The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Gut microbiota, enteroendocrine functions and metabolism
Abstract
The gut microbiota affects host metabolism through a number of physiological processes. Emerging evidence suggests that gut microbes interact with the host through several pathways involving enteroendocrine cells (e.g. L cells). The activation of specific G protein coupled receptors expressed on L cells (e.g. GPR41, GPR43, GPR119 and TGR5) triggers the secretion of glucagon-like peptides (GLP-1 and GLP-2) and PYY. These gut peptides are known to control energy homeostasis, glucose metabolism, gut barrier function and metabolic inflammation. Here, we explore how crosstalk between the ligands produced by the gut microbiota (short chain fatty acids, or SCFAs), or produced by the host but influenced by gut microbes (endocannabinoids and bile acids), impact host physiology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The microbiota regulates, via different mechanisms, some important physiological functions of the host, such as those related to energy expenditure, satiety and glucose homeostasis [10,11] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [10]
In the citing paper
“The GM can stimulate the release of peptides and hormones from enteroendocrine cells, which can have direct or indirect central effects (22, 39).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [39]
In the citing paper
“In the gut, the GM and its metabolites have been shown to modulate gastrointestinal functions via their effects on intestinal permeability (32–35), mucosal immune function (36–38), intestinal motility and sensitivity (39, 40), and the enteric nervous system (ENS) (21, 24, 25, 41).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [39]
Citations
Cites
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Self-citationObesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Self-citationCross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Self-citationFunctional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
Self-citationBrown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770
Self-citationBercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Immune adaptations that maintain homeostasis with the intestinal microbiota
Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,530
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512
Lin, H. V., Frassetto, A., Kowalik Jr, E. J., Nawrocki, A. R., Lu, M. M., Kosinski, J. R., Hubert, J. A., Szeto, D., Yao, X., Forrest, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035240 · Cited by 1,378
Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364
Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., Possemiers, S., Van Holle, A., François, P., de Vos, W. M., et al. (2011) · Diabetes · doi:10.2337/db11-0227 · Cited by 1,076
Self-citationThe influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052
Induction of intestinal epithelial proliferation by glucagon-like peptide 2.
Drucker, D. J., Erlich, P., Asa, S. L., & Brubaker, P. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7911 · Cited by 888
Farnesoid X receptor is essential for normal glucose homeostasis
Ma, K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25604 · Cited by 883
Brun, P., Castagliuolo, I., Leo, V. D., Buda, A., Pinzani, M., Palù, G., & Martines, D. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2006 · Cited by 880
Santacruz, A., Collado, M. C., García-Valdés, L., Segura, M. T., Martín-Lagos, J. A., Anjos, T., Martí-Romero, M., Lopez, R. M., Florido, J., Campoy, C., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000176 · Cited by 868
Targeting gut microbiota in obesity: effects of prebiotics and probiotics
Delzenne, N. M., Neyrinck, A. M., Bäckhed, F., & Cani, P. D. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.126 · Cited by 805
Self-citationGlucose Sensing in L Cells: A Primary Cell Study
Reimann, F., Habib, A. M., Tolhurst, G., Parker, H. E., Rogers, G. J., & Gribble, F. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.002 · Cited by 733 · cited 1×
“Among the enteroendocrine cells, L cells have attracted particular interest because of the pleiotropic effects of their secreted peptides [7–9].”
BackgroundThe endocannabinoid system links gut microbiota to adipogenesis
Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691
Self-citationDiabetes, obesity and gut microbiota
Everard, A., & Cani, P. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.007 · Cited by 578
Self-citationKaraki, S.-I., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J. B., & Kuwahara, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0140-x · Cited by 473
Cani, P. D., Knauf, C., Iglesias, M. A., Drucker, D. J., Delzenne, N. M., & Burcelin, R. (2006) · Diabetes · doi:10.2337/db05-1360 · Cited by 420
Self-citationLauffer, L. M., Iakoubov, R., & Brubaker, P. L. (2009) · Diabetes · doi:10.2337/db08-1237 · Cited by 405
Expression of short-chain fatty acid receptor GPR41 in the human colon
Tazoe, H., Otomo, Y., Karaki, S.-I., Kato, I., Fukami, Y., TERASAKI, M., & Kuwahara, A. (2009) · Biomedical Research · doi:10.2220/biomedres.30.149 · Cited by 346
Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept
for the D.E.S.I.R. Study Group, Amar, J., Sérino, M., Lange, C., Chabo, C., Iacovoni, J. S., Mondot, S., Lepage, P., Klopp, C., Mariette, J., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2329-8 · Cited by 335
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
Claus, S. P., Tsang, T. M., Wang, Y., Cloarec, O., Skordi, E., Martin, F., Rezzi, S., Ross, A., Kochhar, S., Holmes, E., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.56 · Cited by 334
Tarini, J., & Wolever, T. M. S. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-119 · Cited by 304
2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans
Hansen, K. B., ROSENKILDE, M. M., Knop, F. K., Wellner, N., Diep, T. A., Rehfeld, J. F., Andersen, U. B., Holst, J. J., & Hansen, H. S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0647 · Cited by 298
Dewulf, E. M., Cani, P. D., Neyrinck, A. M., Possemiers, S., Holle, A. V., Muccioli, G. G., Deldicque, L., Bindels, L. B., Pachikian, B. D., Sohet, F. M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.05.009 · Cited by 276
Self-citationNishino, R., Mikami, K., Takahashi, H., Tomonaga, S., Furuse, M., Hiramoto, T., Aiba, Y., Koga, Y., & Sudo, N. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12110 · Cited by 266
G-Protein-Coupled Receptors in Intestinal Chemosensation
Reimann, F. M., Tolhurst, G., & Gribble, F. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.019 · Cited by 245
Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion
Parker, H. E., Wallis, K., le Roux, C. W., Wong, K. Y., Reimann, F. M., & Gribble, F. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01561.x · Cited by 234
Neyrinck, A. M., Hée, V. F. V., Piront, N., Backer, F. D., Toussaint, O., Cani, P. D., & Delzenne, N. M. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2011.24 · Cited by 223
Self-citationIncreased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota
Duca, F. A., Swartz, T. D., Sakar, Y., & Covasa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039748 · Cited by 181
Kaji, I., Karaki, S.-I., Tanaka, R., & Kuwahara, A. (2010) · Journal of Molecular Histology · doi:10.1007/s10735-010-9304-4 · Cited by 155
Targeted nanoparticles with novel non-peptidic ligands for oral delivery
Rieux, A. D., Pourcelle, V., Cani, P. D., Marchand‐Brynaert, J., & Véronique Préat, A. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.01.002 · Cited by 149
Self-citationMicrobial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes
Donohoe, D. R., Wali, A., Brylawski, B. P., & Bultman, S. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046589 · Cited by 145
Regulation of GPR119 receptor activity with endocannabinoid-like lipids
Syed, S. K., Bui, H. H., Beavers, L. S., Farb, T. B., FICORILLI, J. V., Chesterfield, A. K., Kuo, M., Bokvist, K. B., Barrett, D. G., & Efanov, A. M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00269.2012 · Cited by 130
A Western Diet Increases Serotonin Availability in Rat Small Intestine
Bertrand, R. L., Senadheera, S. N., Markus, I., Liu, L., Howitt, L., Chen, H., Murphy, T. V., Sandow, S. L., & Bertrand, P. P. (2010) · Endocrinology · doi:10.1210/en.2010-0377 · Cited by 100
Anastasovska, J., Arora, T., Sanchez-Canon, G. J., Parkinson, J. R. C., Tuohy, K. M., Gibson, G. R., Nadkarni, N. A., So, P., Goldstone, A. P., Thomas, E. L., et al. (2012) · Obesity · doi:10.1038/oby.2012.6 · Cited by 90
A framework for identification of infections that contribute to human obesity
Dhurandhar, N. V. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70274-2 · Cited by 88
Plaisancié, P., Dumoulin, V., Chayvialle, J. A., & Cuber, J.-C. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1450521 · Cited by 79
Lee, S., Lee, J., Li, K. K., Holland, D. P., Maughan, H., Guttman, D. S., Yusta, B., & Drucker, D. J. (2012) · Endocrinology · doi:10.1210/en.2011-1954 · Cited by 76
Serotonin Receptor Type 3 Antagonists Improve Obesity-Associated Fatty Liver Disease in Mice
Haub, S., Ritze, Y., Ladel, I., Ebert, K., Hubert, A., Spruss, A., Trautwein, C., & Bischoff, S. C. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.181834 · Cited by 63
Charrier, J. A., Martin, R. J., McCutcheon, K. L., Raggio, A. M., Goldsmith, F., Goita, M., Senevirathne, R. N., Brown, I. L., Pelkman, C., Zhou, J., et al. (2013) · Obesity · doi:10.1002/oby.20362 · Cited by 59
Moran, G. W., O’Neill, C. A., & McLaughlin, J. (2012) · Regulatory Peptides · doi:10.1016/j.regpep.2012.07.002 · Cited by 52
Harnessing the beneficial properties of adipogenic microbes for improving human health
Dhurandhar, N. V., Geurts, L., Atkinson, R. L., Casteilla, L., Clément, K., Gérard, P., Vijay‐Kumar, M., Nam, J. H., Nieuwdorp, M., Trovato, G. M., et al. (2013) · Obesity Reviews · doi:10.1111/obr.12045 · Cited by 13
Self-citationKrüger, C., Kumar, K. G., Mynatt, R. L., Vólaufová, J., & Richards, B. K. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041709 · Cited by 11
When commonsense does not make sense
Dhurandhar, N. V. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.100 · Cited by 11
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386
Self-citationStress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150
The Human Microbiota in Health and Disease
Wang, B., Yao, M., Lv, L., Ling, Z., & Li, L. (2017) · Engineering · doi:10.1016/j.eng.2017.01.008 · Cited by 916
Metadata
- Authors
- Cani, P. D., Everard, A., & Duparc, T.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Corresponding author
- Cani, Patrice D
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 13
- Issue
- 6
- Pages
- 935-940
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2044719746
- Cited by
- 378
- References
- 61
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 21 · 2023: 26 · 2022: 31 · 2021: 37 · 2020: 45 · 2019: 34 · 2018: 48 · 2017: 36 · 2016: 29 · 2015: 21 · 2014: 16 · 2013: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- gut microbiota, enteroendocrine cells, L cells, G protein-coupled receptors, GPR41, GPR43, GPR119, TGR5, glucagon-like peptide-1, glucagon-like peptide-2, peptide YY, short-chain fatty acids, endocannabinoids, bile acids, energy homeostasis, glucose metabolism, intestinal barrier, metabolic inflammation
- MeSH terms
- Animals, Gastrointestinal Hormones, Humans, Enteroendocrine Cells, Gastrointestinal Tract, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
