The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Protein Synthesis during Sleep Consolidates Cortical Plasticity In Vivo
Open accessAbstract
Sleep consolidates experience-dependent brain plasticity, but the precise cellular mechanisms mediating this process are unknown [1]. De novo cortical protein synthesis is one possible mechanism. In support of this hypothesis, sleep is associated with increased brain protein synthesis [2, 3] and transcription of messenger RNAs (mRNAs) involved in protein synthesis regulation [4, 5]. Protein synthesis in turn is critical for memory consolidation and persistent forms of plasticity in vitro and in vivo [6, 7]. However, it is unknown whether cortical protein synthesis in sleep serves similar functions. We investigated the role of protein synthesis in the sleep-dependent consolidation of a classic form of cortical plasticity in vivo (ocular dominance plasticity, ODP; [8, 9]) in the cat visual cortex. We show that intracortical inhibition of mammalian target of rapamycin (mTOR)-dependent protein synthesis during sleep abolishes consolidation but has no effect on plasticity induced during wakefulness. Sleep also promotes phosphorylation of protein synthesis regulators (i.e., 4E-BP1 and eEF2) and the translation (but not transcription) of key plasticity related mRNAs (ARC and BDNF). These findings show that sleep promotes cortical mRNA translation. Interruption of this process has functional consequences, because it abolishes the consolidation of experience in the cortex.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, phosphorylation of regulators of protein synthesis as well as translation of plasticity-related mRNAs (e.g., Arc and BDNF) was increased during sleep, overall speaking for the notion that sleep is a period of enhanced protein synthesis in these networks.”
From About Sleep's Role in Memory (2013) · cites this paper as [1060]
The cited source says what the claim attributes to it.
In the citing paper
“Rapamycin had no effect on plasticity induced during wakefulness.”
From About Sleep's Role in Memory (2013) · cites this paper as [1060]
The cited source says what the claim attributes to it.
In the citing paper
“Most recently, Seibt et al. (1060) demonstrated the critical dependence of ODP on protein synthesis during sleep, as respective plastic changes in visual cortex could be prevented by inhibition of mTOR-mediated protein synthesis through rapamycin.”
From About Sleep's Role in Memory (2013) · cites this paper as [1060]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365
Wiesel, T. N., & Hubel, D. H. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.6.1029 · Cited by 1,598
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128
Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862
A simple role for BDNF in learning and memory?
Cunha, C. (2010) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2010 · Cited by 830
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
Hresko, R. C., & Mueckler, M. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508361200 · Cited by 642
Extensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–165 of 165
Raven, F., Vega-Medina, A., Schmidt, K., He, A., Vankampen, A. A., Balendran, V., & Aton, S. J. (2025) · SLEEP · doi:10.1093/sleep/zsaf064 · Cited by 12
Self-citationProbing pathways by which rhynchophylline modifies sleep using spatial transcriptomics
Roig, M. N. B., Leduc, T., Dufort‐Gervais, J., Maghmoul, Y., Tastet, O., & Mongrain, V. (2023) · Biology Direct · doi:10.1186/s13062-023-00377-7 · Cited by 11
Hacking the functions of sleep: noninvasive approaches to stimulate sleep neurophysiology
Krugliakova, E., Breuer, F., Adelhöfer, N., Alonso, A., Besedovsky, L., Murphy, K. R., Peters, E., Raczek, K., Rasch, B., Salvesen, L., et al. (2025) · Physiological Reviews · doi:10.1152/physrev.00007.2025 · Cited by 21
Sleep Consolidation Potentiates Sensorimotor Adaptation
Solano, A., Lerner, G., Griffa, G., Deleglise, Á., Caffaro, P., Riquelme, L. A., Pérez-Chada, D., & Della‐Maggiore, V. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0325-24.2024 · Cited by 9
Neural Stimulation Has a Long-Term Effect on Foreign Vocabulary Acquisition
Pasqualotto, A., Kobanbay, B., & Proulx, M. J. (2015) · Neural Plasticity · doi:10.1155/2015/671705 · Cited by 10
Renormalizing synapses in sleep: The clock is ticking
Frank, M. G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114533 · Cited by 11
Self-citationHuman blood serum proteome changes after 6 hours of sleep deprivation at night
Bjørkum, A. A., Durán, A. C., Berven, F. S., Roy, D. S., Rosendahl, K., Birkeland, E., & Stuhr, L. E. B. (2021) · Sleep Science and Practice · doi:10.1186/s41606-021-00066-2 · Cited by 10
Moorjani, S., Walvekar, S., Fetz, E. E., & Perlmutter, S. I. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116321119 · Cited by 9
Martinez, J. D., Donnelly, M. J., Popke, D. S., Torres, D., Wilson, L. G., Brancaleone, W. P., Sheskey, S., Lin, C., Clawson, B. C., Jiang, S., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04798-y · Cited by 9
Self-citationSleep-Wake and Cortical Synaptic Plasticity
Timofeev, I., & Chauvette, S. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00029-3 · Cited by 8
Picchioni, D., Schmidt, K., McWhirter, K. K., Loutaev, I., Pavletic, A. J., Speer, A. M., Zametkin, A. J., Miao, N., Bishu, S., Turetsky, K. M., et al. (2018) · SLEEP · doi:10.1093/sleep/zsy088 · Cited by 8
Coulson, R. L., Mourrain, P., & Wang, G. X. (2024) · Journal of Comparative Physiology B · doi:10.1007/s00360-023-01531-3 · Cited by 7
Clocking in: a circadian model of synaptic plasticity
Frank, M. G. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.014 · Cited by 6
Self-citationInteractions between sleep disruption, motor learning, and p70 S6 kinase 1 signaling
Kam, K., Kang, M., Eren, C. Y., Pettibone, W. D., Bowling, H. L., Taveras, S., Ly, A., Chen, R. K., Berryman, N. V., Klann, E., et al. (2019) · SLEEP · doi:10.1093/sleep/zsz244 · Cited by 7
Rachalski, A., Freyburger, M., & Mongrain, V. (2014) · Annals of Medicine · doi:10.3109/07853890.2013.866439 · Cited by 6
Sleep, Synaptic Plasticity, and Memory
Golbert, D. C. F., Souza, A. C., Filho, D. A., & Ribeiro, S. T. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21118-8 · Cited by 5
Shaffery, J. P. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00027-x · Cited by 5
Restoration of locus coeruleus noradrenergic transmission during sleepPreprint
Sima, J., Zhang, Y., Farriday, D., Ahn, A. Y.-E., Lopez, E. R., Jin, C., Harrell, J., Darmohray, D. M., Silverman, D., & Dan, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.03.601820 · Cited by 5
A comprehensive model for the converging biologies that underpin the homeostatic sleep signal
Fernandez, F., & Grandner, M. A. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106723 · Cited by 4
Picchioni, D., Schmidt, K., Loutaev, I., Pavletic, A. J., Sheeler, C. A., Bishu, S., Balkin, T. J., & Smith, C. B. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221121873 · Cited by 4
Sleep and plasticity: Waking from a fevered dream
Frank, M. G., & Seibt, J. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.12.006 · Cited by 5
Self-citationVadakkan, K. I. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.05.001 · Cited by 4
Frank, M. G. (2019) · Springer eBooks · doi:10.1007/978-981-13-2814-5_5 · Cited by 5
Self-citationThe sleep-deprived hippocampus: a loss in translation
Wisor, J. P. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00156.2012 · Cited by 4
Slow-wave sleep : generation and propagation of slow waves, role in long-term plasticity and gating
Chauvette, S. (2013) · Corpus Université Laval (Université Laval) · Cited by 4
Neuronal Activity-Dependent Accumulation of Arc in AstrocytesPreprint
Jiang, Y., & VanDongen, A. M. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.10.376756 · Cited by 4
Cellular Mechanisms of Thalamocortical Oscillations in the Sleeping Brain
Timofeev, I., Bonjean, M., & Bazhenov, M. (2020) · Springer eBooks · doi:10.1007/978-1-0716-0653-7_5 · Cited by 4
Plasticity in the Visual Cortex
Daw, N. W. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9059-3_12 · Cited by 3
The Role of Glia in Sleep-Wake Regulation and Function
Frank, M. G. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00013-x · Cited by 3
Self-citationMongrain, V., Frank, M. G., & Leduc, T. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00045-1 · Cited by 4
Self-citationGrønli, J., Schmidt, M. A., & Wisor, J. P. (2018) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00036 · Cited by 2
Are there roles for heterogeneous ribosomes during sleep in the rodent brain?
Buchanan, I. M., Smith, T., Gerber, A. P., & Seibt, J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1008921 · Cited by 2
Self-citationSrinivasan, B., Samaddar, S., Mylavarapu, S. V. S., Clement, J. P., & Banerjee, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.01.020164 · Cited by 2
Nowacka, A., Śniegocki, M., Bożiłow, D., & Ziółkowska, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110766 · Cited by 2
Norman, H., Cortese, D., Munson, A. A., Lindström, J., & Killen, S. S. (2026) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70133 · Cited by 1
Sleep and long-term memory storage
Choi, J. H. K., & Abel, T. G. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.022 · Cited by 1
What Are the Emerging Therapeutic Uses of Bright Light Therapy For Neurological Disorders?
Weber, M., & Killgore, W. D. S. (2013) · Future Neurology · doi:10.2217/fnl.13.33 · Cited by 1
Borroto-Escuela, D. Y., Ramos, I. H., Fuxé, K., & Borroto‐Escuela, D. O. (2018) · Neuromethods · doi:10.1007/978-1-4939-8985-0_12 · Cited by 1
Analyses structurales et fonctionnelles des interactions entre elF4E et ses partenaires
Gosselin, P. (2012) · HAL
THE PUZZLE OF DECREASED HOMEOSTATIC SLOW WAVE SLEEP IN AGING
Rytkönen, K.-M. (2012) · Työväentutkimus Vuosikirja
Sleepphysiology and homeostasis
Shaw, P. J., Tafti, M., & Thorpy, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.016
Seibt, J., & Frank, M. G. (2012)
Self-citationDoes Sleep Play a Role in the Consolidation of Novelty- or Curiosity-Driven Memory Enhancement?
Stare, C. (2017) · UA Campus Repository (The University of Arizona)
Seigneur, J. (2013) · Corpus Université Laval (Université Laval)
Hartnell, I. J. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
Wu, Y. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7601
Delorme, J. E., Kuhn, F. R., Wang, L., Kodoth, V., Ma, J., Jiang, S., & Aton, S. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.02.233080
Self-citationThe Role of Sleep in Retention and Generalization of Statistically Learned Language
Sweeney, L. (2020) · UA Campus Repository (The University of Arizona)
Spindola, A. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.87.2019.tde-15052020-152022
Martinez, J. D., Donnelly, M. J., Popke, D. S., Torres, D., Wilson, L. G., Brancaleone, W. P., Clawson, B. C., Jiang, S., & Aton, S. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.25.477697
Self-citation(2017) · Wiley eBooks · doi:10.1002/9781119183839.refs
Frank, M. G. (2022) · Translational medicine research · doi:10.1007/978-94-024-2168-2_4
Self-citationSantos, J. C. A., Petsidou, E., Saraogi, P., Bartsch, U., Gerber, A. P., & Seibt, J. (2023) · Cells · doi:10.3390/cells12182320
Self-citationLatent mechanisms of plasticity are upregulated during sleep
Menarchek, B. J., & Bridi, M. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103029
Habib, S. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30004-2.00001-8
Additional file 1 of Human blood serum proteome changes after 6 hours of sleep deprivation at night
Bjørkum, A. A., Durán, A. C., Frode, B., Sinha Roy, D., Rosendahl, K., Birkeland, E., & Stuhr, L. E. B. (2021) · Figshare · doi:10.6084/m9.figshare.16680261
Roig, M. N. B., Leduc, T., Dufort‐Gervais, J., Maghmoul, Y., Tastet, O., & Mongrain, V. (2024) · Figshare · doi:10.6084/m9.figshare.26587146
Roig, M. N. B., Leduc, T., Dufort‐Gervais, J., Maghmoul, Y., Tastet, O., & Mongrain, V. (2024) · Figshare · doi:10.6084/m9.figshare.26587143
Roig, M. N. B., Leduc, T., Dufort‐Gervais, J., Maghmoul, Y., Tastet, O., & Mongrain, V. (2024) · Figshare · doi:10.6084/m9.figshare.26587140
Roig, M. N. B., Leduc, T., Dufort‐Gervais, J., Maghmoul, Y., Tastet, O., & Mongrain, V. (2024) · Figshare · doi:10.6084/m9.figshare.26587149
Spindola, A. (2019) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Pineau, L. (2023) · theses.fr (ABES) · doi:10.70675/39c790cfzdf57z416bzb9cez06eca43d9cda
Recharge, reboot, rewire: sleep optimizes information processing in neural circuits
Aton, S. J. (2026) · SLEEP · doi:10.1093/sleep/zsag146 · Cited by 1
Self-citationmTOR signalling, not clock gene rhythms, organises daily physiologyPreprint
Zeng, A., Mihut, A., Anandapadamanaban, M., Goity, A., Dantas, L. L. D. B., Chew, S. Y. P., Hayter, E. A., Andersson, L. C., Smith, T. S., Pasquini, G., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.28.747564
Metadata
- Authors
- Seibt, J., Dumoulin, M. C., Aton, S. J., Coleman, T., Watson, A., Naidoo, N., & Frank, M. G.
- Affiliations
- University of Bern (CH)
- University of Pennsylvania (US)
- Corresponding author
- Frank, Marcos G.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 22
- Issue
- 8
- Pages
- 676-682
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC3350782
- OpenAlex
- W2017764061
- Cited by
- 162
- References
- 39
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 19 · 2017: 16 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 16 · 2012: 12
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Heart, Lung, and Blood Institute (T32HL007953)
- National Eye Institute (F32EY006831, R01EY019022, R00EY021503, R01-EY 019002, F32EY017766, K99EY021503, T32EY007143)
- National Institute of General Medical Sciences (T32GM07517, T32GM007517)
- National Institute of Neurological Disorders and Stroke (F31NS067935)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep-dependent memory consolidation, protein synthesis, ocular dominance plasticity, visual cortex, mTOR inhibition, 4E-BP1, elongation factor 2, mRNA translation, Arc, brain-derived neurotrophic factor, cortical plasticity, cats
- MeSH terms
- Animals, Cats, Neuronal Plasticity, Phosphoproteins, Phosphorylation, Sleep, Transcription, Genetic, Protein Biosynthesis, Wakefulness, Brain-Derived Neurotrophic Factor, Dominance, Ocular, Mediator Complex, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
