On the history of oxidative stress: Concept and some aspects of current development

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Free Radicals in Biology and Medicine

Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

A Syndrome produced by Diverse Nocuous Agents

Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967

Oxidative Stress

Sies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045037 · Cited by 3,520

The human disease network

Goh, K.-I., Cusick, M. E., Valle, D., Childs, B., Vidal, M., & Barabási, A.-L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701361104 · Cited by 3,242

Oxidative stress: a concept in redox biology and medicine

Sies, H. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.002 · Cited by 3,208

Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent

Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Sies, H. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.035 · Cited by 2,148

Strategies of antioxidant defense

SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976

Redefining Oxidative Stress

Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726

Role of Quinones in Toxicology

Bolton, J. L., Trush, M. A., Penning, T. M., Dryhurst, G., & Monks, T. J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx9902082 · Cited by 1,703

Free radicals, reactive oxygen species, oxidative stress and its classification

Lushchak, V. I. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.016 · Cited by 1,665

The exposome: from concept to utility

Wild, C. P. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr236 · Cited by 1,416

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

Schreck, R., Albermann, K., & Baeuerle, P. A. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079515 · Cited by 1,388

Biochemistry of Oxidative Stress

Sies, H. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198610581 · Cited by 1,316

Oxidative Stress: Introductory Remarks

Sies, H. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-642760-8.50005-3 · Cited by 1,037

Lipid peroxidation: Physiological levels and dual biological effects

Niki, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.032 · Cited by 1,032

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

Christman, M. F., Morgan, R. W., Jacobson, F. S., & Ames, B. N. (1985) · Cell · doi:10.1016/s0092-8674(85)80056-8 · Cited by 1,029

Clinical Relevance of Biomarkers of Oxidative Stress

Frijhoff, J., Winyard, P. G., Žarković, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E., Oettrich, J., Ruskovska, T., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6317 · Cited by 918

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

Thor, H., Smith, M. T., Hartzell, P., Bellomo, G., Jewell, S. A., & Orrenius, S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33730-x · Cited by 902

Hydrogen peroxide sensing, signaling and regulation of transcription factors

Marinho, H. S., Real, C., Cyrne, L., Soares, H., & Antunes, F. (2014) · Redox Biology · doi:10.1016/j.redox.2014.02.006 · Cited by 872

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework

Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J. B., Cai, L., Nina Cedergreen, G., Cherian, M. G., Chiueh, C. C., Clarkson, T. W., et al. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.02.015 · Cited by 751

Multiphase Chemistry at the Atmosphere–Biosphere Interface Influencing Climate and Public Health in the Anthropocene

Pöschl, U., & Shiraiwa, M. (2015) · Chemical Reviews · doi:10.1021/cr500487s · Cited by 691

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

Meier, B., Radeke, H. H., Selle, S., Younes, M., Sies, H., Resch, K., & Habermehl, G. (1989) · Biochemical Journal · doi:10.1042/bj2630539 · Cited by 650

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

Kappus, H., & Sies, H. (1981) · Cellular and Molecular Life Sciences · doi:10.1007/bf01948335 · Cited by 648

The Redox Code

Jones, D. P., & Sies, H. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6247 · Cited by 647

Respiratory chain linked H2O2 production in pigeon heart mitochondria

Loschen, G., & Flohé, L. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80459-3 · Cited by 552

Oxidative stress: damage to intact cells and organs

Sies, H., & Cadenas, E. (1985) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1985.0168 · Cited by 551

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

Wondrak, G. T. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2541 · Cited by 462

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

Suzuki, T., & Yamamoto, M. P. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.800169 · Cited by 412

Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide

R. Buettner, G. (2011) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152011795677544 · Cited by 374

The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine

Cortese-Krott, M. M., Koning, A. M., Kuhnle, G., Nagy, P., Bianco, C. L., Pasch, A., Wink, D. A., Fukuto, J. M., Jackson, A. A., van Goor, H., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7083 · Cited by 371

Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution

Niemann, B., Rohrbach, S., Miller, M. R., Newby, D. E., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.043 · Cited by 364

The cysteine proteome

Go, Y., Chandler, J. D., & Jones, D. P. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.022 · Cited by 363

Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health

Kehrer, J. P., & Klotz, L. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1074159 · Cited by 359

Enzymatic activation of chemicals to toxic metabolites

Guengerich, F. P., Liebler, D. C., & Reed, D. L. (1985) · Critical Reviews in Toxicology · doi:10.3109/10408448509037460 · Cited by 335

Dissecting Redox Biology Using Fluorescent Protein Sensors

Schwarzländer, M., Dick, T. P., Meyer, A. J., & Morgan, B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6266 · Cited by 310

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

Münzel, T. F., Daiber, A., Steven, S., Tran, L. P., Ullmann, E., Kossmann, S., Schmidt, F. P., Oelze, M. W., Xia, N., Li, H., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx081 · Cited by 292

Nutritional Metabolomics: Progress in Addressing Complexity in Diet and Health

Jones, D. P., Park, Y. H., & Ziegler, T. R. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145159 · Cited by 265

Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer

Hrycay, E. G., & Bandiera, S. M. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.03.003 · Cited by 234

Oxidative stress and antioxidants: Distress or eustress?

Niki, E. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.017 · Cited by 209

The oxidative stress theory of disease: levels of evidence and epistemological aspects

Ghezzi, P., Jaquet, V., Marcucci, F., & Schmidt, H. H. H. W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13544 · Cited by 191

Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide

Thomas, D. D. (2015) · Redox Biology · doi:10.1016/j.redox.2015.05.002 · Cited by 179

Redox theory of aging: implications for health and disease

Go, Y., & Jones, D. P. (2017) · Clinical Science · doi:10.1042/cs20160897 · Cited by 179

Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase

Olson, K. R., Gao, Y., Arif, F., Arora, K., Patel, S., DeLeon, E. R., Sutton, T. R., Feelisch, M., Cortese-Krott, M. M., & Straub, K. D. (2017) · Redox Biology · doi:10.1016/j.redox.2017.11.009 · Cited by 178

The emerging challenge in diabetes: The “metabolic memory”

Ceriello, A. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.05.005 · Cited by 177

Positive oxidative stress in aging and aging-related disease tolerance

Yan, L. (2014) · Redox Biology · doi:10.1016/j.redox.2014.01.002 · Cited by 176

Role of oxidative stress in cardiovascular disease outcomes following exposure to ambient air pollution

Kelly, F. J., & Fussell, J. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.019 · Cited by 171

The steady state level of catalase compound I in isolated hemoglobin‐free perfused rat liver

Sies, H., & Chance, B. (1970) · FEBS Letters · doi:10.1016/0014-5793(70)80521-x · Cited by 169

Air Pollution Stress and the Aging Phenotype: The Telomere Connection

Martens, D. S., & Nawrot, T. S. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0098-8 · Cited by 132

HyPer Family Probes: State of the Art

Bilan, D. S., & Belousov, V. V. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6586 · Cited by 124

Glutathione metabolism of the red cells effect of glutathione reductase deficiency on the stimulation of hexose monophosphate shunt under oxidative stress

Paniker, N. V., Srivastava, S. K., & Beutler, E. (1970) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(70)90096-6 · Cited by 87

Redox biology: Interface of the exposome with the proteome, epigenome and genome

Go, Y., & Jones, D. P. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.032 · Cited by 76

Organizers and activators: Cytosolic Nox proteins impacting on vascular function

Schröder, K., Weißmann, N., & Brandes, R. P. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.03.017 · Cited by 74

Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling

Kirkpatrick, D. L., & Powis, G. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6633 · Cited by 57

Oxidative Stress: A Unifying Mechanism for Cell Damage Induced by Noise, (Water-Pipe) Smoking, and Emotional Stress— Therapeutic Strategies Targeting Redox Imbalance

Golbidi, S., Li, H., & Laher, I. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7257 · Cited by 54

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging

Golubev, A. G., Hanson, A. D., & Gladyshev, V. N. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7105 · Cited by 43

Oxidative Stress1

Sies, H., & Jones, D. P. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6/00285-3 · Cited by 39

“The dose makes the poison”: Key implications for mode of action (mechanistic) research in a 21st century toxicology paradigm

Bus, J. S. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.06.013 · Cited by 36

Mithridates VI Eupator, father of the empirical toxicology

Valle, G., Stanislao, M., Facciorusso, A., Carmignani, M., & Volpe, A. R. (2009) · Clinical Toxicology · doi:10.1080/15563650902899144 · Cited by 19

Oxidative Stress Relaxation of Natural Rubber Vulcanized with Di-Tertiary-Butyl Peroxide

Ore, S. (1956) · Rubber Chemistry and Technology · doi:10.5254/1.3542575 · Cited by 10

A Historical Perspective on Oxidative Stress and Intracellular Redox Control

Estevam, E. C., Nasim, M. J., Faulstich, L., Hakenesch, M., Burkholz, T., & Jacob, C. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-19096-9_1 · Cited by 6

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638

The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview

Dumanovic, J., Nepovimová, E., Natić, M., Kuča, K., & Jacevic, V. M. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2020.552969 · Cited by 1,023

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Pisoschi, A. M., Pop, A., Iordache, F., Stanca, L., Predoi, G., & Șerban, A. I. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112891 · Cited by 883

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Surai, P. F., Kochish, I. I., Fisinin, V. I., & Kidd, M. T. (2019) · Antioxidants · doi:10.3390/antiox8070235 · Cited by 721

Oxidative Stress: Concept and Some Practical Aspects

Sies, H. (2020) · Antioxidants · doi:10.3390/antiox9090852 · Cited by 652

Oxidative Stress

Sies, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813146-6.00013-8 · Cited by 100

Oxidative eustress and oxidative distress: Introductory remarks

Sies, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00001-8 · Cited by 59

Introduction to serial reviews on redox signaling in immune function and cellular responses in lung injury and diseases

Mantell, L. L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.014 · Cited by 2

Foreword

Crawford, M. H. (1987) · Current Problems in Cardiology · doi:10.1016/0146-2806(87)90001-6

The Evolving Concept of Oxidative Stress

Fernandes, D. D. C., Bonatto, D., & Laurindo, F. R. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_1 · Cited by 8