 million L (58).”
Self-citationForsberg, C. W., Dale, B. E., Jones, D. S., Hossain, T., Morais, A. R. C., & Wendt, L. M. (2021) · Applied Energy · doi:10.1016/j.apenergy.2021.117225 · Cited by 60 · see citing works
- Authors
- Lynd, L. R., Liang, X., Biddy, M. J., Allee, A., Cai, H., Foust, T., Himmel, M. E., Laser, M. S., Wang, M., & Wyman, C. E.
- Affiliations
- Dartmouth College (US)
- National Laboratory of the Rockies (US)
- Argonne National Laboratory (US)
- University of California, Riverside (US)
- Corresponding author
- Lynd, Lee R
- ORCID
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 45
- Pages
- 202-211
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2615538334
- Cited by
- 402
- References
- 28
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 44 · 2023: 35 · 2022: 36 · 2021: 62 · 2020: 68 · 2019: 55 · 2018: 43 · 2017: 19 · 2016: 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 351 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Opinion in Biotechnology (acceptedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- US Department of Energy Office of Biological and Environmental Research through the Bioenergy Science Center (DE-AC05-00OR22725)
- Bioenergy Technology Office (BETO) of the Office of Energy Efficiency and Renewable Energy of the U.S. Department of Energy (DE-AC02-06CH11357)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Bioenergy crop production and management
- Keywords
- cellulosic ethanol, lignocellulose conversion, consolidated bioprocessing, thermophilic bacteria, thermochemical pretreatment, fungal cellulases, process cost reduction, scale-up, biofuels
- MeSH terms
- Ethanol, Cellulase, Cellulose, Fermentation, Fungi, Lignin, Biofuels
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