An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
Open accessAbstract
Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (PRCC2). The main effect of FH mutation is fumarate accumulation. The current paradigm posits that the main consequence of fumarate accumulation is HIF-α stabilization. Paradoxically, FH mutation differs from other HIF-α stabilizing mutations, such as VHL and SDH mutations, in its associated tumor types. We identified that fumarate can directly up-regulate antioxidant response element (ARE)-controlled genes. We demonstrated that aldo-keto reductase family 1 member B10 (AKR1B10) is an ARE-controlled gene and is up-regulated upon FH knockdown as well as in FH null cell lines. AKR1B10 overexpression is also a prominent feature in both hereditary and sporadic PRCC2. This phenotype better explains the similarities between hereditary and sporadic PRCC2.
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High fumarate binds glutathione, augmenting ROS signaling and accumulation in vitro and in vivo.
“High concentrations of fumarate bind to glutathione, augmenting ROS signaling and accumulation, as observed in not only in vitro models but also in vivo models136,137.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [137]
Cells lacking FH have high levels of succination on KEAP1, an electrophile sensor and negative regulator of Nrf2.
“Cells lacking FH were shown to have high levels of succination on Kelch-like ECH-associated protein 1 (KEAP1), an electrophile sensor and negative regulator of the transcription factor Nuclear Factor E2-related factor 2 (Nrf2) (Adam et al., 2011; Ooi et al., 2011).”
From Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? (2012) · cites this paper as Ooi et al., 2011
TH1 and TH17 cells rely heavily on aerobic glycolysis.
“Two pro-inflammatory T cell subsets implicated in the pathogenesis of MS, namely TH1 and TH17 cells, rely heavily on aerobic glycolysis and treatment with DMF or MMF inhibited their development in vitro, as previously reported99,101,102, 49.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [101]
Treatment with DMF or MMF inhibits development of TH1 and TH17 cells in vitro.
“Two pro-inflammatory T cell subsets implicated in the pathogenesis of MS, namely TH1 and TH17 cells, rely heavily on aerobic glycolysis and treatment with DMF or MMF inhibited their development in vitro, as previously reported99,101,102, 49.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [101]
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- Authors
- Ooi, A., Wong, J.-C., Petillo, D., Roossien, D., Perrier-Trudova, V., Whitten, D., Min, B. W. H., Tan, M.-H., Zhang, Z., Yang, X. J., Zhou, M., Gardie, B., Molinié, V., Richard, S., Tan, P. H., Teh, B. T., & Furge, K. A.
- Affiliations
- Van Andel Institute (US)
- National Cancer Centre Singapore (SG)
- Michigan State University (US)
- Northwestern University (US)
- Cleveland Clinic (US)
- Inserm (FR)
- Singapore General Hospital (SG)
- Corresponding author
- Teh, Bin Tean
- Furge, Kyle A.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 20
- Issue
- 4
- Pages
- 511-523
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1976949137
- Cited by
- 401
- References
- 68
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 22 · 2023: 23 · 2022: 21 · 2021: 18 · 2020: 33 · 2019: 35 · 2018: 33 · 2017: 32 · 2016: 41 · 2015: 27 · 2014: 26 · 2013: 36 · 2012: 21
- FWCI
- 24.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Van Andel Research Institute
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- type 2 papillary renal cell carcinoma, fumarate accumulation, antioxidant response element, AKR1B10, aldo-keto reductase, tumor suppressor mutations
- MeSH terms
- Kelch-Like ECH-Associated Protein 1, Aldo-Keto Reductases, Aldehyde Reductase, Antioxidants, Carcinoma, Renal Cell, Fumarate Hydratase, Humans, Kidney Neoplasms, Phenotype, RNA, Messenger, Gene Expression Regulation, Neoplastic, Response Elements, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Nuclear Respiratory Factor 1, NF-E2-Related Factor 2, Hypoxia-Inducible Factor 1, alpha Subunit
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