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Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

Lin, Sharron X., Grant, Barth, Hirsh, David, Maxfield, Frederick R.·2001·Nature Cell Biology
DOI 10.1038/35078543
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Abstract

RME-1 is an Eps15-homology (EH)-domain protein that was identified in a genetic screen for endocytosis genes in Caenorhabditis elegans. When expressed in a CHO cell line, the worm RME-1 protein and a mouse homologue are both associated with the endocytic recycling compartment. Here we show that expression of a dominant-negative construct with a point mutation near the EH domain results in redistribution of the endocytic recycling compartment and slowing down of transferrin receptor recycling. The delivery of a TGN38 chimaeric protein to the trans-Golgi network is also slowed down. The function of Rme-1 in endocytic recycling is evolutionarily conserved in metazoans as shown by the protein's properties in C. elegans.

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  • EHD1 plays a critical role in recycling of plasma membrane receptors (e.g., transferrin) internalized through clathrin-coated pits or independently of clathrin.

    “EHD1 [14] has been found to play a critical role in the recycling of plasma membrane receptors (ie., transferrin) that are internalized either through clathrin-coated pits [15-17], or independently of clathrin (MHC-I or β1 integrins) [18,19].”

    From EHD1 regulates cholesterol homeostasis and lipid droplet storage (2007) · cites this paper as [19]

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Research works printed but not linked: 37

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Metadata

Authors
Lin, S. X., Grant, B., Hirsh, D., & Maxfield, F. R.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2001-05-14
Volume
3
Issue
6
Pages
567-572
ISSN
  • 1465-7392
  • 1476-4679
DOI
10.1038/35078543
Cited by
226
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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