The complex role of NRF2 in cancer: A genomic view

Comprehensive molecular profiling of lung adenocarcinoma

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Comprehensive genomic characterization of squamous cell lung cancers

The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994 · see citing works

Discovery and saturation analysis of cancer genes across 21 tumour types

Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · see citing works

Comprehensive molecular characterization of urothelial bladder carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/za09-dk57 · Cited by 2,992 · see citing works

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277 · see citing works

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947 · see citing works

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Schulze, K., Imbeaud, S., Letouzé, E., Alexandrov, L. B., Calderaro, J., Rebouissou, S., Couchy, G., Meiller, C., Shinde, J., Soysouvanh, F., et al. (2015) · Nature Genetics · doi:10.1038/ng.3252 · Cited by 1,803 · see citing works

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8137-8151.2003 · Cited by 1,480 · see citing works

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Guichard, C., Amaddeo, G., Imbeaud, S., Ladeiro, Y., Pelletier, L., Benmaad, I., Caldéraro, J., Bioulac‐Sage, P., Letexier, M., Degos, F., et al. (2012) · Nature Genetics · doi:10.1038/ng.2256 · Cited by 1,451 · see citing works

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395 · see citing works

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

The Cancer Genome Atlas Research Network (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505917 · Cited by 1,336 · see citing works

The emerging role of the Nrf2–Keap1 signaling pathway in cancerPreprint

Jaramillo, M. C., & Zhang, D. D. (2013) · Genes & Development · doi:10.1101/gad.225680.113 · Cited by 1,304 · see citing works

Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Zhang, D. D., Lo, S., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,262 · see citing works

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102 · see citing works

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060 · see citing works

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

Lau, A., Wang, X.-J., Zhao, F. L., Villeneuve, N. F., Wu, T., Jiang, T., Sun, Z., White, E., & Zhang, D. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00248-10 · Cited by 851 · see citing works

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Malhotra, D., Portales-Casamar, É., Singh, A., Srivastava, S., Arenillas, D. J., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq212 · Cited by 796 · see citing works

SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01204-10 · Cited by 759 · see citing works

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.013 · Cited by 735 · see citing works

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works

Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast

Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., & Tolédano, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16040 · Cited by 567 · see citing works

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

Chorley, B. N., Campbell, M. R., Wang, X., Karaca, M., Sambandan, D., Bangura, F., Xue, P., Pi, J., Kleeberger, S. R., & Bell, D. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks409 · Cited by 557 · see citing works

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

Itoh, K., Mimura, J., & Yamamoto, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3222 · Cited by 513 · see citing works

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

McMahon, M. J., Lamont, D. J., Beattie, K. A., & Hayes, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007387107 · Cited by 445 · see citing works

p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells

Umemura, A., He, F., Taniguchi, K., Nakagawa, H., Yamachika, S., Font-Burgada, J., Zhong, Z., Subramaniam, S., Raghunandan, S., Duran, A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.006 · Cited by 438 · see citing works

Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features

Solis, L. M., Behrens, C., Dong, W., Suraokar, M. B., Ozburn, N. C., Moran, C. A., Corvalán, A. H., Biswal, S. S., Swisher, S. G., Bekele, B. N., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3352 · Cited by 430 · see citing works

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

Homma, S., Ishii, Y., Morishima, Y., Yamadori, T., Matsuno, Y., Haraguchi, N., Kikuchi, N., Satoh, H., Sakamoto, T., Hizawa, N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2822 · Cited by 417 · see citing works

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

Ooi, A., Wong, J.-C., Petillo, D., Roossien, D., Perrier-Trudova, V., Whitten, D., Min, B. W. H., Tan, M.-H., Zhang, Z., Yang, X. J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.024 · Cited by 401 · see citing works

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

Mitsuishi, Y., Motohashi, H., & Yamamoto, M. P. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00200 · Cited by 394 · see citing works

skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

Bowerman, B. A., Eaton, B. A., & Priess, J. R. (1992) · Cell · doi:10.1016/0092-8674(92)90078-q · Cited by 374 · see citing works

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisPreprint

Wu, T., Zhao, F. L., Gao, B., Tan, C., Yagishita, N., Nakajima, T., Wong, P. K., Chapman, E., Fang, D., & Zhang, D. D. (2014) · Genes & Development · doi:10.1101/gad.238246.114 · Cited by 355 · see citing works

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., Yehuda‐Shnaidman, E., Lee, C., Lau, J., Kurtz, T. W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093955 · Cited by 299 · see citing works

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

Tao, S., Wang, S., Moghaddam, S. J., Ooi, A., Chapman, E., Wong, P. K., & Zhang, D. D. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1439 · Cited by 291 · see citing works

Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas

Fukumoto, S., Yamauchi, N., Moriguchi, H., Hippo, Y., Watanabe, A., Shibahara, J., Taniguchi, H., Ishikawa, S., Ito, H., Yamamoto, S., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1238 · Cited by 290 · see citing works

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

Takaya, K., Suzuki, T., Motohashi, H., Onodera, K., Satomi, S., Kensler, T. W., & Yamamoto, M. P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.023 · Cited by 277 · see citing works

Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling

Paul, M., Bisht, B., Darmawan, D. O., Chiou, R., Ha, V., Wallace, W., Chon, A., Hegab, A., Grogan, T., Elashoff, D., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.009 · Cited by 276 · see citing works

ChIP-nexus enables improved detection of in vivo transcription factor binding footprints

He, Q., Johnston, J., & Zeitlinger, J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3121 · Cited by 263 · see citing works

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

Wang, R., An, J., Ji, F., Jiao, H., Sun, H., & Zhou, D. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.004 · Cited by 261 · see citing works

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

Hast, B. E., Goldfarb, D., Mulvaney, K. M., Hast, M. A., Siesser, P. F., Yan, F., Hayes, D. N., & Major, M. B. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4400 · Cited by 259 · see citing works

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

Agyeman, A. S., Chaerkady, R., Shaw, P. G., Davidson, N. E., Visvanathan, K., Pandey, A., & Kensler, T. W. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1536-9 · Cited by 252 · see citing works

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

Satoh, H., Moriguchi, T., Takai, J., Ebina, M., & Yamamoto, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4499 · Cited by 251 · see citing works

Gene expression profiling of NRF2-mediated protection against oxidative injury

Cho, H., Reddy, S. P., DeBiase, A., Yamamoto, M. P., & Kleeberger, S. R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.013 · Cited by 246 · see citing works

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Pearson, K. J., Lewis, K. N., Price, N. L., Chang, J. W., Perez, E., Cascajo, M. V., Tamashiro, K. L., Poosala, S., Csiszár, A., Ungvari, Z. I., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712162105 · Cited by 238 · see citing works

Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3

An, J. H., Vranas, K. C., Lucke, M., Inoue, H., Hisamoto, N., Matsumoto, K., & Blackwell, T. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508105102 · Cited by 236 · see citing works

Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration

Wakabayashi, N., Shin, S., Slocum, S. L., Agoston, E. S., Wakabayashi, J., Kwak, M.-K., Misra, V., Biswal, S. S., Yamamoto, M. P., & Kensler, T. W. (2010) · Science Signaling · doi:10.1126/scisignal.2000762 · Cited by 224 · see citing works

Roles of Nrf2 in cell proliferation and differentiation

Murakami, S., & Motohashi, H. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.030 · Cited by 221 · see citing works

ChIP‐exo Method for Identifying Genomic Location of DNA‐Binding Proteins with Near‐Single‐Nucleotide Accuracy

Rhee, H. S., & Pugh, B. F. (2012) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2124s100 · Cited by 195 · see citing works

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Hanada, N., Takahata, T., Zhou, Q., Ye, X., Sun, R., Itoh, J., Ishiguro, A., Kijima, H., Mimura, J., Itoh, K., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-66 · Cited by 189 · see citing works

<i>CUL3</i> and <i>NRF2</i> Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

Ooi, A., Dykema, K., Ansari, A., Petillo, D., Snider, J., Kahnoski, R., Anema, J., Craig, D., Carpten, J., Teh, B.-T., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3227 · Cited by 159 · see citing works

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

Li, J., Stein, T. D., & Johnson, J. A. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00209.2003 · Cited by 154 · see citing works

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

Kovac, M. B., Navas, C., Horswell, S. D., Salm, M., Bardella, C., Rowan, A., Stares, M. D., Castro-Giner, F., Fisher, R. A., de Bruin, E. C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7336 · Cited by 122 · see citing works

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J.-H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J. B., Matsui, W. H., MacVittie, T. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70812 · Cited by 112 · see citing works

Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome

Muscarella, L. A., Barbano, R., D’Angelo, V., Copetti, M., Coco, M., Balsamo, T., la Torre, A., Notarangelo, A., Troiano, M., Parisi, S., et al. (2011) · Epigenetics · doi:10.4161/epi.6.3.14408 · Cited by 108 · see citing works

AberrantKeap1methylation in breast cancer and association with clinicopathological features

Barbano, R., Muscarella, L. A., Pasculli, B., Valori, V. M., Fontana, A., Coco, M., la Torre, A., Balsamo, T., Poeta, M. L., Marangi, G. F., et al. (2012) · Epigenetics · doi:10.4161/epi.23319 · Cited by 92 · see citing works

Mechanisms of Cell Cycle Control Revealed by a Systematic and Quantitative Overexpression Screen in S. cerevisiae

Niu, W., Li, Z., Zhan, W., Iyer, V. R., & Marcotte, E. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000120 · Cited by 74 · see citing works

The Transcriptome of Nrf2−/− Mice Provides Evidence for Impaired Cell Cycle Progression in the Development of Cigarette Smoke–Induced Emphysematous Changes

Gebel, S., Diehl, S., Pype, J. L., Friedrichs, B., Weiler, H., Schüller, J., Xu, H., Taguchi, K., Yamamoto, M. P., & Müller, T. H. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq039 · Cited by 62 · see citing works

Cy-preds: An algorithm and a web service for the analysis and prediction of cysteine reactivity

Soylu, İ., & Marino, S. M. (2015) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24978 · Cited by 41 · see citing works

Insights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas

Haake, S. M., Weyandt, J. D., & Rathmell, W. K. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0115 · Cited by 41 · see citing works

Activation of nuclear factor E2‐related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development†

Marhenke, S., Lamlé, J., Buitrago‐Molina, L. E., Cañón, J. M. F., Geffers, R., Finegold, M. J., Sporn, M. B., Yamamoto, M. P., Manns, M. P., Grompe, M., et al. (2008) · Hepatology · doi:10.1002/hep.22391 · Cited by 37 · see citing works

Loss of Nrf2 in Mice Evokes a Congenital Intrahepatic Shunt That Alters Hepatic Oxygen and Protein Expression Gradients and Toxicity

Skoko, J., Wakabayashi, N., Noda, K., Kimura, S., Tobita, K., Shigemura, N., Tsujita, T., Yamamoto, M. P., & Kensler, T. W. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu109 · Cited by 32 · see citing works

Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1)

Sandhu, I. S., Maksim, N. J., Amouzougan, E. A., Gallion, B. W., Raviele, A. L. J., & Ooi, A. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150041 · Cited by 19 · see citing works

Mapping Protein–DNA Interactions Using ChIP-exo and Illumina-Based Sequencing

Barfeld, S. J., & Mills, I. G. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3724-0_8 · Cited by 4 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

Kerins, M. J., & Ooi, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7176 · Cited by 741 · see citing works

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

Dinkova‐Kostova, A. T., Fahey, J. W., Kostov, R. V., & Kensler, T. W. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.02.002 · Cited by 286 · see citing works

Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy

Basak, P., Sadhukhan, P., Sarkar, P., & Sil, P. C. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.06.002 · Cited by 134 · see citing works

The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding

Gaćeša, R., Lawrence, K. P., Georgakopoulos, N., Yabe, K., Dunlap, W. C., Barlow, D. J., Wells, G., Young, A. R., & Long, P. F. (2018) · Biochimie · doi:10.1016/j.biochi.2018.07.020 · Cited by 83 · see citing works

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Ngo, V., Karunatilleke, N. C., Brickenden, A. M., Choy, W., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11020243 · Cited by 35 · see citing works

Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor

Kerins, M. J., Liu, P., Tian, W., Mannheim, W., Zhang, D. D., & Ooi, A. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00037-19 · Cited by 25 · see citing works

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies

Poornima, P., Kankia, I. H., Langdon, S. P., & Deeni, Y. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.57 · Cited by 23 · see citing works

Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health

Shannar, A., Chou, P. J., Peter, R. M., Dave, P. D., Patel, K., Pan, Y., Xu, J., Sarwar, M. S., & Kong, A. T. (2024) · Current Pharmacology Reports · doi:10.1007/s40495-024-00388-6 · Cited by 19 · see citing works

Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines

Skowron, M. A., Niegisch, G., Albrecht, P., van Koeveringe, G. A., Romano, A., Albers, P., Schulz, W. A., & Hoffmann, M. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081680 · Cited by 14 · see citing works

Disease Modifying Potential of Functional Foods for Neurodegenerative Disorders: Status Update on Regulatory Compliance

Thomas, C., Shilpa, B. M., & Mythri, R. B. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97546 · Cited by 8 · see citing works

The cross-talk between NRF2 and apoptosis in cancer

Beilankouhi, E. A. V., Yousefi, B., Hadian, N., Safaralizadeh, R., & Valilo, M. (2025) · Medical Molecular Morphology · doi:10.1007/s00795-025-00434-2 · Cited by 6 · see citing works

Two Faces of Nrf2 in Cancer

Yildiz, M., & Seğmen, H. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102753

Editorial overview: Nrf2 in Toxicology: An update

Johnson, J., Puga, A., Wallace, K. B., & Zhang, D. D. (2016) · Current Opinion in Toxicology · doi:10.1016/s2468-2020(16)30057-2

Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges

Torrente, L., & DeNicola, G. M. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-104025 · Cited by 168 · see citing works

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer

Kang, J.-S., Nam, L. B., Yoo, O.-K., & Keum, Y. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114002 · Cited by 34 · see citing works

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

Robertson, H., Dinkova‐Kostova, A. T., & Hayes, J. D. (2020) · Cancers · doi:10.3390/cancers12123609 · Cited by 83 · see citing works

Genetic, metabolic and immunological features of cancers with NRF2 addiction

Kitamura, H., Takeda, H., & Motohashi, H. (2022) · FEBS Letters · doi:10.1002/1873-3468.14458 · Cited by 15 · see citing works