The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Gut microbiota, enteroendocrine functions and metabolism
Abstract
The gut microbiota affects host metabolism through a number of physiological processes. Emerging evidence suggests that gut microbes interact with the host through several pathways involving enteroendocrine cells (e.g. L cells). The activation of specific G protein coupled receptors expressed on L cells (e.g. GPR41, GPR43, GPR119 and TGR5) triggers the secretion of glucagon-like peptides (GLP-1 and GLP-2) and PYY. These gut peptides are known to control energy homeostasis, glucose metabolism, gut barrier function and metabolic inflammation. Here, we explore how crosstalk between the ligands produced by the gut microbiota (short chain fatty acids, or SCFAs), or produced by the host but influenced by gut microbes (endocannabinoids and bile acids), impact host physiology.
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In the citing paper
“The microbiota regulates, via different mechanisms, some important physiological functions of the host, such as those related to energy expenditure, satiety and glucose homeostasis [10,11] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [10]
In the citing paper
“The GM can stimulate the release of peptides and hormones from enteroendocrine cells, which can have direct or indirect central effects (22, 39).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [39]
In the citing paper
“In the gut, the GM and its metabolites have been shown to modulate gastrointestinal functions via their effects on intestinal permeability (32–35), mucosal immune function (36–38), intestinal motility and sensitivity (39, 40), and the enteric nervous system (ENS) (21, 24, 25, 41).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [39]
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Cites
A metagenome-wide association study of gut microbiota in type 2 diabetes
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Self-citationObesity alters gut microbial ecology
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The gut microbiota shapes intestinal immune responses during health and disease
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Self-citationCross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
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Self-citationFunctional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Gut metagenome in European women with normal, impaired and diabetic glucose control
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Human nutrition, the gut microbiome and the immune system
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386
Self-citationStress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150
The Human Microbiota in Health and Disease
Wang, B., Yao, M., Lv, L., Ling, Z., & Li, L. (2017) · Engineering · doi:10.1016/j.eng.2017.01.008 · Cited by 916
Metadata
- Authors
- Cani, P. D., Everard, A., & Duparc, T.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Corresponding author
- Cani, Patrice D
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 13
- Issue
- 6
- Pages
- 935-940
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2044719746
- Cited by
- 378
- References
- 61
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 21 · 2023: 26 · 2022: 31 · 2021: 37 · 2020: 45 · 2019: 34 · 2018: 48 · 2017: 36 · 2016: 29 · 2015: 21 · 2014: 16 · 2013: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- gut microbiota, enteroendocrine cells, L cells, G protein-coupled receptors, GPR41, GPR43, GPR119, TGR5, glucagon-like peptide-1, glucagon-like peptide-2, peptide YY, short-chain fatty acids, endocannabinoids, bile acids, energy homeostasis, glucose metabolism, intestinal barrier, metabolic inflammation
- MeSH terms
- Animals, Gastrointestinal Hormones, Humans, Enteroendocrine Cells, Gastrointestinal Tract, Microbiota
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