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A Novel Requirement for C. elegans Alix/ALX-1 in RME-1-Mediated Membrane Transport

Shi, Anbing, Pant, Saumya, Balklava, Zita, Chen, Carlos Chih-Hsiung, Figueroa, Vanesa, Grant, Barth D.·2007·Current Biology
DOI 10.1016/j.cub.2007.10.045
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Abstract

Background Alix/Bro1p family proteins have recently been identified as important components of multivesicular endosomes (MVEs) and are involved in the sorting of endocytosed integral membrane proteins, interacting with components of the ESCRT complex, the unconventional phospholipid LBPA, and other known endocytosis regulators. During infection, Alix can be co-opted by enveloped retroviruses, including HIV, providing an important function during virus budding from the plasma membrane. In addition, Alix is associated with the actin cytoskeleton and might regulate cytoskeletal dynamics. Results Here we demonstrate a novel physical interaction between the only apparent Alix/Bro1p family protein in C. elegans, ALX-1, and a key regulator of receptor recycling from endosomes to the plasma membrane, called RME-1. The analysis of alx-1 mutants indicates that ALX-1 is required for the endocytic recycling of specific basolateral cargo in the C. elegans intestine, a pathway previously defined by the analysis of rme-1 mutants. The expression of truncated human Alix in HeLa cells disrupts the recycling of major histocompatibility complex class I, a known Ehd1/RME-1-dependent transport step, suggesting the phylogenetic conservation of this function. We show that the interaction of ALX-1 with RME-1 in C. elegans, mediated by RME-1/YPSL and ALX-1/NPF motifs, is required for this recycling process. In the C. elegans intestine, ALX-1 localizes to both recycling endosomes and MVEs, but the ALX-…

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Metadata

Authors
Shi, A., Pant, S., Balklava, Z., Chen, C. C.-H., Figueroa, V., & Grant, B. D.
Venue
Current Biology
Publisher
Elsevier BV
Published
2007-11
Volume
17
Issue
22
Pages
1913-1924
ISSN
0960-9822
DOI
10.1016/j.cub.2007.10.045
Cited by
64
References
3
Language
en
Licence
Funders
National Institutes of Health (GM67237)

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