Cited by 281Bone Metabolism and DiseasesBone health and osteoporosis researchRheumatoid Arthritis Research and Therapies

Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength.

KOSTENUIK, P·2005·Current Opinion in Pharmacology

Abstract

Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) are dominant regulators of bone resorption. Many hormones, cytokines and growth factors mediate bone resorption by altering the ratio of RANKL to OPG. RANKL and OPG expression is also altered in numerous bone diseases, and these changes can reflect disease etiology or compensatory responses to disease. RANKL stimulates osteoclast formation, function and survival, and each of these effects is inhibited by OPG. OPG suppresses bone resorption and increases the density, area and strength of both cancellous and cortical bone. Denosumab (AMG 162), a fully human monoclonal antibody to RANKL, shares the pharmacologic attributes of OPG but has a significantly longer half-life that allows less frequent administration.

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Crossref · 10.1016/j.coph.2005.06.005

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Authors
KOSTENUIK, P.
Affiliations
Amgen (United States) (US)
Corresponding author
KOSTENUIK, P
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2005-12
Volume
5
Issue
6
Pages
618-625
ISSN
1471-4892 (ISSN-L)
OpenAlex
W2055763817
Cited by
281
References
54
Citations by year
2026: 8 · 2025: 15 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 8 · 2017: 9 · 2016: 17 · 2015: 16 · 2014: 11 · 2013: 13 · 2012: 19
FWCI
7.15
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
osteoprotegerin, RANKL, bone resorption, RANKL/OPG ratio, osteoclasts, bone mineral density, bone geometry, bone strength, denosumab, monoclonal antibodies, bone disease, RANK signaling
MeSH terms
Denosumab, Animals, Antibodies, Monoclonal, Bone Resorption, Carrier Proteins, Glycoproteins, Humans, Membrane Glycoproteins, Osteoclasts, Bone Density, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Antibodies, Monoclonal, Humanized

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