The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Cell-to-cell transmission of viruses
Open accessAbstract
The life cycle of most viruses involves the release of particles into the extracellular space. Consequently, the study of virus egress as well as virus entry has focused almost exclusively on the biology of cell-free virus. However, cell-free virus spread is often very inefficient. Specific barriers, either located in the donor cell or in the target cell, prevent efficient spread by the cell-free mode. In contrast, viral spread by direct cell-cell contact is largely unaffected by most of these barriers resulting in preferential spread by cell-to-cell transmission. Virus cell-to-cell transmission allows an efficient coordination of several steps of the viral life cycle. It often involves complex inter-cellular adhesion, cellular polarity and intra-cellular trafficking. Because virus cell-to-cell transmission can involve transmission through zones of tight cell-cell contact that are resistant to neutralizing antibodies and reach a high local particle concentration, cell-to-cell transmission can contribute to the pathogenesis of viral infections.
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“Cell-to-cell transmission is one of the strategies adopted by several viruses to overcome host barriers and to establish successful infection”
From Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells (2020) · cites this paper as Zhong et al., 2013
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Cites
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van Riel, D., Verdijk, R., & Kuiken, T. (2015) · The Journal of Pathology · doi:10.1002/path.4461 · Cited by 394
Receptors and routes of dengue virus entry into the host cells
Cruz-Oliveira, C., Freire, J. M., Conceição, T. M., Higa, L. M., Castanho, M. A. R. B., & Poian, A. T. D. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuu004 · Cited by 340
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Metadata
- Authors
- Zhong, P., Agosto, L. M., Munro, J. B., & Mothes, W.
- Affiliations
- Yale University (US)
- Corresponding author
- Mothes, Walther
- Venue
- Current Opinion in Virology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 3
- Issue
- 1
- Pages
- 44-50
- ISSN
- 1879-6257 (ISSN-L)
- PMC
- PMC3587356
- OpenAlex
- W1966635724
- Cited by
- 231
- References
- 69
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 19 · 2023: 22 · 2022: 11 · 2021: 30 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 15 · 2016: 15 · 2015: 13 · 2014: 19 · 2013: 6
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Virology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research Institute
- Yale University
- China Scholarship Council
- National Institutes of Health
- National Cancer Institute (R01CA098727)
- National Institute of Allergy and Infectious Diseases (R01AI084096)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- cell-to-cell transmission, viral egress, viral entry, viral life cycle, cell-cell adhesion, cell polarity, intracellular trafficking, neutralizing antibodies, viral pathogenesis, viral spread
- MeSH terms
- Animals, Cell Adhesion, HIV, Humans, Models, Biological, Vaccinia virus, Virus Internalization, Virus Release
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