Cited by 179Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPersonality Disorders and PsychopathologyPsychotherapy Techniques and Applications

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A systematic review of Unified Protocol applications with adult populations: Facilitating widespread dissemination via adaptability

Cassiello-Robbins, Clair, Southward, Matthew W., Tirpak, Julianne Wilner, Sauer-Zavala, Shannon·2020·Clinical Psychology Review

DOI 10.1016/j.cpr.2020.101852

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Abstract

The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) was designed to be a flexible, evidence-based intervention that could treat a wide range of emotional disorders. The purpose of this systematic review is to summarize (1) the range of presenting problems to which the UP has been applied with adult patients, and (2) the settings in which the protocol has been used, as well as any modifications made to it. Using PRISMA guidelines, we conducted a literature search of PsychInfo, PubMed, Proquest Dissertations and Theses, and Web of Science. The 77 studies included in this review indicated the UP has been applied to a wide range of presenting problems including anxiety, depressive, bipolar, traumatic-stressor, substance use, eating, borderline personality, insomnia, and physical health disorders. Additionally, the UP has been applied to non-diagnosable problems such as non-suicidal self-injury, subclinical presentations, and sexual minority stress. The strongest base of evidence for the UP is among Caucasian females in the United States with anxiety-related or depressive disorders. Numerous adaptions of the UP were present in the literature. Overall, results suggest the UP can be flexibly applied to a range of diagnostic presentations. However, many studies reviewed were preliminary and further research is needed.

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Optimizing Outcomes in Psychotherapy for Anxiety Disorders (OPTIMAX) Protocol– A Randomized Controlled Trial on Efficacy and Response Prediction in a Transdiagnostic Psychotherapy Treatment for Anxiety DisordersPreprint
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Authors: Cassiello-Robbins, C., Southward, M. W., Tirpak, J. W., & Sauer-Zavala, S.
Affiliations: Duke Medical Center (US)
University of Kentucky (US)
Corresponding author: Cassiello-Robbins, Clair
ORCID: Southward, Matthew W.
Sauer-Zavala, Shannon
Venue: Clinical Psychology Review
Publisher: Elsevier BV
Published: 2020-06
Volume: 78
Pages: 101852
ISSN: 0272-7358 (ISSN-L)
DOI: 10.1016/j.cpr.2020.101852
OpenAlex: W3018886528
Cited by: 179
References: 59
Citations by year: 2026: 21 · 2025: 26 · 2024: 30 · 2023: 40 · 2022: 32 · 2021: 24 · 2020: 5
FWCI: 3.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Psychology Review (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: Unified Protocol, transdiagnostic treatment, emotional disorders, adults, dissemination, intervention adaptability, anxiety disorders, depression, bipolar disorder, trauma, substance use disorders, eating disorders, borderline personality disorder, insomnia, non-suicidal self-injury, sexual minority stress, treatment setting
MeSH terms: Affective Symptoms, Mental Disorders, Clinical Protocols, Humans, Outcome and Process Assessment, Health Care, Psychotherapy, Evidence-Based Practice

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A systematic review of Unified Protocol applications with adult populations: Facilitating widespread dissemination via adaptability

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