Respiratory chain linked H2O2 production in pigeon heart mitochondria
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Although nonmitochondrial sources of ROS exist during ischemia, the majority of ROS are likely derived from the mitochondrial respiratory complexes.
“Although nonmitochondrial sources of ROS exist during ischemia [e.g., NAD(P)H oxidase (141, 188, 328) and xanthine oxidase (25) in vasculature], the majority of ROS are likely derived from the mitochondrial respiratory complexes, as shown by the damage to respiratory complexes (212, 213, 245) and the effect of mitochondrial inhibitors (5, 28, 71, 81–86).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [212]
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- Authors
- Loschen, G., & Flohé, L.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Flohé, L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1971-11
- Volume
- 18
- Issue
- 2
- Pages
- 261-264
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2086896843
- Cited by
- 552
- References
- 13
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 16 · 2021: 16 · 2020: 15 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 13 · 2015: 21 · 2014: 21 · 2013: 16 · 2012: 16
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- hydrogen peroxide production, electron transport chain, heart mitochondria, pigeons, reactive oxygen species, mitochondrial respiration
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