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Cell-to-cell transmission of viruses
Open accessAbstract
The life cycle of most viruses involves the release of particles into the extracellular space. Consequently, the study of virus egress as well as virus entry has focused almost exclusively on the biology of cell-free virus. However, cell-free virus spread is often very inefficient. Specific barriers, either located in the donor cell or in the target cell, prevent efficient spread by the cell-free mode. In contrast, viral spread by direct cell-cell contact is largely unaffected by most of these barriers resulting in preferential spread by cell-to-cell transmission. Virus cell-to-cell transmission allows an efficient coordination of several steps of the viral life cycle. It often involves complex inter-cellular adhesion, cellular polarity and intra-cellular trafficking. Because virus cell-to-cell transmission can involve transmission through zones of tight cell-cell contact that are resistant to neutralizing antibodies and reach a high local particle concentration, cell-to-cell transmission can contribute to the pathogenesis of viral infections.
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“Cell-to-cell transmission is one of the strategies adopted by several viruses to overcome host barriers and to establish successful infection”
From Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells (2020) · cites this paper as Zhong et al., 2013
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Marsh, M., & Helenius, A. (2006) · Cell · doi:10.1016/j.cell.2006.02.007 · Cited by 1,209
Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton
Igakura, T., Stinchcombe, J. C., Goon, P. K. C., Taylor, G. P., Weber, J. N., Griffiths, G. M., Tanaka, Y., Osame, M., & Bangham, C. R. M. (2003) · Science · doi:10.1126/science.1080115 · Cited by 755
Sowinski, S., Jolly, C., Berninghausen, O., Purbhoo, M. A., Chauveau, A., Köhler, K., Oddos, S., Eissmann, P., Brodsky, F. M., Hopkins, C., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1682 · Cited by 754
Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
McDonald, D., Wu, L., Bohks, S. M., KewalRamani, V. N., Unutmaz, D., & Hope, T. J. (2003) · Science · doi:10.1126/science.1084238 · Cited by 707
HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes
Miyauchi, K., Kim, Y., Latinovic, O., Va, M., & Melikyan, G. B. (2009) · Cell · doi:10.1016/j.cell.2009.02.046 · Cited by 682
Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding
O’Doherty, U., Swiggard, W. J., & Malim, M. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.21.10074-10080.2000 · Cited by 669
HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse
Jolly, C., Kashefi, K., Hollinshead, M., & Sattentau, Q. J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030648 · Cited by 623
Avoiding the void: Cell-to-cell spread of human viruses
Sattentau, Q. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1972 · Cited by 614
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
Sigal, A., Kim, J. T., Balazs, A. B., Dekel, E., Mayo, A., Milo, R., & Baltimore, D. (2011) · Nature · doi:10.1038/nature10347 · Cited by 538
Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells
van der Schaar, H. M., Rust, M. J., Chen, C., van der Ende-Metselaar, H. H., Wilschut, J., Zhuang, X., & Smit, J. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000244 · Cited by 490
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- Mazurov, 2011, The role of O-glycosylation and expression of CD43 and CD45 on the surface of effector T cells in HTLV-1 cell-to-cell infection, J Virol
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Mondal, C., Adak, D., & Bairagi, N. (2022) · Springer eBooks · doi:10.1007/978-3-031-12515-7_6 · Cited by 1
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Ssenyange, G., Kerfoot, M., Zhao, M., Farhadian, S., Chen, S., Peng, L., Ren, P., Cruz, C. S. D., Gupta, S., & Sutton, R. E. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100252 · Cited by 2
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Megremis, S., Walker, T. D. J., He, X. T., O’Sullivan, J., Ollier, W., Chinoy, H., Pendleton, N., Payton, A., Hampson, L., HAMPSON, I. N., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.25.007534 · Cited by 1
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Lawrence, S. P., Elser, S. E., Torben, W., Blair, R. V., Pahar, B., Aye, P. P., Schiro, F. R., Szeltner, D. M., Doyle‐Meyers, L. A., Haggarty, B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.31.437834 · Cited by 1
HIV-1-induced cell-cell fusion: Host regulation and consequences for viral spread
Symeonides, M. (2016) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Miao, C. (2016) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/57242
Espy, N. (2017) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
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Dutta, H., & Phukan, J. (2023) · Physica Scripta · doi:10.1088/1402-4896/ad0343
Karimi, M. I. E., Hattaf, K., & Yousfi, N. (2024) · Journal of Mathematics and Computer Science · doi:10.22436/jmcs.034.01.02
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Amarbayasgalan, S., Takahashi, T., Sugiura, Y., Shimizu, K., Dorjsuren, E., Luo, L., & Kamitani, W. (2026) · Journal of General Virology · doi:10.1099/jgv.0.002241
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Bolland, W. (2024) · theses.fr (ABES) · doi:10.70675/37becb05zce46z4760z8c80zee5762b9dcea
Ymele, J. D., & Yemélé, D. (2026) · Results in Control and Optimization · doi:10.1016/j.rico.2026.100771
이, 민., Choi, C.-H., Lee, S. E., Kim, J.-W., Sim, G., Lee, J. H., Yi, H., & Chung, Y.-S. (2026) · Emerging Microbes & Infections · doi:10.1080/22221751.2026.2746255
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Mukai, K., Jia, D., Panigrahi, M., Tayman, T., Brogden, G., Chen, Y.-H., Haque, N., Arora, G., Mutterperl, J. E., Poe, I., et al. (2026) · Cell · doi:10.1016/j.cell.2026.10.004
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Metadata
- Authors
- Zhong, P., Agosto, L. M., Munro, J. B., & Mothes, W.
- Affiliations
- Yale University (US)
- Corresponding author
- Mothes, Walther
- Venue
- Current Opinion in Virology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 3
- Issue
- 1
- Pages
- 44-50
- ISSN
- 1879-6257 (ISSN-L)
- PMC
- PMC3587356
- OpenAlex
- W1966635724
- Cited by
- 231
- References
- 69
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 19 · 2023: 22 · 2022: 11 · 2021: 30 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 15 · 2016: 15 · 2015: 13 · 2014: 19 · 2013: 6
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Virology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research Institute
- Yale University
- China Scholarship Council
- National Institutes of Health
- National Cancer Institute (R01CA098727)
- National Institute of Allergy and Infectious Diseases (R01AI084096)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- cell-to-cell transmission, viral egress, viral entry, viral life cycle, cell-cell adhesion, cell polarity, intracellular trafficking, neutralizing antibodies, viral pathogenesis, viral spread
- MeSH terms
- Animals, Cell Adhesion, HIV, Humans, Models, Biological, Vaccinia virus, Virus Internalization, Virus Release
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