Cited by 378Gut microbiota and healthGastrointestinal motility and disordersRegulation of Appetite and Obesity

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Gut microbiota, enteroendocrine functions and metabolism

Cani, Patrice D, Everard, Amandine, Duparc, Thibaut·2013·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2013.09.008

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Abstract

The gut microbiota affects host metabolism through a number of physiological processes. Emerging evidence suggests that gut microbes interact with the host through several pathways involving enteroendocrine cells (e.g. L cells). The activation of specific G protein coupled receptors expressed on L cells (e.g. GPR41, GPR43, GPR119 and TGR5) triggers the secretion of glucagon-like peptides (GLP-1 and GLP-2) and PYY. These gut peptides are known to control energy homeostasis, glucose metabolism, gut barrier function and metabolic inflammation. Here, we explore how crosstalk between the ligands produced by the gut microbiota (short chain fatty acids, or SCFAs), or produced by the host but influenced by gut microbes (endocannabinoids and bile acids), impact host physiology.

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Authors: Cani, P. D., Everard, A., & Duparc, T.
Affiliations: Walloon Excellence in Lifesciences and Biotechnology (BE)
Corresponding author: Cani, Patrice D
ORCID: Cani, Patrice D
Everard, Amandine
Duparc, Thibaut
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2013-12
Volume: 13
Issue: 6
Pages: 935-940
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2013.09.008
OpenAlex: W2044719746
Cited by: 378
References: 61
Citations by year: 2026: 16 · 2025: 17 · 2024: 21 · 2023: 26 · 2022: 31 · 2021: 37 · 2020: 45 · 2019: 34 · 2018: 48 · 2017: 36 · 2016: 29 · 2015: 21 · 2014: 16 · 2013: 1
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: gut microbiota, enteroendocrine cells, L cells, G protein-coupled receptors, GPR41, GPR43, GPR119, TGR5, glucagon-like peptide-1, glucagon-like peptide-2, peptide YY, short-chain fatty acids, endocannabinoids, bile acids, energy homeostasis, glucose metabolism, intestinal barrier, metabolic inflammation
MeSH terms: Animals, Gastrointestinal Hormones, Humans, Enteroendocrine Cells, Gastrointestinal Tract, Microbiota

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Gut microbiota, enteroendocrine functions and metabolism

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