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A review of opioid dependence treatment: Pharmacological and psychosocial interventions to treat opioid addiction
Abstract
Opioid dependence is a problem of national concern, especially with dramatically increased rates of abuse and dependence of prescription opioids. The current article provides an up-to-date review of the literature on opioid dependence treatment, with a focus on conclusions drawn by experts in the field (e.g., Cochrane reviews and meta-analyses) and methodologically rigorous studies (e.g., randomized controlled trials). We describe the major classes of drug treatments available, including opioid agonist (e.g., methadone, buprenorphine, LAAM), antagonist (e.g., naltrexone) and non-opioid pharmacotherapies (e.g., alpha2 adrenergic agonists). These treatments are discussed in the context of detoxification and long term treatment options such as abstinence-based and maintenance strategies. We review the state of the literature as to prevention of opioid overdose and discuss the widespread problem of comorbidity among opioid-dependent populations. We also focus prominently on evidence for inclusion of psychosocial approaches in treatment regimens, either as stand-alone or in conjunction with psychopharmacological options.
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“There is a dearth of research investigating the efficacy of psychosocial treatments in reducing opioid use among people living with chronic pain.42,43”
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Metadata
- Authors
- Veilleux, J. C., Colvin, P. J., Anderson, J., York, C., & Heinz, A. J.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Veilleux, Jennifer C.
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 30
- Issue
- 2
- Pages
- 155-166
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W2038833041
- Cited by
- 336
- References
- 130
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 11 · 2023: 13 · 2022: 21 · 2021: 12 · 2020: 24 · 2019: 62 · 2018: 24 · 2017: 22 · 2016: 18 · 2015: 24 · 2014: 29 · 2013: 22 · 2012: 20
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- opioid use disorder, opioid dependence treatment, pharmacological interventions, psychosocial interventions, methadone, buprenorphine, LAAM, naltrexone, alpha-2 adrenergic agonists, opioid agonists, opioid antagonists, opioid detoxification, abstinence-based treatment, maintenance therapy, opioid overdose prevention, comorbidities, prescription opioid abuse
- MeSH terms
- Biofeedback, Psychology, Humans, Narcotic Antagonists, Opioid-Related Disorders, Narcotics, Self-Help Groups, Cognitive Behavioral Therapy, Prevalence, Adrenergic Agents
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